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1.发明公开公开(公告)号：US20240325518A1
公开(公告)日：2024-10-03
申请号：US18639558
申请日：2024-04-18
发明人： Jill A. LIVENGOOD , Holli GIEBLER , Hansi DEAN , Tatsuki SATOU , Raman RAO , Jackie MARKS , Mark LYONS , Asae SHINTANI , James GIFFORD , Sushma Kommareddy
CPC分类号： A61K39/12 , A61K9/0019 , A61K39/39 , A61P31/14 , C12N7/00 , A61K2039/5252 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , C12N2770/24034 , C12N2770/24071 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , C12N2770/24164
摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.
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公开(公告)号：US20210403879A1
公开(公告)日：2021-12-30
申请号：US16768550
申请日：2018-11-30
发明人： Jill A LIVENGOOD , Holli GIEBLER , Hansi DEAN , Tatsuki SATOU , Raman RAO , Jackie MARKS , Mark LYONS , Asae SHINTANI , James GIFFORD , Nao OGASAWARA , Masafumi MISAKI , Satoshi ADACHI
摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.
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公开(公告)号：US20210177959A1
公开(公告)日：2021-06-17
申请号：US16761340
申请日：2018-11-05
发明人： Jill A. LIVENGOOD , Holli GIEBLER , Hansi DEAN , Tatsuki SATOU , Raman RAO , Jackie MARKS , Mark LYONS , Asae SHINTANI , Jamie GIFFORD
摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.
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公开(公告)号：US20240285747A1
公开(公告)日：2024-08-29
申请号：US18242025
申请日：2023-09-05
发明人： Jill A. LIVENGOOD , HANSI DEAN , Htay Htay HAN , Raman RAO , Jackie MARKS , Gary DUBIN , Laurence DE MOERLOOZE , Hetal PATEL , Asae SHINTANI , Holli GIEBLER , James GIFFORD , Mark LYONS , Sushma KOMMAREDDY , Tatsuki SATOU
CPC分类号： A61K39/12 , A61P31/14 , C12N7/00 , C12Q1/22 , A61K2039/5252 , A61K2039/545 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , G01N30/74
摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.
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公开(公告)号：US20230398199A9
公开(公告)日：2023-12-14
申请号：US16768499
申请日：2018-11-30
发明人： Jill A. LIVENGOOD , Hansi DEAN , Htay Htay HAN , Raman RAO , Jackie MARKS , Gary DUBIN , Laurence DE MOERLOOZE , Hetal PATEL , Asae SHINTANI , Holli GIEBLER , James GIFFORD , Mark LYONS , Sushma KOMMAREDDY , Tatsuki SATOU
CPC分类号： A61K39/12 , A61P31/14 , A61K2039/545
摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof
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公开(公告)号：US20230204567A1
公开(公告)日：2023-06-29
申请号：US17999131
申请日：2021-03-19
发明人： Jill LIVENGOOD , Michael JOHNSON , James GIFFORD , Tawnya NEAD , Mark LYONS , Jackie MARKS
IPC分类号： G01N33/542 , G01N33/533 , G01N33/569 , G01N33/68
CPC分类号： G01N33/542 , G01N33/533 , G01N33/56983 , G01N33/6878
摘要： The present disclosure relates to a method for determining the potency of an antigen sample such as a vaccine antigen sample. The present disclosure is also related to a method for monitoring the potency of a vaccine antigen during the production process including purifying, inactivating and formulating the vaccine antigen and to a method for producing a virus vaccine. Further, the present disclosure relates to vaccines obtainable by the methods disclosed. In certain embodiments of the present invention the antigen sample is a zika virus antigen sample.
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