公开(公告)号：US20210403879A1

公开(公告)日：2021-12-30

申请号：US16768550

申请日：2018-11-30

申请人： TAKEDA VACCINES, INC.

发明人： Jill A LIVENGOOD ,  Holli GIEBLER ,  Hansi DEAN ,  Tatsuki SATOU ,  Raman RAO ,  Jackie MARKS ,  Mark LYONS ,  Asae SHINTANI ,  James GIFFORD ,  Nao OGASAWARA ,  Masafumi MISAKI ,  Satoshi ADACHI

IPC分类号： C12N7/00 ,  A61K39/12 ,  A61P31/14 ,  C12Q1/22

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.

公开(公告)号：US20240325518A1

公开(公告)日：2024-10-03

申请号：US18639558

申请日：2024-04-18

申请人： Takeda Vaccines, Inc.

发明人： Jill A. LIVENGOOD ,  Holli GIEBLER ,  Hansi DEAN ,  Tatsuki SATOU ,  Raman RAO ,  Jackie MARKS ,  Mark LYONS ,  Asae SHINTANI ,  James GIFFORD ,  Sushma Kommareddy

IPC分类号： A61K39/12 ,  A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  C12N2770/24034 ,  C12N2770/24071 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  C12N2770/24164

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

公开(公告)号：US20240285747A1

公开(公告)日：2024-08-29

申请号：US18242025

申请日：2023-09-05

申请人： Takeda Vaccines, Inc.

发明人： Jill A. LIVENGOOD ,  HANSI DEAN ,  Htay Htay HAN ,  Raman RAO ,  Jackie MARKS ,  Gary DUBIN ,  Laurence DE MOERLOOZE ,  Hetal PATEL ,  Asae SHINTANI ,  Holli GIEBLER ,  James GIFFORD ,  Mark LYONS ,  Sushma KOMMAREDDY ,  Tatsuki SATOU

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/22 ,  G01N30/74

CPC分类号： A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  C12Q1/22 ,  A61K2039/5252 ,  A61K2039/545 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  G01N30/74

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.

公开(公告)号：US20230398199A9

公开(公告)日：2023-12-14

申请号：US16768499

申请日：2018-11-30

申请人： TAKEDA VACCINES, INC.

发明人： Jill A. LIVENGOOD ,  Hansi DEAN ,  Htay Htay HAN ,  Raman RAO ,  Jackie MARKS ,  Gary DUBIN ,  Laurence DE MOERLOOZE ,  Hetal PATEL ,  Asae SHINTANI ,  Holli GIEBLER ,  James GIFFORD ,  Mark LYONS ,  Sushma KOMMAREDDY ,  Tatsuki SATOU

IPC分类号： A61K39/12 ,  A61P31/14

CPC分类号： A61K39/12 ,  A61P31/14 ,  A61K2039/545

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof

公开(公告)号：US20230204567A1

公开(公告)日：2023-06-29

申请号：US17999131

申请日：2021-03-19

申请人： Takeda Vaccines, Inc.

发明人： Jill LIVENGOOD ,  Michael JOHNSON ,  James GIFFORD ,  Tawnya NEAD ,  Mark LYONS ,  Jackie MARKS

IPC分类号： G01N33/542 ,  G01N33/533 ,  G01N33/569 ,  G01N33/68

CPC分类号： G01N33/542 ,  G01N33/533 ,  G01N33/56983 ,  G01N33/6878

摘要： The present disclosure relates to a method for determining the potency of an antigen sample such as a vaccine antigen sample. The present disclosure is also related to a method for monitoring the potency of a vaccine antigen during the production process including purifying, inactivating and formulating the vaccine antigen and to a method for producing a virus vaccine. Further, the present disclosure relates to vaccines obtainable by the methods disclosed. In certain embodiments of the present invention the antigen sample is a zika virus antigen sample.