公开(公告)号：US20080107600A1

公开(公告)日：2008-05-08

申请号：US10545564

申请日：2004-02-12

申请人： Taiichi Katayama ,  Takeshi Miyoshi ,  Masaya Tohyama ,  Kousuke Baba ,  Akiko Honda

发明人： Taiichi Katayama ,  Takeshi Miyoshi ,  Masaya Tohyama ,  Kousuke Baba ,  Akiko Honda

IPC分类号： A61K45/00 ,  C07K2/00 ,  C07H21/00 ,  C07K14/00 ,  A61P25/18 ,  A61P25/00 ,  G01N33/566 ,  C12Q1/68 ,  G01N33/68

CPC分类号： G01N33/6896 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2500/20 ,  G01N2800/28

摘要： The present invention provides a marker, kit and method for determining the level of axon outgrowth and/or fasciculation, or conditions, disorders or diseases associated with the level of axon outgrowth and/or fasciculation. The present invention was achieved by unexpectedly finding the relationship between DISC1 and FEZ1 and KIAA0844 and unexpectedly finding that axon outgrowth and/or fasciculation are not normally conducted if the normal binding therebetween was inhibited. Therefore, the present invention relates to an agent specifically interacting with DISC1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, and an agent specifically binding KIAA0844 and a gene product thereof.

摘要翻译： 本发明提供了一种用于确定与轴突生长和/或束缚水平相关的轴突生长和/或引导或条件，紊乱或疾病的水平的标记物，试剂盒和方法。 本发明通过意外地发现DISC1与FEZ1和KIAA0844的关系而意外地发现，如果其间的正常结合被抑制，则通常不会进行轴突向外生长和/或成像。 因此，本发明涉及与DISC1及其基因产物特异性结合的试剂，特异性结合FEZ1及其基因产物，特异性结合FEZ1及其基因产物的试剂，以及特异性结合KIAA0844和基因的试剂 其产品。

公开(公告)号：US08610586B2

公开(公告)日：2013-12-17

申请号：US12736233

申请日：2009-03-18

申请人： Yoshitake Shimada ,  Mikio Komatsu ,  Koji Sakamoto ,  Hirohisa Okuno ,  Akiko Honda ,  Koji Yamato

发明人： Yoshitake Shimada ,  Mikio Komatsu ,  Koji Sakamoto ,  Hirohisa Okuno ,  Akiko Honda ,  Koji Yamato

IPC分类号： G08B21/00

CPC分类号： G08B17/10 ,  G08B17/113

摘要： A sensor having a detecting part for detecting an environmental value representing change in physical amount of circumference environment by a fluid flowing into externally and a controlling part for discriminating abnormality in circumference environment based on the environmental value detected by the detecting part. A separating plate is provided inside a housing so as to separate two spaces in the height direction. A detection unit is provided in one space and a sounding body is provided in the other space. Apertures are provided in a side wall, thereby opening one space to the outside environment and letting the fluid to be measured flow into the space. Then, a flow path is formed inside the space in the housing, from the side wall forming the housing toward the detection unit, thereby proactively channeling the fluid to the detection unit.

摘要翻译： 一种传感器，具有检测部，其检测表示流入外部的流体的周围环境物理量的变化的环境值，以及基于由检测部检测出的环境值，判断周围环境的异常的控制部。 分离板设置在壳体内部，以在高度方向上分离两个空间。 检测单元设置在一个空间中，并且在另一空间中设置探测体。 孔设置在侧壁中，从而向外部环境打开一个空间并且使被测量的流体流入空间。 然后，从形成壳体的侧壁朝向检测单元，在壳体的空间内形成流路，从而主动地将流体引导到检测单元。

公开(公告)号：US20070243560A1

公开(公告)日：2007-10-18

申请号：US11812334

申请日：2007-06-18

申请人： Masaya Yamanouchi ,  Akiko Honda ,  Hiromi Hase ,  Takeshi Sugaya ,  Kenjiro Kimura

发明人： Masaya Yamanouchi ,  Akiko Honda ,  Hiromi Hase ,  Takeshi Sugaya ,  Kenjiro Kimura

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2800/347

摘要： Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results which may be very important information for diagnosis of prognosis of kidney disease, that has been very difficult in the past. Based on test results obtained by the present method, it may be possible to select a suitable method for treatment of kidney disease with taking into consideration risks as to the prognosis, etc. Besides, the present method can be applied to, in addition to the kidney tissue samples, urine samples as well, so that the examination procedure can be simple and efficient.

