公开(公告)号：US20240136019A1

公开(公告)日：2024-04-25

申请号：US18547705

申请日：2022-02-24

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Andrew B. Ward ,  Aleksandar Antanasijevic ,  Charles Bowman ,  Christopher Cottrell ,  Gabriel Ozorowski ,  Robert Kirchdoerfer

IPC: G16B30/10 ,  G01N33/577

CPC classification number: G16B30/10 ,  G01N33/577

Abstract: Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.

公开(公告)号：US10960070B2

公开(公告)日：2021-03-30

申请号：US16344774

申请日：2017-10-25

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Scripps Research Institute ,  Trustees of Dartmouth College

Inventor： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC: A61K39/215 ,  C12N7/00 ,  A61P31/14 ,  C07K14/005

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20240233873A9

公开(公告)日：2024-07-11

申请号：US18547705

申请日：2022-02-24

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Andrew B. Ward ,  Aleksandar Antanasijevic ,  Charles Bowman ,  Christopher Cottrell ,  Gabriel Ozorowski ,  Robert Kirchdoerfer

IPC: G16B30/10 ,  G01N33/577

CPC classification number: G16B30/10 ,  G01N33/577

Abstract: Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.

公开(公告)号：US11964010B2

公开(公告)日：2024-04-23

申请号：US17194834

申请日：2021-03-08

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Scripps Research Institute ,  Trustees of Dartmouth College

Inventor： Barney Graham ,  Jason Mclellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC: A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20210275664A1

公开(公告)日：2021-09-09

申请号：US17194834

申请日：2021-03-08

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

Inventor： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC: A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20200061185A1

公开(公告)日：2020-02-27

申请号：US16344774

申请日：2017-10-25

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

Inventor： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC: A61K39/215 ,  C07K14/005 ,  A61P31/14 ,  C12N7/00

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.