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公开(公告)号：US10271786B2
公开(公告)日：2019-04-30
申请号：US15204455
申请日：2016-07-07
Applicant: The Regents of the University of California , Topera, Inc.
Inventor： Sanjiv Narayan , Carey Robert Briggs
Abstract: Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.
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公开(公告)号：US10271744B2
公开(公告)日：2019-04-30
申请号：US15136268
申请日：2016-04-22
Applicant: The Regents of the University of California , Topera, Inc.
Inventor： Sanjiv Narayan , Carey Robert Briggs , Ruchir Sehra
Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.
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公开(公告)号：US20140371614A1
公开(公告)日：2014-12-18
申请号：US14473572
申请日：2014-08-29
Applicant: The Regents of the University of California , Topera, Inc.
Inventor： Sanjiv Narayan , Carey Robert Briggs
IPC: A61B5/0452
CPC classification number: A61B5/4836 , A61B5/02405 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/7203 , A61B5/7239 , A61B5/7278 , A61B2562/0209 , A61B2562/046 , G06F19/00 , G06F19/3418 , G16H10/60
Abstract: An example method of representing cardiac information associated with a heart rhythm disorder is disclosed. The method includes accessing a plurality of neighboring cardiac signals obtained from a patient. The method also includes eliminating far-field activations from the plurality of neighboring cardiac signals using one or more divergence criteria that define local activations in the plurality of neighboring cardiac signals, the divergence criteria being associated with divergence among the plurality of neighboring cardiac signals. The method further includes constructing a clinical representation of local activations in the plurality of neighboring cardiac signals.
Abstract translation: 公开了一种代表与心律失常相关的心脏信息的示例性方法。 该方法包括访问从患者获得的多个相邻心脏信号。 该方法还包括使用限定多个相邻心脏信号中的局部激活的一个或多个发散标准来消除来自多个相邻心脏信号的远场激活，该发散标准与多个相邻心脏信号之间的发散相关。 该方法还包括构建多个相邻心脏信号中局部激活的临床表示。
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公开(公告)号：US20140066787A1
公开(公告)日：2014-03-06
申请号：US14074619
申请日：2013-11-07
Applicant: Topera, Inc. , The Regents of the University of California
Inventor： Sanjiv Narayan , Carey Robert Briggs
IPC: A61B5/0205 , A61B5/0452
CPC classification number: A61B5/02405 , A61B5/0002 , A61B5/0205 , A61B5/0255 , A61B5/04011 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61B5/6852 , A61B5/7203 , A61B5/7217 , A61B5/7239 , A61B5/7246 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B5/743 , A61B18/02 , A61B18/12 , A61B18/18 , A61B2018/00577 , A61B2562/046
Abstract: An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient. The first cardiac signal and the second cardiac signal are processed to determine whether there is a point of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to a derivative of the second cardiac signal above a threshold. An activation onset time is assigned in the first cardiac signal at the point of change to define a cardiac activation if the point of change is in the first cardiac signal.
Abstract translation: 公开了一种处理心脏激活信息的示例系统和方法。 该方法包括访问从患者获得的第一心脏信号和第二心脏信号。 处理第一心脏信号和第二心脏信号以确定在第一心脏信号中是否存在相对于高于阈值的第二心脏信号的导数发散的第一心脏信号的导数的改变点。 如果变化点在第一心脏信号中，则在改变点的第一心脏信号中分配激活起始时间以定义心脏激活。
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公开(公告)号：US20200061384A1
公开(公告)日：2020-02-27
申请号：US16562099
申请日：2019-09-05
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TOPERA, INC.
Inventor： Sanjiv M. Narayan , Carey Robert Briggs , Ruchir Sehra
Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.
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Patent Agency Ranking
公开(公告)号：US10398326B2
公开(公告)日：2019-09-03
申请号：US14473990
申请日：2014-08-29
Applicant: The Regents of the University of California , Topera, Inc.
Inventor： Sanjiv Narayan , Carey Robert Briggs , Ruchir Sehra
Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance with therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element. A plurality of indexes of progressive rotational activations or progressive focal activations over time is formed. One or more indexes are selected from the plurality of indexes that indicate consistency of the successive rotational activations or the progressive focal activations in relation to a portion of the region of the heart.
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公开(公告)号：US10058262B2
公开(公告)日：2018-08-28
申请号：US15194357
申请日：2016-06-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Topera, Inc.
Inventor： Carey Robert Briggs , Sanjiv M. Narayan
IPC: A61B5/046 , A61B5/0468 , A61B5/00 , A61B5/044 , A61B5/042 , A61B5/04 , A61B5/0452 , A61B8/02 , A61B5/0464 , A61B5/024
CPC classification number: A61B5/0468 , A61B5/002 , A61B5/02405 , A61B5/04011 , A61B5/04012 , A61B5/042 , A61B5/0422 , A61B5/044 , A61B5/0452 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61B5/7246 , A61B5/7257 , A61B5/7425 , A61B5/743 , A61B8/02
Abstract: In a system and method of determining regularity associated with a rhythm disorder of a heart, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardiac signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.
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公开(公告)号：US20170245774A1
公开(公告)日：2017-08-31
申请号：US15593135
申请日：2017-05-11
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TOPERA, INC.
Inventor： Sanjiv M. Narayan , Carey Robert Briggs
CPC classification number: A61B5/04012 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/4029 , A61B5/4064 , A61B5/4839 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00839 , A61M5/00 , A61N1/0565
Abstract: A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.
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公开(公告)号：US09668666B2
公开(公告)日：2017-06-06
申请号：US14944096
申请日：2015-11-17
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Topera, Inc.
Inventor： Sanjiv Narayan , Carey Robert Briggs , Ruchir Sehra
IPC: A61B5/04 , A61B5/0255 , A61B5/0468 , A61B5/0472 , A61B5/00
CPC classification number: A61B5/04012 , A61B5/0205 , A61B5/024 , A61B5/02405 , A61B5/0245 , A61B5/0255 , A61B5/04011 , A61B5/0402 , A61B5/0422 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/0472 , A61B5/4836 , A61B5/6852 , A61B5/7203 , A61B5/7207 , A61B5/7217 , A61B5/7239 , A61B5/7246 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B2562/046
Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
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公开(公告)号：US20170007176A1
公开(公告)日：2017-01-12
申请号：US15204455
申请日：2016-07-07
Applicant: The Regents of the University of California , Topera, Inc.
Inventor： Sanjiv Narayan , Carey Robert Briggs
CPC classification number: A61B5/4836 , A61B5/02405 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/7203 , A61B5/7239 , A61B5/7278 , A61B2562/0209 , A61B2562/046 , G06F19/00 , G06F19/3418 , G16H10/60
Abstract: Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.
Abstract translation: 与心律紊乱相关的心脏信息的重建包括使用定义局部激活的一个或多个发散标准来访问多个相邻的心脏信号并消除来自相邻心脏信号的远场激活，其中发散标准与 多个相邻的心脏信号。 多个相邻心脏信号中的局部激活可用于构建心律失常的临床表现。
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