公开(公告)号：US11781955B2

公开(公告)日：2023-10-10

申请号：US17026724

申请日：2020-09-21

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Hisataka Kobayashi ,  Peter Choyke ,  Martin John Schnermann

IPC分类号： G01N1/44 ,  A61K47/68 ,  A61K49/00 ,  A61K41/00 ,  A61N5/06 ,  G01N1/40 ,  G01N33/50

CPC分类号： G01N1/44 ,  A61K41/0071 ,  A61K47/6891 ,  A61K49/0036 ,  A61N5/062 ,  G01N1/405 ,  G01N33/5002 ,  A61N2005/0651 ,  A61N2005/0663

摘要： This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule, to one that is hydrophobic, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory.

公开(公告)号：US10830678B2

公开(公告)日：2020-11-10

申请号：US15318104

申请日：2015-08-07

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Hisataka Kobayashi ,  Peter Choyke ,  Martin John Schnermann

IPC分类号： G01N1/44 ,  A61N5/06 ,  G01N1/40 ,  G01N33/50 ,  A61K49/00 ,  A61K41/00 ,  A61K47/68

摘要： This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule, to one that is hydrophobic, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory.

公开(公告)号：US10280307B2

公开(公告)日：2019-05-07

申请号：US15524567

申请日：2014-11-05

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Martin John Schnermann ,  Roger Rauhauser Nani ,  James Blaine Shaum

IPC分类号： A61K49/00 ,  C09B23/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C09K11/06 ,  G01N33/58

摘要： Embodiments of C4′-alkyl-ether heptamethine cyanine fluorophores according to general formula I, and pharmaceutically acceptable salts thereof, are disclosed. Methods of making and using the C4′-alkyl-ether heptamethine cyanine fluorophores also are disclosed.

公开(公告)号：US10561729B2

公开(公告)日：2020-02-18

申请号：US16323747

申请日：2017-08-07

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Martin John Schnermann ,  Roger Rauhauser Nani ,  Alexander Patrick Gorka

IPC分类号： A61K49/00 ,  A61K31/4545 ,  C07D209/10 ,  A61K41/00 ,  A61P35/00 ,  A61K47/54 ,  A61K47/68

摘要： Embodiments of near-infrared light-cleavable heptamethine cyanine-based conjugates, particularly targeting agent-drug conjugates, according to Formula I and conjugate precursors are disclosed. The disclosed targeting agent-drug conjugates are useful for targeted delivery and release of a drug. Methods of making and using the conjugates and precursors also are disclosed.