公开(公告)号：US20140348815A1

公开(公告)日：2014-11-27

申请号：US14288110

申请日：2014-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh-Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K38/47 ,  A61K47/30 ,  A61K38/38

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

Abstract translation: 提出了生物活性和化学货物在稳定的交联聚合物基质中的微胶囊化，其导致小的颗粒尺寸并且易于放大用于工业应用。 酸溶性多价离子盐，用挥发性碱中和的酸和在多价离子存在下交联的一种或多种单体的配方被雾化成液滴。 交联是在雾化时实现的，其中挥发性碱被汽化，导致制剂的pH降低，并且多价离子从与形成胶囊的单体交联的盐的时间释放。 在制剂中加入另外的聚合物或疏水性化合物可以控制颗粒的水合性质以控制包封的化合物的释放。 还可以控制操作参数以影响胶囊性质，例如粒度和粒度分布。

公开(公告)号：US20170333360A1

公开(公告)日：2017-11-23

申请号：US15615520

申请日：2017-06-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K38/38 ,  A61K47/30 ,  B01J13/04 ,  C08J3/24 ,  C08J3/12 ,  A61K38/47 ,  A61K9/16

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

公开(公告)号：US09700519B2

公开(公告)日：2017-07-11

申请号：US14288110

申请日：2014-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K31/734 ,  A61K47/30 ,  A61K9/16 ,  B01J13/04 ,  C08J3/12 ,  C08J3/24 ,  A61K38/38 ,  A61K38/47

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.