公开(公告)号：US20240245733A1

公开(公告)日：2024-07-25

申请号：US18435722

申请日：2024-02-07

申请人： The Regents of the University of California ,  U.S. Govenment Represented by the Department of Veterans Affairs

发明人： Casey Ward ,  Qizhi TANG ,  Peter STOCK ,  Gaetano FALEO ,  Gopika NAIR ,  Matthias HEBROK ,  Wenhan CHANG ,  Thuy VO ,  Jeffrey A. BLUESTONE ,  Elenora DE KLERK

IPC分类号： A61K35/55 ,  A61K9/00 ,  A61K35/39 ,  A61P3/10 ,  C12N5/071

CPC分类号： A61K35/55 ,  A61K9/0019 ,  A61K9/0024 ,  A61K35/39 ,  A61P3/10 ,  C12N5/0617 ,  C12N5/0676 ,  A61K2300/00 ,  C12N2506/02 ,  C12N2506/078

摘要： Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.

公开(公告)号：US20180036345A1

公开(公告)日：2018-02-08

申请号：US15721439

申请日：2017-09-29

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Qizhi TANG ,  Jeffrey A. BLUESTONE

IPC分类号： A61K35/17 ,  A61K31/573 ,  C12N5/0781 ,  A61K31/5377 ,  A61K31/436 ,  C12N5/0783 ,  A61K39/00

CPC分类号： A61K35/17 ,  A61K31/436 ,  A61K31/5377 ,  A61K31/573 ,  A61K39/001 ,  A61K2300/00 ,  C12N5/0635 ,  C12N5/0637 ,  C12N2501/04 ,  C12N2501/2304 ,  C12N2501/515 ,  C12N2502/1107 ,  C12N2502/30

摘要： The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.

公开(公告)号：US20240301403A1

公开(公告)日：2024-09-12

申请号：US18263366

申请日：2022-01-28

申请人： The Regents of the University of California

发明人： Daniel B. GOODMAN ,  Camillia S. AZIMI ,  Kole T. ROYBAL ,  Jeffrey A. BLUESTONE ,  Alexander MARSON

IPC分类号： C12N15/10 ,  C12N15/86

CPC分类号： C12N15/1093 ,  C12N15/86 ,  C12N2750/14143

摘要： This disclosure generally relates to high-throughput and modular methods and compositions for barcode-trackable cellular receptor design, manufacture, and measurement.

公开(公告)号：US20230312673A1

公开(公告)日：2023-10-05

申请号：US18043716

申请日：2021-09-01

申请人： The Regents of the University of California

发明人： Kole T. ROYBAL ,  Daniel B. GOODMAN ,  Camillia AZIMI ,  Alexander MARSON ,  Jeffrey A. BLUESTONE

IPC分类号： C07K14/725 ,  C07K14/705

CPC分类号： C07K14/7051 ,  C07K14/70521 ,  C07K14/70575 ,  C07K2317/622 ,  C07K2319/03

摘要： This disclosure relates to chimeric receptors (CRs) and their signaling components for the regulation of an immune response. Also provided are nucleic acids encoding the disclosed CRs, recombinant immune cells expressing the same, and pharmaceutical compositions containing the disclosed nucleic acids and/or recombinant cells. Further provided are methods useful for modulating an activity of an immune cell, methods for modulating an immune response in an individual, as well as methods for treating a health condition in an individual in needed thereof

公开(公告)号：US20210032308A1

公开(公告)日：2021-02-04

申请号：US17035327

申请日：2020-09-28

申请人： PFIZER INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Natasha Kay CRELLIN ,  Lauren Kate ELY ,  Jason Robles REYES ,  Chia Chi HO ,  Jeffrey A. BLUESTONE ,  Eleonora TROTTA ,  Qizhi TANG

IPC分类号： C07K14/705 ,  G01N33/68

摘要： The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules. The invention includes uses, and associated methods of using the LFA3 polypeptide molecules.

