公开(公告)号：US10271744B2

公开(公告)日：2019-04-30

申请号：US15136268

申请日：2016-04-22

Applicant: The Regents of the University of California ,  Topera, Inc.

Inventor： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/042 ,  A61B5/04 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/046

Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

公开(公告)号：US10856760B2

公开(公告)日：2020-12-08

申请号：US15649494

申请日：2017-07-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  TOPERA, INC.

Inventor： Sanjiv M. Narayan ,  Ruchir Sehra

IPC: A61B5/04 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/042 ,  A61B5/0472 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/00 ,  A61B5/0255 ,  A61B5/0432 ,  A61B5/044

Abstract: A system for processing cardiac activation information associated with a complex rhythm disorder identifies a location of the heart rhythm disorder by determining activations within cardiac signals obtained at neighboring locations of the heart and arranging the activations to identify an activation trail. The activation trail may define a rotational pattern or radially emanating pattern corresponding to an approximate core of the heart rhythm disorder.

公开(公告)号：US20200061384A1

公开(公告)日：2020-02-27

申请号：US16562099

申请日：2019-09-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  TOPERA, INC.

Inventor： Sanjiv M. Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61N1/37 ,  A61N1/362 ,  A61N1/365 ,  A61N1/378 ,  A61B5/00 ,  A61B5/024 ,  A61B5/042

Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

公开(公告)号：US10398326B2

公开(公告)日：2019-09-03

申请号：US14473990

申请日：2014-08-29

Applicant: The Regents of the University of California ,  Topera, Inc.

Inventor： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/024 ,  A61B18/12 ,  A61N1/32 ,  A61N1/368 ,  A61B5/00 ,  A61B5/042 ,  A61B18/00

Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance with therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element. A plurality of indexes of progressive rotational activations or progressive focal activations over time is formed. One or more indexes are selected from the plurality of indexes that indicate consistency of the successive rotational activations or the progressive focal activations in relation to a portion of the region of the heart.

公开(公告)号：US09668666B2

公开(公告)日：2017-06-06

申请号：US14944096

申请日：2015-11-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Topera, Inc.

Inventor： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/04 ,  A61B5/0255 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/00

CPC classification number: A61B5/04012 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/0402 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B2562/046

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

公开(公告)号：US10434319B2

公开(公告)日：2019-10-08

申请号：US15585091

申请日：2017-05-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  TOPERA, INC.

Inventor： Sanjiv M. Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/042 ,  A61N1/37 ,  A61N1/362 ,  A61N1/365 ,  A61N1/378 ,  A61B18/00

Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

公开(公告)号：US10085655B2

公开(公告)日：2018-10-02

申请号：US14774120

申请日：2014-03-14

Applicant: The Regents of the University of California ,  Topera, Inc.

Inventor： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/0452 ,  A61B5/024 ,  A61B5/00 ,  A61B5/042 ,  A61B5/04 ,  A61B5/044

Abstract: A system and method are provided for identifying a driver of a source associated with a heart rhythm disorder. Data are accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and determine whether the first region controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.

公开(公告)号：US20170049402A1

公开(公告)日：2017-02-23

申请号：US15344230

申请日：2016-11-04

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Topera, Inc.

Inventor： Sanjiv M. Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/00 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/024 ,  A61B5/0245

CPC classification number: A61B5/04012 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/0402 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B2562/046

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association among the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

Abstract translation: 在用于重建心脏激活信息的系统和方法中，访问和处理分析心脏信号和参考心脏信号以确定分析心脏信号的第一变化点，其中分析心脏信号的导数相对于 衍生的参考心脏信号。 对信号进行处理，以确定分析心脏信号中相对于参考心脏信号的不同导数的分析心脏信号的不同导数的第二变化点。 在基于第一变化点与第二变化点之间的数学关联的点上的分析心脏信号中分配激活开始时间，以定义指示分析心脏信号中的搏动的心脏激活。

公开(公告)号：US20160278654A1

公开(公告)日：2016-09-29

申请号：US14944096

申请日：2015-11-17

Applicant: The Regents of the University of California ,  Topera, Inc.

Inventor： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/04 ,  A61B5/0255 ,  A61B5/00 ,  A61B5/0468 ,  A61B5/0472

CPC classification number: A61B5/04012 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/0402 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B2562/046

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

Abstract translation: 在用于重建心脏激活信息的系统和方法中，访问和处理分析心脏信号和参考心脏信号以确定分析心脏信号的第一变化点，其中分析心脏信号的导数相对于 衍生的参考心脏信号。 对信号进行处理，以确定分析心脏信号中相对于参考心脏信号的不同导数的分析心脏信号的不同导数的第二变化点。 在基于第一变化点和第二变化点的数学关联点的点处在分析心脏信号中分配激活开始时间，以定义指示分析心脏信号中的搏动的心脏激活。

公开(公告)号：US20160235311A1

公开(公告)日：2016-08-18

申请号：US15136268

申请日：2016-04-22

Applicant: The Regents of the University of California ,  Topera, Inc.

Inventor： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/0452

CPC classification number: A61B5/02405 ,  A61B5/0002 ,  A61B5/0006 ,  A61B5/02444 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/6852 ,  A61B2560/0475 ,  A61B2562/04

Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

Abstract translation: 在用于识别与心律紊乱相关的源的驾驶员的系统和方法中，从表示心脏中的生物活性的多个传感器访问数据。 鉴定出心脏的第一区域和第二区域，其包括心律失常的来源。 如果心脏的第一区域具有重复的离心激活并且控制心脏的第二区域至少预定数量的搏动，则将第一区域识别为控制心律紊乱的来源。