公开(公告)号：US08932339B2

公开(公告)日：2015-01-13

申请号：US14065761

申请日：2013-10-29

申请人： The Johns Hopkins University

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/12 ,  A61M16/01 ,  A61M16/10 ,  A61F7/00 ,  A61M13/00 ,  A61M19/00 ,  A61M31/00 ,  A61M25/00 ,  A61M25/10 ,  A61M25/04

CPC分类号： A61F7/0085 ,  A61F7/12 ,  A61F2007/0063 ,  A61F2007/0064 ,  A61F2007/0065 ,  A61F2007/0068 ,  A61F2007/0069 ,  A61M13/003 ,  A61M16/01 ,  A61M16/1075 ,  A61M19/00 ,  A61M25/0029 ,  A61M25/003 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/04 ,  A61M31/00 ,  A61M2025/0002 ,  A61M2025/0073 ,  A61M2025/1047 ,  A61M2205/3368 ,  A61M2205/3606

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling. The method and device provide for cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation and cooling of the anatomical feature and/or systemic cooling, as intended. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest.

摘要翻译： 本发明提供了一种用于非侵入性解剖和系统冷却的方法和装置。 该方法和装置通过将不包括冷却剂的干燥流体输送到含粘液的空间或表面中来提供各种含有体液的空间或表面（例如含粘液的空间或表面）的冷却。 这样的粘液暴露于干燥的流体导致解剖特征和/或系统冷却的蒸发和冷却，如预期的那样。 以这种方式，可以实现治疗性低温，以在缺血性侮辱之后提供各种器官的神经保护，如心脏骤停后的大脑。

公开(公告)号：US20130204331A1

公开(公告)日：2013-08-08

申请号：US13751617

申请日：2013-01-28

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61F2007/126

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The present invention provides for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of mucus to the dry fluid yields evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. Therefore, therapeutic hypothermia may be achieved for neuroprotection of various organs after ischemic insult, like the brain after cardiac arrest. Similarly, excess fluid removal is achievable for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

摘要翻译： 本发明提供了用于非侵入式解剖和系统冷却，流体去除和/或能量去除的方法和装置。 本发明通过将不包括冷却剂的干燥流体输送到含粘液的空间或表面中或其上，提供流体的除去和各种含有体液的空间或表面（例如含粘液的空间或表面）的冷却。 将粘液暴露于干燥的液体会导致体液蒸发，去除能量，冷却解剖学特征以及全身冷却。 因此，缺血性呕吐后的各种器官的神经保护可能达到治疗低温，如心脏骤停后的大脑。 类似地，过量的液体去除可以用于治疗心源性休克或引起显着的液体积聚的其他病症，特别是在肾功能受损的情况下。 此外，本发明可用于减少发热，以及除热，能量和/或水是有益的其它条件。

公开(公告)号：US20230181353A1

公开(公告)日：2023-06-15

申请号：US17965606

申请日：2022-10-13

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Harikrishna Tandri ,  Menekhem Muz Zviman

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61F2007/126

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

公开(公告)号：US11523937B2

公开(公告)日：2022-12-13

申请号：US16903162

申请日：2020-06-16

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/00 ,  A61F7/12

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

公开(公告)号：US20210128346A1

公开(公告)日：2021-05-06

申请号：US16903162

申请日：2020-06-16

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/00

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

公开(公告)号：US20140053834A1

公开(公告)日：2014-02-27

申请号：US14065761

申请日：2013-10-29

申请人： The Johns Hopkins University

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/00 ,  A61M16/01 ,  A61M13/00

CPC分类号： A61F7/0085 ,  A61F7/12 ,  A61F2007/0063 ,  A61F2007/0064 ,  A61F2007/0065 ,  A61F2007/0068 ,  A61F2007/0069 ,  A61M13/003 ,  A61M16/01 ,  A61M16/1075 ,  A61M19/00 ,  A61M25/0029 ,  A61M25/003 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/04 ,  A61M31/00 ,  A61M2025/0002 ,  A61M2025/0073 ,  A61M2025/1047 ,  A61M2205/3368 ,  A61M2205/3606

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling. The method and device provide for cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation and cooling of the anatomical feature and/or systemic cooling, as intended. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest.

摘要翻译： 本发明提供了一种用于非侵入性解剖和系统冷却的方法和装置。 该方法和装置通过将不包括冷却剂的干燥流体输送到含粘液的空间或表面中来提供各种含有体液的空间或表面（例如含粘液的空间或表面）的冷却。 这样的粘液暴露于干燥的流体导致解剖特征和/或系统冷却的蒸发和冷却，如预期的那样。 以这种方式，可以实现治疗性低温，以在缺血性侮辱之后提供各种器官的神经保护，如心脏骤停后的大脑。

公开(公告)号：US11957617B2

公开(公告)日：2024-04-16

申请号：US17965606

申请日：2022-10-13

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Harikrishna Tandri ,  Menekhem Muz Zviman

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/0085 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61F2007/126

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

公开(公告)号：US20180153737A1

公开(公告)日：2018-06-07

申请号：US15652376

申请日：2017-07-18

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/0085 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61F2007/126

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

公开(公告)号：US09744071B2

公开(公告)日：2017-08-29

申请号：US13751617

申请日：2013-01-28

申请人： The Johns Hopkins University

发明人： Tandri Harikrishna ,  Menekhem Muz Zviman

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/0085 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61F2007/126

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The present invention provides for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of mucus to the dry fluid yields evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. Therefore, therapeutic hypothermia may be achieved for neuroprotection of various organs after ischemic insult, like the brain after cardiac arrest. Similarly, excess fluid removal is achievable for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.