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1.发明申请COMPOSITIONS AND METHODS FOR TREATING NEUROGENIC DISORDERS OF THE PELVIC FLOOR 审中-公开用于治疗皮肤病房神经病变的组合物和方法公开(公告)号：US20160038761A1
公开(公告)日：2016-02-11
申请号：US14921929
申请日：2015-10-23
CPC分类号： A61N5/062 , A61K38/177 , A61K48/005 , A61K49/0008 , A61N2005/0663 , C12N2750/14141
摘要： Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.
摘要翻译： 本文提供了通过使用稳定表达的光反应性视蛋白来治疗膀胱功能障碍的方法，所述膀胱功能障碍包括逼尿肌反射亢进和逼尿肌外括约肌乏力，大便失禁和/或个体中的性功能障碍，所述稳定表达的光反应性视蛋白能够选择性地超极化或去极化 神经细胞支配负责膀胱生理功能的肌肉，外泌尿括约肌，外肛门括约肌以及男性和女性生殖器。
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2.发明申请Compositions and Methods for Treating Neurogenic Disorders of the Pelvic Floor 审中-公开用于治疗盆底神经源性疾病的组合物和方法公开(公告)号：US20140024701A1
公开(公告)日：2014-01-23
申请号：US13772732
申请日：2013-02-21
IPC分类号： A61K38/17
CPC分类号： A61N5/062 , A61K38/177 , A61K48/005 , A61K49/0008 , A61N2005/0663 , C12N2750/14141
摘要： Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.
摘要翻译： 本文提供了通过使用稳定表达的光反应性视蛋白来治疗膀胱功能障碍的方法，所述膀胱功能障碍包括逼尿肌反射亢进和逼尿肌外括约肌乏力，大便失禁和/或个体中的性功能障碍，所述稳定表达的光反应性视蛋白能够选择性地超极化或去极化 神经细胞支配负责膀胱生理功能的肌肉，外泌尿括约肌，外肛门括约肌以及男性和女性生殖器。
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公开(公告)号：US11103723B2
公开(公告)日：2021-08-31
申请号：US14921929
申请日：2015-10-23
摘要： Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.
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公开(公告)号：US10307609B2
公开(公告)日：2019-06-04
申请号：US14911405
申请日：2014-08-13
发明人： Shrivats Mohan Iyer , Scott L. Delp , Kathryn L. Montgomery , Karl A. Deisseroth , Christopher Towne
摘要： The present disclosure provides compositions and methods for controlling pain. The present disclosure provides methods for identifying agents that control pain.
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公开(公告)号：US20160199663A1
公开(公告)日：2016-07-14
申请号：US14911405
申请日：2014-08-13
发明人： Shrivats Mohan Iyer , Scott L. Delp , Kathryn L. Montgomery , Karl A. Deisseroth , Christopher Towne
CPC分类号： A61N5/062 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/07 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K38/16 , A61K41/00 , A61K48/0058 , A61K48/0075 , A61N5/0622 , C12N15/8509 , C12N2015/8527 , C12N2750/14141
摘要： The present disclosure provides compositions and methods for controlling pain. The present disclosure provides methods for identifying agents that control pain.
摘要翻译： 本公开提供了用于控制疼痛的组合物和方法。 本公开提供了用于鉴定控制疼痛的药剂的方法。
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6.发明申请MATERIALS AND APPROACHES FOR OPTICAL STIMULATION OF THE PERIPHERAL NERVOUS SYSTEM 审中-公开外周神经系统光学刺激的材料与方法公开(公告)号：US20170072219A1
公开(公告)日：2017-03-16
申请号：US15351067
申请日：2016-11-14
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0601 , A61N5/0613 , A61N2005/0626 , A61N2005/0652
摘要： A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.
摘要翻译： 实施多种方法，装置，系统和布置以刺激周围神经系统。 根据本发明的一个实施例，实现了一种方法，其中光响应通道或泵被设计在包括不同物理体积的电动机单元的一组电动机单元中。 光学刺激还以光强度提供给光响应通道或泵，该光强度是要招募的电动机单元的尺寸的函数。 在某些实施方式中，光学刺激的强度增加，以便招募越来越大的电机单元。
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公开(公告)号：US10583309B2
公开(公告)日：2020-03-10
申请号：US15351067
申请日：2016-11-14
IPC分类号： A61N5/06
摘要： A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.
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8.发明申请Materials and Approaches for Optical Stimulation of the Peripheral Nervous System 审中-公开光学刺激外周神经系统的材料和方法公开(公告)号：US20140324133A1
公开(公告)日：2014-10-30
申请号：US14265013
申请日：2014-04-29
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0601 , A61N5/0613 , A61N2005/0626 , A61N2005/0652
摘要： A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.
摘要翻译： 实施多种方法，装置，系统和布置以刺激周围神经系统。 根据本发明的一个实施例，实现了一种方法，其中光响应通道或泵被设计在包括不同物理体积的电动机单元的一组电动机单元中。 光学刺激还以光强度提供给光响应通道或泵，该光强度是要招募的电动机单元的尺寸的函数。 在某些实施方式中，光学刺激的强度增加，以便招募越来越大的电机单元。
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公开(公告)号：US20190083573A1
公开(公告)日：2019-03-21
申请号：US16071043
申请日：2017-01-25
发明人： Shrivats Mohan Iyer , Scott L. Delp
IPC分类号： A61K38/17 , A61K48/00 , A61K31/5513 , A61P29/00
摘要： The present disclosure provides a method for modulating pain in a subject comprising activating an exogenous receptor expressed in a target neuron with an effective amount of an agent that specifically activates the exogenous receptor. The present disclosure provides a method for modulating the activity of a neuron comprising activating an exogenous receptor expressed in the neuron by contacting the neuron with an agent that specifically activates the exogenous receptor. The present disclosure provides a method of screening to identify compounds that modulate pain.
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公开(公告)号：US09308392B2
公开(公告)日：2016-04-12
申请号：US13849913
申请日：2013-03-25
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0601 , A61N5/0613 , A61N2005/0626 , A61N2005/0652
摘要： A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.
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