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公开(公告)号：US11129983B2
公开(公告)日：2021-09-28
申请号：US16043414
申请日：2018-07-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US10391310B2
公开(公告)日：2019-08-27
申请号：US15470542
申请日：2017-03-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Wentai Liu , James C. Y. Dunn , Benjamin M. Wu , Yi-Kai Lo , Chih-Wei Chang , Justin P. Wagner
Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.
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公开(公告)号：US20220016420A1
公开(公告)日：2022-01-20
申请号：US17459483
申请日：2021-08-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US20190038899A1
公开(公告)日：2019-02-07
申请号：US16043414
申请日：2018-07-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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5.发明申请公开(公告)号：US20190022371A1
公开(公告)日：2019-01-24
申请号：US15750499
申请日：2016-08-05
Applicant: The Regents of the University of California
Inventor： Chih-Wei Chang , Victor Reggie Edgerton , Wentai Liu , Yuri Gerasimenko , Parag Gad , Yi-Kai Lo
Abstract: In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where the needles are solid, or where the needles are hollow and have a closed tip, where the needles have an average tip diameter less than about 10 μm and an average length greater than about 20-50 μm wherein the electrically conductive needles are electrically coupled to one or more electrical leads.
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Patent Agency Ranking
公开(公告)号：US20250025689A1
公开(公告)日：2025-01-23
申请号：US18668799
申请日：2024-05-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US11986653B2
公开(公告)日：2024-05-21
申请号：US17459483
申请日：2021-08-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
CPC classification number: A61N1/36003 , A61N1/0551 , A61N1/3787 , A61N1/08
Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US10583285B2
公开(公告)日：2020-03-10
申请号：US15506699
申请日：2015-08-27
Applicant: The Regents of the University of California
Inventor： Wentai Liu , Chih-Wei Chang
Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
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9.发明申请公开(公告)号：US20180221651A1
公开(公告)日：2018-08-09
申请号：US15749479
申请日：2016-08-05
Applicant: The Regents of the University of California
Inventor： Chih-Wei Chang , Wentai Liu , Yi-Kai Lo
IPC: A61N1/05 , B23K26/362 , B23K26/40 , B23K26/342 , A61N1/04 , A61N1/36 , B33Y80/00 , B33Y10/00 , B22F3/00
CPC classification number: A61N1/0502 , A61N1/0456 , A61N1/0476 , A61N1/36017 , B21D22/00 , B22F3/008 , B23K26/342 , B23K26/361 , B23K26/362 , B23K26/38 , B23K26/40 , B23K2101/20 , B23K2101/38 , B23K2103/05 , B23K2103/08 , B23K2103/42 , B23K2103/50 , B33Y10/00 , B33Y70/00 , B33Y80/00
Abstract: In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where the needles are solid, or where the needles are hollow and have a closed tip, where the needles have an average tip diameter less than about 10 μm and an average length greater than about 20-50 μm wherein the electrically conductive needles are electrically coupled to one or more electrical leads.
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公开(公告)号：US20170266440A1
公开(公告)日：2017-09-21
申请号：US15470542
申请日：2017-03-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Wentai Liu , James C.Y. Dunn , Benjamin M. Wu , Yi-Kai Lo , Chih-Wei Chang , Justin P. Wagner
CPC classification number: A61N1/36007 , A61B5/4233 , A61B5/4238 , A61B5/4255 , A61F5/0026 , A61N1/0509 , A61N1/0517 , A61N1/08
Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.
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