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公开(公告)号：US20240084332A1
公开(公告)日：2024-03-14
申请号：US18271684
申请日：2022-01-25
发明人： Feng Zhang , Han Altae-Tran , Soumya Kannan , Suchita Nety
CPC分类号： C12N15/907 , C12N9/22 , C12N15/11 , C12N15/70 , C12N15/74 , C12Y301/21 , C12N2310/20 , C12N2310/531 , C12N2800/101 , C12N2800/107 , C12N2800/80
摘要： Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.
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公开(公告)号：US20220364071A1
公开(公告)日：2022-11-17
申请号：US17264340
申请日：2019-07-31
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
IPC分类号： C12N9/78 , C12N9/22 , C12N15/11 , C12Q1/6823 , C12Q1/6851
摘要： The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides mutated Cas13 proteins and their use in modifying target sequences as well as mutated Cas13 nucleic acid sequences and vectors encoding mutated Cas13 proteins and vector systems or CRISPR-Cas13 systems.
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3.发明申请公开(公告)号：US20200248169A1
公开(公告)日：2020-08-06
申请号：US16623799
申请日：2018-06-26
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
摘要： The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one cytidine deaminase protein or catalytic domain thereof.
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公开(公告)号：US20240026382A1
公开(公告)日：2024-01-25
申请号：US18470189
申请日：2023-09-19
发明人： Feng Zhang , Soumya Kannan , Han Altae-Tran
CPC分类号： C12N15/90 , C12N9/22 , C12N15/102 , C12N9/78 , C12Y305/04005 , C12Y305/04004 , C12Y207/07049
摘要： Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.
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公开(公告)号：US20230392131A1
公开(公告)日：2023-12-07
申请号：US18032868
申请日：2021-10-22
CPC分类号： C12N9/22 , C12N15/102 , C12N15/63 , C12N2310/20
摘要： Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.
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公开(公告)号：US20230087228A1
公开(公告)日：2023-03-23
申请号：US17801815
申请日：2021-02-24
发明人： Feng Zhang , Han Altae-Tran , Soumya Kannan
摘要： The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides novel class 1, Type IV and novel class I, Type I Cas proteins and their use in modifying target sequences.
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公开(公告)号：US20230025039A1
公开(公告)日：2023-01-26
申请号：US17761292
申请日：2020-09-18
发明人： Feng Zhang , Han Altae-Tran , Soumya Kannan
摘要： The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides Cas proteins and their use in modifying target sequences.
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公开(公告)号：US11685916B2
公开(公告)日：2023-06-27
申请号：US15930478
申请日：2020-05-13
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
CPC分类号： C12N15/102 , C12N9/22 , A61K38/00 , C07K2319/71 , C12Y305/04004 , C12Y305/04005
摘要： The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
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公开(公告)号：US11618896B2
公开(公告)日：2023-04-04
申请号：US16649170
申请日：2018-09-21
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
摘要： The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
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公开(公告)号：US20220403357A1
公开(公告)日：2022-12-22
申请号：US17776269
申请日：2020-11-12
发明人： Feng Zhang , Soumya Kannan , Han Altae-Tran
摘要： The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides small Cas proteins and their use in modifying target sequences. In one aspect, the present disclosure provides a non-naturally occurring or engineered system comprising: a Cas protein that comprises a RuvC domain and a HNH domain, and is less than 850 amino acids in size; and a guide sequence capable of forming a complex with the Cas protein and directing the complex to bind to a target sequence.
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