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公开(公告)号：US20170191123A1
公开(公告)日：2017-07-06
申请号：US15314288
申请日：2015-05-28
Applicant: TOOLGEN INCORPORATED , INSTITUTE FOR BASIC SCIENCE
Inventor： Jin Soo Kim , So Jung Kim , Seung Hwan Lee , Seok Joong Kim
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/68 , C12Q2521/301 , G01N33/53 , G01N33/574
Abstract: The present invention relates to a method for analyzing a genotype using a target-specific nuclease and, specifically, to a method for diagnosing cancer or analyzing a genotype by removing wild type DNA or particular genotype DNA using a target-specific nuclease or a variant thereof to amplify or concentrate only a small amount of DNA which has a difference in variation, such as a mutation, or genotype, and to a method for separating target DNA sesusing a target-specific nuclease or a variant thereof. Such methods are novel paradigm methods contrary to existing simple target-specific nucleases for post-PCR recognition of normal genotype and carcinogenic genotype, and can be favorably used in the early diagnosis of cancer or analysis of similar genotypes.
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公开(公告)号：US20240301424A1
公开(公告)日：2024-09-12
申请号：US18657145
申请日：2024-05-07
Applicant: Toolgen Incorporated
Inventor： Seok Joong Kim , Yoon-Young Kim , Ho-Sung Yu , In-Young Jung , Jung Min Lee
IPC: C12N15/113 , A61K35/14 , C07K14/705 , C12N5/0783 , C12N5/0784 , C12N9/22 , C12N15/10 , C12N15/52 , C12N15/63 , C12N15/85
CPC classification number: C12N15/1132 , A61K35/14 , C07K14/70503 , C07K14/70564 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0646 , C12N15/102 , C12N15/1138 , C12N15/52 , C12N15/63 , C12N15/85 , C12N9/22 , C12N2310/20 , C12N2320/30 , Y02A50/30
Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof
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公开(公告)号：US20170145425A1
公开(公告)日：2017-05-25
申请号：US15420936
申请日：2017-01-31
Applicant: TOOLGEN INCORPORATED
Inventor： Eun Ji Kim , Seok Joong Kim
CPC classification number: C12N15/63 , C12N7/00 , C12N9/16 , C12N15/86 , C12N2750/14143
Abstract: The disclosure provided herewith relates to a Campylobacter jejuni CRISPR/CAS system-derived RGEN and a use thereof.
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Patent Agency Ranking
4.发明授权公开(公告)号：US12286635B2
公开(公告)日：2025-04-29
申请号：US17706921
申请日：2022-03-29
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong Kim , Ok Jae Koo , Min Hee Jung , Ye Seul Kim
Abstract: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.
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公开(公告)号：US20200172912A1
公开(公告)日：2020-06-04
申请号：US16700942
申请日：2019-12-02
Applicant: TOOLGEN INCORPORATED
Inventor： Eun Ji Kim , Seok Joong Kim
Abstract: The disclosure provided herewith relates to a Campylobacter jejuni CRISPR/CAS system-derived RGEN and a use thereof.
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公开(公告)号：US12275963B2
公开(公告)日：2025-04-15
申请号：US16611383
申请日：2018-05-08
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong Kim , Yoon-Young Kim , Ho-Sung Yu , In-Young Jung , Jung Min Lee
IPC: A61K39/00 , C07K14/705 , C07K16/28 , C12N5/078 , C12N5/0783 , C12N9/22 , C12N15/10 , C12N15/113 , C12N15/115 , C12N15/117 , C12N15/87 , C07K14/725
Abstract: The presents invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell. More particularly, the present invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell and a manipulated immune cell comprising an artificially modified immunity regulating gene and an artificial receptor which is produced using the composition, and use thereof.
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公开(公告)号：US12012598B2
公开(公告)日：2024-06-18
申请号：US16324955
申请日：2017-08-14
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong Kim , Yoon-Young Kim , Ho-Sung Yu , In-Young Jung , Jung Min Lee
IPC: C12N15/113 , A61K35/14 , C07K1/00 , C07K14/705 , C12N5/0783 , C12N5/0784 , C12N15/10 , C12N15/52 , C12N15/63 , C12N15/85 , A61K31/70 , C12N9/22
CPC classification number: C12N15/1132 , A61K35/14 , C07K14/70503 , C07K14/70564 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0646 , C12N15/102 , C12N15/1138 , C12N15/52 , C12N15/63 , C12N15/85 , C12N9/22 , C12N2310/20 , C12N2320/30 , Y02A50/30
Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.
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公开(公告)号：US10519454B2
公开(公告)日：2019-12-31
申请号：US15420936
申请日：2017-01-31
Applicant: TOOLGEN INCORPORATED
Inventor： Eun Ji Kim , Seok Joong Kim
Abstract: The disclosure provided herewith relates to a Campylobacter jejuni CRISPR/CAS system-derived RGEN and a use thereof.
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