公开(公告)号：US20190153137A1

公开(公告)日：2019-05-23

申请号：US16313292

申请日：2017-06-28

Applicant: NOF CORPORATION ,  THE UNIVERSITY OF TOKYO

Inventor： Kazuhiko ISHIHARA ,  Masaru MATSUDA ,  Tomozumi NODA ,  Satoshi YAMADA ,  Nobuyuki SAKAMOTO

IPC: C08F230/02 ,  C08F212/08 ,  C08F220/18 ,  C08J3/28 ,  A61L27/34

Abstract: Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.

公开(公告)号：US20140170331A1

公开(公告)日：2014-06-19

申请号：US14186183

申请日：2014-02-21

Applicant: KYOCERA Medical Corporation ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  THE UNIVERSITY OF TOKYO

Inventor： Masayuki KYOMOTO ,  Kazuhiko ISHIHARA ,  Yasuhiko IWASAKI ,  Toru MORO ,  Kozo NAKAMURA ,  Yoshio TAKATORI ,  Hiroshi KAWAGUCHI ,  Tomohiro KONNO ,  Noboru YAMAWAKI

IPC: A61L27/34 ,  B05D3/06 ,  B05D1/18

CPC classification number: A61L27/34 ,  A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2002/30685 ,  A61F2002/30934 ,  A61F2002/3611 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61L27/42 ,  B05D1/18 ,  B05D3/067 ,  B23K35/3618 ,  C22F1/11 ,  C22F1/183 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/31536

Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Abstract translation: 本发明的目的是提供一种关节假体，轴承材料及其制造方法，其抑制滑动部分的磨损，并且即使在重复的日常操作中也抑制磨料粉末的生产。 为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合， 与基材的羟基和生物相容性材料层结合。

公开(公告)号：US20190256731A1

公开(公告)日：2019-08-22

申请号：US16315473

申请日：2017-07-05

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Kazuhiko ISHIHARA ,  Yoshihiro KIRITOSHI

IPC: C09D143/02 ,  C08F230/02 ,  C09K3/18

Abstract: [Problem] To provide a surface treatment polymer.[Solution] A compound represented by formula (1), and a surface treatment agent including the compound

公开(公告)号：US20210205495A1

公开(公告)日：2021-07-08

申请号：US15998921

申请日：2017-02-16

Applicant: KYOCERA Corporation ,  The University of Tokyo

Inventor： Shihori YAMANE ,  Masayuki KYOMOTO ,  Kazuhiko ISHIHARA

IPC: A61L27/34 ,  A61F2/34 ,  A61F2/30

Abstract: In a molding step as step A1, a polymer material is molded and a substrate having a predetermined shape is obtained. In a polymer film forming step as step A2, the obtained substrate is immersed in a treatment aqueous solution including a compound having a phosphorylcholine group and a water-soluble inorganic salt, and the substrate in that state is irradiated with an ultraviolet light to form on a surface of the substrate a polymer film including polymer chains caused by polymerization of the compound having a phosphorylcholine group. A method for manufacturing a sliding member for an artificial joint as mentioned above makes it possible to efficiently manufacture a sliding member for an artificial joint having excellent wear resistance.

公开(公告)号：US20190316054A1

公开(公告)日：2019-10-17

申请号：US16313515

申请日：2017-06-28

Applicant: NOF CORPORATION ,  THE UNIVERSITY OF TOKYO

Inventor： Kazuhiko ISHIHARA ,  Tomozumi NODA ,  Masaru MATSUDA ,  Satoshi YAMADA ,  Nobuyuki SAKAMOTO

IPC: C10M107/48 ,  C08F230/02

Abstract: Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.