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公开(公告)号：US4618687A
公开(公告)日：1986-10-21
申请号：US724549
申请日：1985-04-18
申请人： Tadashi Hirata , Hiromitsu Saito , Makoto Morimoto
发明人： Tadashi Hirata , Hiromitsu Saito , Makoto Morimoto
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/94
CPC分类号： C07D311/94
摘要： A cyclopentenone compound represented by the following formula: ##STR1## has an antitumor effect and can be produced from the antibiotic XK-213.
摘要翻译： 由下式表示的环戊烯酮化合物：
具有抗肿瘤作用，可由抗生素XK-213生产。 -
公开(公告)号：US4946957A
公开(公告)日：1990-08-07
申请号：US400883
申请日：1989-08-30
申请人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/495 , A61P31/04 , C07D471/18 , C07D498/22
CPC分类号： C07D471/18 , C07D498/22
摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.
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公开(公告)号：US4822882A
公开(公告)日：1989-04-18
申请号：US102359
申请日：1987-09-29
申请人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： C07D471/18 , C07D498/22 , A61K31/495 , C07D487/18
CPC分类号： C07D471/18 , C07D498/22
摘要： Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.
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公开(公告)号：US4879386A
公开(公告)日：1989-11-07
申请号：US207639
申请日：1988-05-25
申请人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/495 , A61P31/04 , C07D471/18 , C07D498/22
CPC分类号： C07D471/18 , C07D498/22
摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## ps [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.
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公开(公告)号：US5084468A
公开(公告)日：1992-01-28
申请号：US392271
申请日：1989-08-10
申请人： Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
发明人： Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
IPC分类号： C07D487/04 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10
摘要： A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.
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公开(公告)号：US5008271A
公开(公告)日：1991-04-16
申请号：US423788
申请日：1989-10-18
申请人： Yutaka Kanda , Tohru Yasuzawa , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto
发明人： Yutaka Kanda , Tohru Yasuzawa , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto
IPC分类号： C07D471/04 , C07D487/04 , C07D487/10
CPC分类号： C07D471/04 , C07D487/04 , C07D487/10
摘要： A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.
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公开(公告)号：US5071984A
公开(公告)日：1991-12-10
申请号：US612487
申请日：1990-11-14
申请人： Hiromitsu Saito , Akira Sato , Masaji Kasai , Makoto Morimoto , Tadashi Ashizawa
发明人： Hiromitsu Saito , Akira Sato , Masaji Kasai , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/495 , A61P31/04 , A61P35/00 , C07D471/18 , C07D498/22
CPC分类号： C07D471/18 , C07D498/22
摘要： Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.
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公开(公告)号：US5070092A
公开(公告)日：1991-12-03
申请号：US545579
申请日：1990-06-29
申请人： Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
发明人： Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
IPC分类号： A61K31/40 , A61K31/445 , A61K31/495 , A61P35/00 , C07D487/04 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10
摘要： DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.
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公开(公告)号：US4343943A
公开(公告)日：1982-08-10
申请号：US51758
申请日：1979-06-25
IPC分类号： C07D463/00 , C07F9/40 , C07F9/568 , C07D211/80
CPC分类号： C07F9/5683 , C07D463/16 , C07D463/22 , C07F9/4006
摘要： Novel cephalosporin analogs and intermediates therefor are useful as antibiotics. Methods for producing the compounds are provided.
摘要翻译： 新型头孢菌素类似物及其中间体可用作抗生素。 提供了制备化合物的方法。
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公开(公告)号：US4291164A
公开(公告)日：1981-09-22
申请号：US23645
申请日：1979-03-23
IPC分类号： C07D463/00 , C07D501/18 , C07F9/568 , C07D221/02
CPC分类号： C07F9/5683 , C07D463/06
摘要： Novel cephalosporin analogs are disclosed which are useful as intermediates in the production of other compounds having antibacterial activity. Methods for producing the compounds are also disclosed.
摘要翻译： 公开了新的头孢菌素类似物，其可用作生产具有抗菌活性的其它化合物的中间体。 还公开了制备化合物的方法。
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