公开(公告)号：US11555082B2

公开(公告)日：2023-01-17

申请号：US16963864

申请日：2019-02-19

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  STELLA PHARMA CORPORATION

Inventor： Nobuhiro Nishiyama ,  Takahiro Nomoto ,  Yukiya Inoue ,  Ying Yao ,  Kaito Kanamori ,  Hiroyasu Takemoto ,  Makoto Matsui ,  Keishiro Tomoda

IPC: C08F8/42 ,  C08F16/06 ,  A61K47/60 ,  A61P35/00 ,  A61K9/00 ,  A61K31/69

Abstract: The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.

公开(公告)号：US11890347B2

公开(公告)日：2024-02-06

申请号：US16468199

申请日：2017-12-05

Applicant: Tokyo Institute of Technology

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Abdul-Hackam Ranneh ,  Keishiro Tomoda ,  Takahiro Nomoto ,  Makoto Matsui

IPC: A61K47/59 ,  C08G69/48

CPC classification number: A61K47/59 ,  C08G69/48

Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.

公开(公告)号：US20220339290A1

公开(公告)日：2022-10-27

申请号：US17763516

申请日：2020-09-25

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Ken Hamura ,  Hiroki Yoshioka ,  Kazuki Osakama ,  Nobuhiro Nishiyama

IPC: A61K47/64 ,  A61K47/60

Abstract: A branched degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A branched degradable polyethylene glycol derivative represented by the following formula (1), containing, in a molecule, an oligopeptide that is degraded in the cells: wherein k1 and k2 are each independently 1-12, j1 and j2 are each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and L1 and L2 are each independently a single bond or a divalent spacer.

公开(公告)号：US20200069807A1

公开(公告)日：2020-03-05

申请号：US16468199

申请日：2017-12-05

Applicant: Tokyo Institute of Technology

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Abdul-Hackam Ranneh ,  Keishiro Tomoda ,  Takahiro Nomoto ,  Makoto Matsui

IPC: A61K47/59 ,  C08G69/48

Abstract: A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.

公开(公告)号：US11707530B2

公开(公告)日：2023-07-25

申请号：US16326657

申请日：2017-08-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC: A61K47/64 ,  A61K49/14

CPC classification number: A61K47/6455 ,  A61K49/146

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：US20210308271A1

公开(公告)日：2021-10-07

申请号：US16326657

申请日：2017-08-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC: A61K47/64 ,  A61K49/14

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：US20170258922A1

公开(公告)日：2017-09-14

申请号：US15503370

申请日：2015-08-11

Applicant: The University of Tokyo ,  Tokyo Institute of Technology

Inventor： Hiroaki Kinoh ,  Kazunori Kataoka ,  Horacio Cabral ,  Yutaka Miura ,  Shigeto Fukushima ,  Nobuhiro Nishiyama ,  Tsukasa Chida

IPC: A61K9/127 ,  A61K31/553 ,  A61K31/4545 ,  A61K31/475 ,  A61K31/704 ,  A61K31/4402 ,  A61K47/48 ,  C08L77/04

CPC classification number: A61K31/4402 ,  A61K9/0019 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/475 ,  A61K31/553 ,  A61K31/704 ,  A61K45/06 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6907 ,  A61K2300/00

Abstract: The problem addressed by the present invention is to develop a pharmaceutical having therapeutic efficacy against epirubicin-resistant tumors. The present invention provides a micelle having an anti-cancer agent disposed inside the core of the micelle formed by an epirubicin-conjugated copolymer.

公开(公告)号：US11376266B2

公开(公告)日：2022-07-05

申请号：US16067906

申请日：2017-01-05

Applicant: KEIO UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideyuki Saya ,  Osamu Nagano ,  Kenji Tsuchihashi ,  Kentaro Suina ,  Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Makoto Matsui ,  Keishiro Tomoda ,  Naoki Yamada ,  Tsukasa Nishimori

IPC: A61K31/635 ,  A61K47/60 ,  A61K9/00

Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.

公开(公告)号：US10220026B2

公开(公告)日：2019-03-05

申请号：US15503370

申请日：2015-08-11

Applicant: The University of Tokyo ,  Tokyo Institute of Technology

Inventor： Hiroaki Kinoh ,  Kazunori Kataoka ,  Horacio Cabral ,  Yutaka Miura ,  Shigeto Fukushima ,  Nobuhiro Nishiyama ,  Tsukasa Chida

IPC: A61K31/4402 ,  A61K31/4545 ,  A61K31/475 ,  A61K31/553 ,  A61K31/704 ,  A61K31/4375 ,  A61K47/48 ,  A61K9/00 ,  A61K45/06 ,  A61K47/60 ,  A61K47/59 ,  A61K47/69

Abstract: The problem addressed by the present invention is to develop a pharmaceutical having therapeutic efficacy against epirubicin-resistant tumors. The present invention provides a micelle having an anti-cancer agent disposed inside the core of the micelle formed by an epirubicin-conjugated copolymer.

公开(公告)号：US12239713B2

公开(公告)日：2025-03-04

申请号：US17042039

申请日：2019-03-29

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki Yoshioka ,  Masaki Kamiya ,  Yuji Yamamoto ,  Midori Hirai ,  Akiko Sasaki ,  Nobuhiro Nishiyama ,  Makoto Matsui ,  Hiroyasu Takemoto ,  Kazuki Miyauchi ,  Takahiro Nomoto ,  Keishiro Tomoda

IPC: A61K47/60 ,  A61K38/19 ,  A61K38/23 ,  A61K38/27 ,  C07K5/103 ,  C07K7/06 ,  C07K19/00 ,  C08G65/333

Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.