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公开(公告)号：US11555082B2
公开(公告)日：2023-01-17
申请号：US16963864
申请日：2019-02-19
Applicant: TOKYO INSTITUTE OF TECHNOLOGY , STELLA PHARMA CORPORATION
Inventor： Nobuhiro Nishiyama , Takahiro Nomoto , Yukiya Inoue , Ying Yao , Kaito Kanamori , Hiroyasu Takemoto , Makoto Matsui , Keishiro Tomoda
Abstract: The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.
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公开(公告)号：US11376266B2
公开(公告)日：2022-07-05
申请号：US16067906
申请日：2017-01-05
Applicant: KEIO UNIVERSITY , TOKYO INSTITUTE OF TECHNOLOGY
Inventor： Hideyuki Saya , Osamu Nagano , Kenji Tsuchihashi , Kentaro Suina , Nobuhiro Nishiyama , Hiroyasu Takemoto , Takahiro Nomoto , Makoto Matsui , Keishiro Tomoda , Naoki Yamada , Tsukasa Nishimori
IPC: A61K31/635 , A61K47/60 , A61K9/00
Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.
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公开(公告)号：US11890347B2
公开(公告)日：2024-02-06
申请号：US16468199
申请日：2017-12-05
Applicant: Tokyo Institute of Technology
Inventor： Nobuhiro Nishiyama , Hiroyasu Takemoto , Abdul-Hackam Ranneh , Keishiro Tomoda , Takahiro Nomoto , Makoto Matsui
Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
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公开(公告)号：US20200069807A1
公开(公告)日：2020-03-05
申请号：US16468199
申请日：2017-12-05
Applicant: Tokyo Institute of Technology
Inventor： Nobuhiro Nishiyama , Hiroyasu Takemoto , Abdul-Hackam Ranneh , Keishiro Tomoda , Takahiro Nomoto , Makoto Matsui
Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
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Patent Agency Ranking
公开(公告)号：US12239713B2
公开(公告)日：2025-03-04
申请号：US17042039
申请日：2019-03-29
Applicant: NOF CORPORATION , TOKYO INSTITUTE OF TECHNOLOGY
Inventor： Hiroki Yoshioka , Masaki Kamiya , Yuji Yamamoto , Midori Hirai , Akiko Sasaki , Nobuhiro Nishiyama , Makoto Matsui , Hiroyasu Takemoto , Kazuki Miyauchi , Takahiro Nomoto , Keishiro Tomoda
Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.
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公开(公告)号：US12187846B2
公开(公告)日：2025-01-07
申请号：US17042711
申请日：2019-03-29
Applicant: NOF CORPORATION , TOKYO INSTITUTE OF TECHNOLOGY
Inventor： Hiroki Yoshioka , Masaki Kamiya , Yuji Yamamoto , Midori Hirai , Akiko Sasaki , Nobuhiro Nishiyama , Makoto Matsui , Hiroyasu Takemoto , Kazuki Miyauchi , Takahiro Nomoto , Keishiro Tomoda
IPC: C08G65/333 , A61K47/60 , A61K47/62 , A61K47/65 , C08G65/325 , C08L71/02
Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
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公开(公告)号：US20220265836A1
公开(公告)日：2022-08-25
申请号：US17613912
申请日：2020-05-29
Inventor： Nobuhiro Nishiyama , Yuto Honda , Takahiro Nomoto , Hiroyasu Takemoto , Makoto Matsui , Hiroaki Kinoh , Kazunori Kataoka , Xueying Liu , Anjaneyulu Dirisala
Abstract: A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate.
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8.发明授权公开(公告)号：US11707530B2
公开(公告)日：2023-07-25
申请号：US16326657
申请日：2017-08-17
Applicant: TOKYO INSTITUTE OF TECHNOLOGY , OSAKA UNIVERSITY
Inventor： Nobuhiro Nishiyama , Hiroyasu Takemoto , Takahiro Nomoto , Keishiro Tomoda , Makoto Matsui , Naoki Yamada , Yuto Honda , Hideshi Ishii , Masaki Mori , Masamitsu Konno
CPC classification number: A61K47/6455 , A61K49/146
Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.
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9.发明申请公开(公告)号：US20210308271A1
公开(公告)日：2021-10-07
申请号：US16326657
申请日：2017-08-17
Applicant: TOKYO INSTITUTE OF TECHNOLOGY , OSAKA UNIVERSITY
Inventor： Nobuhiro Nishiyama , Hiroyasu Takemoto , Takahiro Nomoto , Keishiro Tomoda , Makoto Matsui , Naoki Yamada , Yuto Honda , Hideshi Ishii , Masaki Mori , Masamitsu Konno
Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.
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