公开(公告)号：US20160256604A1

公开(公告)日：2016-09-08

申请号：US15027468

申请日：2014-10-06

申请人： TRUSTEES OF TUFTS COLLEGE

发明人： Craig W. Hanna ,  Benjamin P. Partlow ,  David L. Kaplan

IPC分类号： A61L27/22 ,  C12P21/00 ,  A61L27/50 ,  A61L27/54 ,  A61L27/52 ,  A61L27/38

CPC分类号： A61L27/227 ,  A61K9/0019 ,  A61K9/06 ,  A61K35/00 ,  A61K47/42 ,  A61K47/46 ,  A61L27/18 ,  A61L27/20 ,  A61L27/22 ,  A61L27/3604 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/64 ,  A61L2400/06 ,  C07K14/43586 ,  C08J3/075 ,  C08J2389/00 ,  C12P21/00 ,  C08L67/04

摘要： The present invention provides, among other things, a elastomeric biomaterial having enzymatically cross-linked amino acid phenolic side chains to generate highly elastic hydrogels. Materials are characterized by tunable mechanical properties, gelation kinetics and swelling properties of these new protein polymers. Provided materials are support encapsulation of cells. Methods of making and using of provided particles are also disclosed.

摘要翻译： 本发明尤其提供了具有酶交联的氨基酸酚侧链以产生高弹性水凝胶的弹性体生物材料。 材料的特征在于这些新蛋白质聚合物的可调谐机械性能，凝胶化动力学和溶胀性能。 提供的材料是支持细胞的包封。 还公开了制备和使用所提供的颗粒的方法。

公开(公告)号：US10925999B2

公开(公告)日：2021-02-23

申请号：US15027468

申请日：2014-10-06

申请人： TRUSTEES OF TUFTS COLLEGE

发明人： Craig W. Hanna ,  Benjamin P. Partlow ,  David L. Kaplan

IPC分类号： A61L27/22 ,  A61L27/50 ,  A61L27/52 ,  A61K9/00 ,  A61K47/46 ,  A61L27/58 ,  C07K14/435 ,  A61K47/42 ,  A61K9/06 ,  A61L27/18 ,  A61K35/00 ,  A61L27/20 ,  A61L27/36 ,  C08J3/075 ,  A61L27/38 ,  A61L27/54 ,  C12P21/00

摘要： The present invention provides, among other things, a elastomeric biomaterial having enzymatically cross-linked amino acid phenolic side chains to generate highly elastic hydrogels. Materials are characterized by tunable mechanical properties, gelation kinetics and swelling properties of these new protein polymers. Provided materials are support encapsulation of cells. Methods of making and using of provided particles are also disclosed.