-
1.发明申请Gene Marker And Composition For Diagnosis And Treatment Of Neurological Disorders And Diseases And Use Of The Same 审中-公开基因标记和组成用于诊断和治疗神经系统疾病和疾病及其使用公开(公告)号：US20080107600A1
公开(公告)日：2008-05-08
申请号：US10545564
申请日：2004-02-12
申请人： Taiichi Katayama , Takeshi Miyoshi , Masaya Tohyama , Kousuke Baba , Akiko Honda
发明人： Taiichi Katayama , Takeshi Miyoshi , Masaya Tohyama , Kousuke Baba , Akiko Honda
IPC分类号： A61K45/00 , C07K2/00 , C07H21/00 , C07K14/00 , A61P25/18 , A61P25/00 , G01N33/566 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2500/20 , G01N2800/28
摘要： The present invention provides a marker, kit and method for determining the level of axon outgrowth and/or fasciculation, or conditions, disorders or diseases associated with the level of axon outgrowth and/or fasciculation. The present invention was achieved by unexpectedly finding the relationship between DISC1 and FEZ1 and KIAA0844 and unexpectedly finding that axon outgrowth and/or fasciculation are not normally conducted if the normal binding therebetween was inhibited. Therefore, the present invention relates to an agent specifically interacting with DISC1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, and an agent specifically binding KIAA0844 and a gene product thereof.
摘要翻译： 本发明提供了一种用于确定与轴突生长和/或束缚水平相关的轴突生长和/或引导或条件，紊乱或疾病的水平的标记物，试剂盒和方法。 本发明通过意外地发现DISC1与FEZ1和KIAA0844的关系而意外地发现，如果其间的正常结合被抑制，则通常不会进行轴突向外生长和/或成像。 因此，本发明涉及与DISC1及其基因产物特异性结合的试剂，特异性结合FEZ1及其基因产物，特异性结合FEZ1及其基因产物的试剂，以及特异性结合KIAA0844和基因的试剂 其产品。
-
公开(公告)号：US5100655A
公开(公告)日：1992-03-31
申请号：US647206
申请日：1991-01-28
CPC分类号： A61K8/06 , A61K8/44 , A61Q19/00 , C07D279/14 , A61Q5/02 , A61Q5/12 , Y10S514/937 , Y10S514/938 , Y10S516/06 , Y10S516/07
摘要： Emulsifier compositions capable of forming an emulsion which is stable over a wide range of temperatures and contains at least one of a N.sup..alpha. -long-chain acyl arginine higher alkyl ester of the general formula (I) or an acid-addition salt thereof: ##STR1## wherein R.sup.1 CO is a straight-chain C.sub.8-22 acyl group; and R.sup.2 is a straight-chain or branched C.sub.12-22 alkyl group, are disclosed.
-
3.发明授权Method of stabilizing a UVB absorbing compound, a stabilized UV absorber, and a cosmetic composition containing the same 失效使UVB吸收化合物稳定化的方法，稳定化的紫外线吸收剂以及含有它们的化妆品组合物
公开(公告)号：US5000945A
公开(公告)日：1991-03-19
申请号：US242166
申请日：1988-09-08
CPC分类号： A61Q17/04 , A61K8/37 , A61K8/445 , A61K8/4946 , A61Q1/02 , A61Q1/06 , Y10S424/01 , Y10S424/02 , Y10S514/844 , Y10S514/845 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/972
摘要： A process for stabilizing a specific UVB absorbing compound which comprises adding to said UVB absorbing compound at least one specific UVA absorbing compound in an amount of 0.1-10 parts by weight based on 1 part by weight of UVB absorbing compound is disclosed and also a cosmetic composition and a UV absorber, both containing said specific UVB absorbing compound and said specific UVA absorbing compound, respectively.
摘要翻译： 一种用于稳定特定UVB吸收化合物的方法，其包括向所述UVB吸收化合物中加入至少一种基于1重量份的UVB吸收化合物为0.1-10重量份的特定UVA吸收化合物，并且还包括化妆品 组合物和UV吸收剂，其分别含有所述特定的UVB吸收化合物和所述特定的UVA吸收化合物。
-
公开(公告)号：US5992857A
公开(公告)日：1999-11-30
申请号：US822462
申请日：1997-03-21
CPC分类号： F16J15/122 , F16J15/104 , Y10S277/938 , Y10S277/946
摘要： The composite gasket of the present invention has improved various properties which are different depending on use conditions, while ensuring sealing properties, by combining a seal material which is selected in accordance with the properties of certain sheet-like seal materials in a substrate. The composite gasket is configured by forming a plurality of slits in a surface of the sheet-like seal materials the slits extending in a thickness direction of the materials, and loading a seal material composed of a substance which is different from a material constituting the sheet-like seal material into the slits and the surface of the seal material.
摘要翻译： 本发明的复合衬垫通过将根据某些片状密封材料的性质选择的密封材料组合在基材中，同时确保密封性能，改善了根据使用条件而不同的各种性能。 复合衬垫通过在片状密封材料的表面上沿着材料的厚度方向延伸的狭缝形成多个狭缝而构成，并且填充由与构成片材的材料不同的物质构成的密封材料 形密封材料进入狭缝和密封材料的表面。
-
5.发明授权Benzylidene compounds, cosmetic compositions containing the same and ultraviolet absorber comprising the same 失效亚苄基化合物，含有它们的化妆品组合物和包含它们的紫外线吸收剂
公开(公告)号：US4985237A
公开(公告)日：1991-01-15
申请号：US259257
申请日：1988-10-18
IPC分类号： A61K8/37 , A61K8/44 , A61K8/49 , A61Q1/02 , A61Q1/06 , A61Q1/12 , A61Q17/04 , C07D233/64 , C07D233/96
CPC分类号： A61Q1/06 , A61K8/37 , A61K8/445 , A61K8/4946 , A61Q1/02 , A61Q1/12 , A61Q17/04 , C07D233/96 , Y10S424/05 , Y10S514/845 , Y10S514/847 , Y10S514/873 , Y10S514/937 , Y10S514/938 , Y10S514/944 , Y10S514/969
摘要： Disclosed herein are benzylidene compounds represented by the formula (I): ##STR1## wherein A represents ##STR2## (wherein B represents hydrogen atom or an acetyl group, W represents hydrogen atom or --CH.sub.2 --CH.sub.2 --CO--O--R, X.sup.1, X.sup.2 and X.sup.3 represent independently hydrogen atom, a hydroxyl group or a methoxyl group (two or three of them may be the same or all of them may be different), Y represents oxygen atom or imino group (--NH--), Z represents a methyl group or a phenyl group, and R represents a straight chain alkyl group having 1 to 18 carbon atoms, or branched or cyclic alkyl group having 3 to 18 carbon atoms, provided that when A is ##STR3## R is not an alkyl group having 1 to 2 carbon atoms, and when A is ##STR4## and X.sup.1, X.sup.2 and X.sup.3 are hydrogen atom, R is not an alkyl group having 1 to 2 carbon atoms), a cosmetic composition containing the same and an ultraviolet absorber comprising the same.
-
公开(公告)号：US5749586A
公开(公告)日：1998-05-12
申请号：US666274
申请日：1996-06-20
申请人： Makoto Abe , Katsuo Wada , Takeshi Miyoshi , Tosiyasu Tanimura , Tetsuya Akai
发明人： Makoto Abe , Katsuo Wada , Takeshi Miyoshi , Tosiyasu Tanimura , Tetsuya Akai
CPC分类号： F16L23/22 , C09K3/1009 , F16J15/104
摘要： A gasket for use in sealing sanitary piping comprises an annular plate of porous polytetrafluoroethylene, the inner surface layer of the gasket being heat treated to form a pore-free fused solidified layer for directly contacting a fluid to be sealed. The fused solidified layer prevents osmotic leakage of sealed fluid. Since the solidified layer is formed only in the surface layer the intrinsic properties of porous polytetrafluoroethylene, such as flexibility and affinity, are retained. The gasket is made by inserting a tubular member with an internal heater into a porous polytetrafluoroethylene gasket so that the tubular member directly contacts the inner surface layer of the gasket. The tubular member is operated at a temperature of 420.degree. to 460.degree. C. and contacts a gasket for 10 to 30 seconds to form the fused and pore-free layer.