摘要翻译： 用于检查肾脏疾病的方法，其包括检测来自肾组织的脂肪酸结合蛋白，其存在于不包括啮齿动物的哺乳动物收集的标本中。 通过本方法，可以获得可能是诊断肾脏疾病预后的非常重要的信息的测试结果，这在过去是非常困难的。 根据本方法得到的检测结果，考虑到预后的风险等，可以选择合适的肾病治疗方法。此外，本方法除了可以应用于 肾组织样本，尿液样本，使检查程序简单有效。

公开(公告)号：US06803117B2

公开(公告)日：2004-10-12

申请号：US10166880

申请日：2002-06-11

申请人： Hideyuki Akimoto ,  Kenji Sato ,  Yuki Yoshida ,  Masaya Suzuki ,  Akira Kikuchi ,  Tohru Horie ,  Naoya Saito ,  Akiko Honda

发明人： Hideyuki Akimoto ,  Kenji Sato ,  Yuki Yoshida ,  Masaya Suzuki ,  Akira Kikuchi ,  Tohru Horie ,  Naoya Saito ,  Akiko Honda

IPC分类号： G11B565

CPC分类号： G11B5/7315 ,  G11B5/66 ,  G11B5/7325 ,  G11B5/84 ,  Y10T428/12646 ,  Y10T428/12833 ,  Y10T428/1284 ,  Y10T428/12854 ,  Y10T428/12931 ,  Y10T428/24355 ,  Y10T428/24537 ,  Y10T428/24975 ,  Y10T428/265 ,  Y10T428/31

摘要： A magnetic recording medium for high areal recording density that has excellent thermal fluctuation resistance and recording/reproduction characteristics, and a method of producing the same. The magnetic recording medium includes a glass substrate, an NiP layer having an oxide film on its surface provided on the glass substrate, a ground layer provided on the NiP layer, and a nonmagnetic intermediate layer provided on the ground layer. The magnetic recording medium further includes an exchange layer structure composed of a ferromagnetic layer and a nonmagnetic coupling layer provided on the nonmagnetic intermediate layer, and a magnetic recording layer provided on the exchange layer structure. The oxide film on the NiP layer is formed by introducing a small quantity of oxygen into a vacuum chamber of a sputter device. The formation and oxidation of the NiP layer are conducted at a temperature of not less than 140° C.

摘要翻译： 一种具有优异的耐热波动性和记录/再现特性的高面积记录密度的磁记录介质及其制造方法。 磁记录介质包括玻璃基板，在玻璃基板上的表面上具有氧化膜的NiP层，设置在NiP层上的接地层和设置在接地层上的非磁性中间层。 磁记录介质还包括由铁磁层和设置在非磁性中间层上的非磁性耦合层构成的交换层结构，以及设置在交换层结构上的磁记录层。 通过将少量氧气引入溅射装置的真空室中，形成NiP层上的氧化物膜。 NiP层的形成和氧化在不低于140℃的温度下进行。

公开(公告)号：US20110068936A1

公开(公告)日：2011-03-24

申请号：US12736233

申请日：2009-03-18

申请人： Yoshitake Shimada ,  Mikio Komatsu ,  Koji Sakamoto ,  Hirohisa Okuno ,  Akiko Honda ,  Koji Yamato

发明人： Yoshitake Shimada ,  Mikio Komatsu ,  Koji Sakamoto ,  Hirohisa Okuno ,  Akiko Honda ,  Koji Yamato

IPC分类号： G08B17/00 ,  G01F1/684 ,  G01N21/00

CPC分类号： G08B17/10 ,  G08B17/113

摘要： A sensor having a detecting part for detecting an environmental value representing change in physical amount of circumference environment by a fluid flowing into externally and a controlling part for discriminating abnormality in circumference environment based on the environmental value detected by the detecting part. A separating plate is provided inside a housing so as to separate two spaces in the height direction. A detection unit is provided in one space and a sounding body is provided in the other space. Apertures are provided in a side wall, thereby opening one space to the outside environment and letting the fluid to be measured flow into the space. Then, a flow path is formed inside the space in the housing, from the side wall forming the housing toward the detection unit, thereby proactively channeling the fluid to the detection unit.

