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1.发明授权Methods for the identification of inhibitors of asparagine synthase as antibiotics 失效鉴定天门冬酰胺合酶抑制剂作为抗生素的方法公开(公告)号：US06852484B2
公开(公告)日：2005-02-08
申请号：US10012991
申请日：2001-12-10
申请人： Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarper , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan
发明人： Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarper , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan
IPC分类号： C12N9/00 , C12N9/10 , C12N9/16 , C12N9/88 , C12Q1/18 , C12Q1/00 , C07H21/04 , C12N1/20 , C12P21/06 , A31K31/18
CPC分类号： C12N9/93 , C12N9/1029 , C12N9/16 , C12N9/88 , C12Q1/18 , Y10S514/924
摘要： The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现天门冬酰胺合酶对于真菌致病性是必需的。 具体来说，真菌中天冬酰胺合酶基因表达的抑制没有导致成功感染或病变的迹象。 因此，天门冬酰胺合酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制天门冬酰胺合酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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2.发明授权Methods for the identification of inhibitors of threonine synthase as antibiotics 失效鉴定苏氨酸合酶抑制剂作为抗生素的方法公开(公告)号：US06806060B2
公开(公告)日：2004-10-19
申请号：US10011106
申请日：2001-12-07
申请人： Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo
发明人： Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo
IPC分类号： C12Q118
摘要： The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，苏氨酸合成酶对于真菌致病性是必需的。 具体地说，抑制真菌中的苏氨酸合成酶基因表达没有导致成功感染或病变的迹象。 因此，苏氨酸合成酶可以用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制苏氨酸合成酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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3.发明授权Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics 失效用于鉴定作为抗生素的3-异丙基苹果酸脱水酶抑制剂的方法公开(公告)号：US06733963B2
公开(公告)日：2004-05-11
申请号：US10010227
申请日：2001-12-06
申请人： Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer
发明人： Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer
IPC分类号： C12Q100
CPC分类号： C12N9/93 , C12N9/1029 , C12N9/16 , C12N9/88 , C12Q1/18 , Y10S514/924
摘要： The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现3-异丙基苹果酸脱水酶对于真菌致病性是必需的。 具体来说，真菌中3-异丙基苹果酸脱水酶基因表达的抑制没有导致成功感染或病变的迹象。 因此，3-异丙基马来酸脱水酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制3-异丙基苹果酸脱水酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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4.发明授权Methods for the identification of inhibitors of histidinol-phosphate as antibiotics 失效用于鉴定作为抗生素的组氨酸磷酸酯抑制剂的方法公开(公告)号：US06740498B2
公开(公告)日：2004-05-25
申请号：US10010084
申请日：2001-12-06
申请人： Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer
发明人： Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer
IPC分类号： C12Q142
CPC分类号： C12N9/93 , C12N9/1029 , C12N9/16 , C12N9/88 , C12Q1/18
摘要： The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，组氨醇磷酸酶是真菌致病性所必需的。 具体来说，在真菌中抑制组氨醇磷酸酶基因表达导致小的，非孢子形成的病变和致病性降低。 因此，组氨醇磷酸酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制组氨酸磷酸酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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5.发明授权Methods for the identification of inhibitors of &agr;-aminoadipate reductase as antibiotics 失效用于鉴定作为抗生素的α-氨基己二酸还原酶抑制剂的方法公开(公告)号：US06723529B2
公开(公告)日：2004-04-20
申请号：US10011146
申请日：2001-11-09
申请人： Matthew M. Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy K. Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey
发明人： Matthew M. Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy K. Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey
IPC分类号： C12Q104
CPC分类号： C12N9/0008 , C12N9/88 , C12Q1/18 , C12Q1/26 , C12Q1/527 , C12Y102/01031
摘要： The present inventors have discovered that &agr;-Aminoadipate Reductase is essential for fungal pathogenicity. Specifically, the inhibition of &agr;-Aminoadipate Reductase gene expression in fungi results in no signs of successful infection or lesions. Thus, &agr;-Aminoadipate Reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit &agr;-Aminoadipate Reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现α-氨基己二酸还原酶对于真菌致病性是必需的。 具体来说，在真菌中抑制α-氨基己二酸还原酶基因表达没有导致成功感染或病变的迹象。 因此，α-氨基己酸还原酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制α-氨基己二酸还原酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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6.发明授权Methods for the identification of inhibitors of homocitrate synthase as antibiotics 失效用于鉴定高柠檬酸合酶抑制剂作为抗生素的方法公开(公告)号：US06632631B1
公开(公告)日：2003-10-14
申请号：US10011200
申请日：2001-11-09
申请人： Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy K. Mahanty , Huaqin Pan , Amy Skalchunes , Rex W. Tarpey
发明人： Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy K. Mahanty , Huaqin Pan , Amy Skalchunes , Rex W. Tarpey
IPC分类号： C12Q118
CPC分类号： C12N9/0008 , C12N9/88 , C12Q1/18 , C12Q1/26 , C12Q1/527 , C12Y102/01031
摘要： The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，高柠檬酸合酶对于真菌致病性是必需的。 具体来说，抑制真菌中的高柠檬酸合酶基因表达没有导致成功感染或病变的迹象。 因此，高柠檬酸合酶可以用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制高柠檬酸合酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂
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