公开(公告)号：US20210275833A1

公开(公告)日：2021-09-09

申请号：US17313838

申请日：2021-05-06

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  DOSEOPTICS, LLC

Inventor： Venkataramanan Krishnaswamy ,  Petr Bruza, JR. ,  Michael Jermyn ,  Brian W. Pogue ,  David Gladstone ,  Lesley A. Jarvis ,  Irwin Tendler

IPC: A61N5/10 ,  G01T1/20 ,  G01T1/22

Abstract: A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging.

公开(公告)号：US20210001153A1

公开(公告)日：2021-01-07

申请号：US16975301

申请日：2019-02-22

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Brian W. Pogue ,  Petr Bruza ,  David Gladstone ,  Lesley A. Jarvis ,  Irwin Tendler

IPC: A61N5/10 ,  G01T1/20 ,  G01T1/15 ,  G01T7/00

Abstract: A system for dosimetry includes a radiation source that provides a pulsed radiation beam to a treatment zone, and a thin sheet of scintillator disposed between the radiation source and skin of a subject in the treatment zone. A gated camera images the scintillator integrating light from the scintillator during multiple pulses of the radiation beam while excluding light received between pulses of the pulsed radiation beam; and an image capture and processing machine that receives images from the gated camera and performs additional corrections to provide a map of dose received by the subject.

公开(公告)号：US12036421B2

公开(公告)日：2024-07-16

申请号：US18563813

申请日：2022-05-25

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Petr Bruza ,  Brian Pogue ,  Ramish Ashraf ,  Rongxiao Zhang ,  David Gladstone ,  Megan Clark ,  Roman Vasyltsiv

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1071 ,  A61N2005/1059

Abstract: A system for delivering ultra-high dose rate irradiation to a target area of a patient, includes a pulsed charged-particle source along a beam axis; a collimator for shaping the beam of radiation; one or more cameras for imaging the target area of the patient; and a dosimetry controller for providing control signals to the charged-particle source one or more dosimeters positioned between an output of the charged-particle source and the collimator in beam fringes for measuring a radiation dosage provided by each pulse; and a beam scanning coil positioned between the collimator and the patient for directing the shaped beam. The dosimetry controller receives feedback from the one or more dosimeters and provides control signals to the particle source and the beam scanning coil that modulate final pulses in the series of pulses in real-time.

公开(公告)号：US11633627B2

公开(公告)日：2023-04-25

申请号：US17313838

申请日：2021-05-06

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  DOSEOPTICS, LLC

Inventor： Venkataramanan Krishnaswamy ,  Petr Bruza, Jr. ,  Michael Jermyn ,  Brian W. Pogue ,  David Gladstone ,  Lesley A. Jarvis ,  Irwin Tendler

IPC: A61N5/10 ,  G01T1/20 ,  G01T1/22

Abstract: A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging.