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1.发明授权公开(公告)号：US12029922B2
公开(公告)日：2024-07-09
申请号：US17627633
申请日：2020-07-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Rachael Hachadorian , Brian Pogue , Petr Bruza , Lesley Jarvis
CPC classification number: A61N5/1071 , A61N5/10 , A61N5/103 , A61N5/1039 , A61N5/1048 , A61N5/1049 , G01T1/22 , G01T1/2992 , A61N2005/1055 , A61N2005/1059 , A61N2005/1061 , A61N2005/1087 , A61N2005/1089
Abstract: A system for monitoring radiation treatment images Cherenkov emissions from tissue of a subject. A processor of the system determines densities of a surface layer of the subject from 3D images of the tissue to determine correction factors. The processor uses these factors to correct the Cherenkov images for attenuation of Cherenkov light by tissue, making them proportional to radiation dose. In embodiments, the system obtains reflectance images of the subject, determines second correction factors therefrom, and applies the second correction factors to the Cherenkov emissions images. In embodiments, the corrected images of Cherenkov emissions are compared to dose maps of a treatment plan. A method of correcting Cherenkov emissions images includes determining tissue characteristics from CT or MRI images in a surface volume where Cherenkov is expected, using; imaging Cherenkov emissions; and using the tissue characteristics to correct the images for variations in Cherenkov light propagation through the tissue.
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公开(公告)号：US20210001153A1
公开(公告)日：2021-01-07
申请号：US16975301
申请日：2019-02-22
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Brian W. Pogue , Petr Bruza , David Gladstone , Lesley A. Jarvis , Irwin Tendler
Abstract: A system for dosimetry includes a radiation source that provides a pulsed radiation beam to a treatment zone, and a thin sheet of scintillator disposed between the radiation source and skin of a subject in the treatment zone. A gated camera images the scintillator integrating light from the scintillator during multiple pulses of the radiation beam while excluding light received between pulses of the pulsed radiation beam; and an image capture and processing machine that receives images from the gated camera and performs additional corrections to provide a map of dose received by the subject.
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Patent Agency Ranking
公开(公告)号：US12196894B2
公开(公告)日：2025-01-14
申请号：US17796488
申请日：2021-01-29
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
Inventor： Petr Bruza , Brian Pogue , Venkataramanan Krishnaswamy
Abstract: A Cherenkov imaging system includes a high-speed radiation detector configured to provide a first timing signal synchronized with pulses of radiation to control operation of at least one pulse-gated, multiple-pulse-integrating, (PG-MPI) CMOS camera synchronized through the digital time signal to pulses of the radiation beam source, to image Cherenkov radiation; and a digital image-processing system. The high-speed radiation detector is either a solid-state radiation detector or a scintillator with a photodetector. The system images Cherenkov light emitted by tissue by using a timing signal synchronized to pulses of a pulsed radiation beam to control the PG-MPI camera by integrating light received by the PG-MPI camera during multiple pulses of the radiation beam while excluding light received by the camera between pulses of the radiation beam.
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4.发明申请公开(公告)号：US20200346041A1
公开(公告)日：2020-11-05
申请号：US16932757
申请日：2020-07-18
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
Inventor： Venkataramanan Krishnaswamy , Petr Bruza , Michael Jermyn , Brian W. Pogue
Abstract: A Cherenkov-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov radiation detection.
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公开(公告)号：US12036421B2
公开(公告)日：2024-07-16
申请号：US18563813
申请日：2022-05-25
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr Bruza , Brian Pogue , Ramish Ashraf , Rongxiao Zhang , David Gladstone , Megan Clark , Roman Vasyltsiv
IPC: A61N5/10
CPC classification number: A61N5/1031 , A61N5/1049 , A61N5/1067 , A61N5/1071 , A61N2005/1059
Abstract: A system for delivering ultra-high dose rate irradiation to a target area of a patient, includes a pulsed charged-particle source along a beam axis; a collimator for shaping the beam of radiation; one or more cameras for imaging the target area of the patient; and a dosimetry controller for providing control signals to the charged-particle source one or more dosimeters positioned between an output of the charged-particle source and the collimator in beam fringes for measuring a radiation dosage provided by each pulse; and a beam scanning coil positioned between the collimator and the patient for directing the shaped beam. The dosimetry controller receives feedback from the one or more dosimeters and provides control signals to the particle source and the beam scanning coil that modulate final pulses in the series of pulses in real-time.
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公开(公告)号：US11771323B2
公开(公告)日：2023-10-03
申请号：US17794297
申请日：2021-11-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr Bruza , Brian Pogue
CPC classification number: A61B5/0071 , G01N21/6408 , G01N21/6458
Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter-changer or tunable filter is between the tissue and the electronic camera with fluorescent imaging settings and a stimulus wavelength setting, and an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue.
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公开(公告)号：US11000703B2
公开(公告)日：2021-05-11
申请号：US16932757
申请日：2020-07-18
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
Inventor： Venkataramanan Krishnaswamy , Petr Bruza , Michael Jermyn , Brian W. Pogue
Abstract: A Cherenkov-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov radiation detection.
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