摘要翻译： 一种传感器，具有检测部，其检测表示流入外部的流体的周围环境物理量的变化的环境值，以及基于由检测部检测出的环境值，判断周围环境的异常的控制部。 分离板设置在壳体内部，以在高度方向上分离两个空间。 检测单元设置在一个空间中，并且在另一空间中设置探测体。 孔设置在侧壁中，从而向外部环境打开一个空间并且使被测量的流体流入空间。 然后，从形成壳体的侧壁朝向检测单元，在壳体的空间内形成流路，从而主动地将流体引导到检测单元。

公开(公告)号：US5383431A

公开(公告)日：1995-01-24

申请号：US24778

申请日：1993-03-02

申请人： Eiji Nishimura ,  Akiko Honda

发明人： Eiji Nishimura ,  Akiko Honda

IPC分类号： F02D9/02 ,  F02D11/10 ,  F02D41/04 ,  F02D41/10

CPC分类号： F02D11/105 ,  F02D2011/102

摘要： A throttle actuator opens and closes the throttle valve of an engine in response to movement of an accelerator pedal. Throttle opening characteristics which determines a target throttle opening for a given amount of depression of the accelerator pedal is set so that the accelerator depression fluctuation rate is minimized when the power mode is selected and so that the fuel consumption rate is minimized when the economy mode is selected.

摘要翻译： 节气门执行器响应于加速踏板的运动而打开和关闭发动机的节气门。 设定确定加速器踏板的给定量的下压的目标节气门开度的节气门开度特性，使得当选择功率模式时，加速器下降波动率最小化，并且当经济模式为 选择。

公开(公告)号：US07592148B1

公开(公告)日：2009-09-22

申请号：US09578693

申请日：2000-07-26

申请人： Masaya Yamanouchi ,  Akiko Honda ,  Hiromi Hase ,  Takeshi Sugaya ,  Kenjiro Kimura

发明人： Masaya Yamanouchi ,  Akiko Honda ,  Hiromi Hase ,  Takeshi Sugaya ,  Kenjiro Kimura

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： G01N33/6893 ,  G01N2800/347

摘要： Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results, which may be very important information for diagnosis or prognosis of kidney disease that has been very difficult in the past. Based on test results obtained by the present method, it may be possible to select a suitable method for treatment of kidney disease with taking into consideration risks such as the prognosis, etc. Besides, the present method can be applied to, in addition to the kidney disease samples, urine samples as well, so that the examination procedure can be simple and efficient.

摘要翻译： 用于检查肾脏疾病的方法，其包括检测来自肾组织的脂肪酸结合蛋白，其存在于不包括啮齿动物的哺乳动物收集的标本中。 通过本方法，可以获得测试结果，这可能是过去非常困难的肾脏疾病的诊断或预后的非常重要的信息。 根据本方法得到的检测结果，考虑到预后等风险，可以选择合适的肾脏疾病治疗方法。此外，本方法除了可以应用于 肾脏疾病样本，尿液样本，使检查程序简单有效。

公开(公告)号：US06794154B1

公开(公告)日：2004-09-21

申请号：US09979765

申请日：2001-11-27

申请人： Masaya Yamanouchi ,  Hiromi Hase ,  Akiko Honda ,  Takeshi Sugaya

发明人： Masaya Yamanouchi ,  Hiromi Hase ,  Akiko Honda ,  Takeshi Sugaya

IPC分类号： G01N3353

CPC分类号： C12N5/0686 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K31/00 ,  A61K31/336 ,  A61K31/41 ,  A61K31/425 ,  A61K31/4439 ,  A61K38/00 ,  C07K14/475 ,  C07K14/705 ,  C12N15/8509 ,  C12N2503/02 ,  C12N2510/04 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/92 ,  G01N2500/00 ,  G01N2500/10

摘要： The present invention provides a method for screening or identifying therapeutic or prophylactic agents for renal diseases, which comprises assaying a test substance for the activity of up-regulating the expression of fatty acid-binding protein (FABP), and novel mouse proximal renal tubular epithelial cell lines useful therein. The present invention also provides therapeutic or prophylactic agents for renal diseases comprising, as an active ingredient, an agent having activity of up-regulating FABP expression; agents for up-regulating the expression of FABP, and for treating or preventing renal diseases, which comprise a compound having activity of peroxisome proliferator-activated receptor (PPAR) agonist or carnitine palmitoyltransferase (CPT) inhibitor or the like.

摘要翻译： 本发明提供了筛选或鉴定肾脏疾病的治疗或预防剂的方法，其包括测定测试物质以上调脂肪酸结合蛋白（FABP）表达的活性，以及​​新型小鼠近端肾小管上皮 可用于其中的细胞系。 本发明还提供了用于肾脏疾病的治疗剂或预防剂，其包含作为活性成分的具有上调FABP表达活性的药剂; 用于上调FABP表达的药物，以及用于治疗或预防肾脏疾病的药物，其包含具有过氧化物酶体增殖物激活受体（PPAR）激动剂或肉碱棕榈酰转移酶（CPT）抑制剂等的活性的化合物。