公开(公告)号：US20230381228A1

公开(公告)日：2023-11-30

申请号：US18034037

申请日：2021-10-29

申请人： The Regents of the University of California ,  Université Libre de Bruxelles ,  Vrije Universiteit Brussel

发明人： Qizhi TANG ,  Jeffrey A. BLUESTONE ,  Emilie RONIN ,  Decio L. EIZIRIK ,  Nick M. DEVOOGDT

IPC分类号： A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P3/10 ,  C07K16/28 ,  C07K14/705 ,  A61K39/00

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C12N5/0636 ,  A61P3/10 ,  C07K16/2812 ,  C07K14/70521 ,  A61K39/4631

摘要： The present disclosure relates generally to regulatory T cells (Tregs) engineered to express a dipeptidyl aminopeptidase-like protein 6 (DPP6)-reactive chimeric antigen receptor (CAR). The engineered Tregs are suitable for use in immunotherapy regimens for autoimmune, inflammatory and degenerative diseases. In particular, the anti-DPP6 CAR expressing Tregs are suitable for treating or preventing autoimmune diseases of the pancreas or central nervous system.

公开(公告)号：US20230340068A1

公开(公告)日：2023-10-26

申请号：US18044772

申请日：2021-09-09

申请人： The Regents of the University of California

发明人： Yannick MULLER ,  Jeffrey A. BLUESTONE ,  Qizhi TANG

IPC分类号： C07K14/705 ,  C07K14/725 ,  A61K45/06 ,  A61K38/17 ,  A61K39/00 ,  C07K16/28

CPC分类号： C07K14/70521 ,  C07K14/70517 ,  C07K14/7051 ,  A61K45/06 ,  A61K38/1774 ,  A61K39/464412 ,  A61K39/4611 ,  C07K16/2803 ,  C07K2319/33 ,  C07K2319/03 ,  C07K2319/02 ,  C07K2317/53 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2317/76 ,  A61K2039/545 ,  A61K39/4631 ,  A61K2239/21 ,  A61K2239/22 ,  A61K2239/38 ,  A61K2239/17 ,  A61K2239/13

摘要： The present disclosure relates generally to the field of immuno-therapeutics, and particularly relates to novel chimeric polypeptides, e.g., chimeric antigen receptors (CARs) that include a transmembrane domain from CD28 and a hinge domain. In some cases, the hinge domain is capable of promoting dimerization of the CARs. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of health conditions, such as proliferative diseases (e.g., cancer).

公开(公告)号：US20160311906A1

公开(公告)日：2016-10-27

申请号：US15081305

申请日：2016-03-25

申请人： The Regents of the University of California

发明人： Lewis L. LANIER ,  Koetsu OGASAWARA ,  Jeffrey A. BLUESTONE

IPC分类号： C07K16/28 ,  G01N33/50

CPC分类号： C07K16/2851 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/77 ,  G01N33/5047

摘要： The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

摘要翻译： 本发明涉及用于治疗和/或预防与病毒感染和实体器官移植排斥相关的炎症的方法和组合物。 特别地，本发明提供了通过调节NKG2D来损害自身反应性T细胞，NK细胞和/或NKT细胞的扩增和功能的治疗剂。

公开(公告)号：US20140120082A1

公开(公告)日：2014-05-01

申请号：US13797921

申请日：2013-03-12

申请人： The Regents of the University of California

发明人： Lewis L. LANIER ,  Koetsu OGASAWARA ,  Jeffrey A. BLUESTONE

IPC分类号： A61K39/395

CPC分类号： A61K39/39541 ,  A61K2039/505 ,  C07K16/2851 ,  C07K2316/96 ,  C07K2317/73 ,  C07K2317/76 ,  Y10S514/885

摘要： The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.

摘要翻译： 本发明涉及用于治疗和/或预防自身免疫和/或炎性疾病的方法和组合物。 特别地，本发明提供了通过调节NKG2D来损害自身反应性T细胞，NK细胞和/或NKT细胞的扩增和功能的治疗剂。