摘要翻译： PCT No.PCT / JP95 / 02195 Sec。 371日期：1996年6月20日 102（e）1996年6月20日PCT PCT 1995年10月23日PCT公布。 WO96 / 12903 PCT出版物 日期1996年2月5日用于密封卫生管道的垫圈包括多孔聚四氟乙烯的环形板，将垫圈的内表面层进行热处理以形成用于直接接触被密封流体的无孔熔融凝固层。 熔融凝固层防止密封流体的渗透泄漏。 由于凝固层仅在表面层中形成，所以保留多孔聚四氟乙烯的固有性质，例如柔软性和亲和性。 衬垫通过将具有内部加热器的管状构件插入多孔聚四氟乙烯垫圈中而制成，使得管状构件直接接触垫圈的内表面层。 管状部件在420°至460℃的温度下操作，并与垫圈接触10至30秒以形成熔融和无孔的层。
-
公开(公告)号：US4357434A
公开(公告)日：1982-11-02
申请号：US244111
申请日：1981-03-16
申请人： Takeshi Miyoshi , Koji Takeuchi , Tatsuo Nukui , Hidetaka Oshida
发明人： Takeshi Miyoshi , Koji Takeuchi , Tatsuo Nukui , Hidetaka Oshida
摘要： Stabilized halogen-containing resin compositions comprising a halogen-containing resin, at least one organo tetravelent tin stabilizer selected from the group consisting of an alkyl tin laurate and an alkyl tin maleate and as a stabilizer assistant a hydroxymercaptan compound having the following the general formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are each hydrogen atom, substituted or unsubstituted alkyl, alkenyl, aryl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, carboalkoxyalkyl, epoxyalkyl or epoxyalkenyl, with the proviso R.sub.1 and R.sub.3 may form a ring together.
摘要翻译： 稳定的含卤树脂组合物，其包含含卤树脂，至少一种选自月桂酸烷基锡和马来酸烷基锡的有机四价锡稳定剂，作为稳定剂助剂，具有以下通式的羟基硫醇化合物： 其中R1，R2，R3和R4相同或不同，各自为氢原子，取代或未取代的烷基，烯基，芳基，环烷基，羟基烷基，烷氧基烷基，碳烷氧基烷基，环氧烷基或环氧烯基，条件是R1和R3可以形成 一个环在一起
-
公开(公告)号：US07976028B2
公开(公告)日：2011-07-12
申请号：US11890424
申请日：2007-08-06
IPC分类号： F16J15/12
CPC分类号： F16J15/122
摘要： By improving a metal gasket having a corrugated portion which is advantageous in sealing property, a non-asbestos gasket in which the sealing property is further improved is provided. A non-asbestos gasket has a three-layer structured sealing portion S configured by: a core layer 1A which is made of a plate of a metal, and which is formed into a concentric circle-like corrugated shape; and surface layers 2, 3 which are made of expanded graphite, and which are stacked on the front and back faces of the core layer, respectively. In an outer circumferential end of the sealing portion S, the core layer 1A is protruded from the front and back surface layers 2, 3 toward an outer diameter side. In an inner circumferential end of the sealing portion S, the front and back surface layers 2, 3 are protruded from the core layer 1A toward an inner diameter side, thereby covering the core layer 1A.
摘要翻译： 通过改进具有有利于密封性能的波纹部分的金属垫片，提供了进一步提高密封性能的非石棉垫片。 非石棉垫片具有三层结构的密封部分S，该三层结构密封部分S由以下部分构成：由金属板制成并形成为同心圆状的波纹形状的芯层1A; 以及由膨胀石墨制成并分别堆叠在芯层的前表面和后表面上的表面层2,3。 在密封部S的外周端，芯层1A从前后表面层2,3向外径侧突出。 在密封部S的内周端部，前表面层2,3和后表面层2,3从芯层1A向内径侧突出，从而覆盖芯层1A。
-
公开(公告)号：US20080036161A1
公开(公告)日：2008-02-14
申请号：US11890424
申请日：2007-08-06
IPC分类号： F16J15/10
CPC分类号： F16J15/122
摘要： By improving a metal gasket having a corrugated portion which is advantageous in sealing property, a non-asbestos gasket in which the sealing property is further improved is provided. A non-asbestos gasket has a three-layer structured sealing portion S configured by: a core layer 1A which is made of a plate of a metal, and which is formed into a concentric circle-like corrugated shape; and surface layers 2, 3 which are made of expanded graphite, and which are stacked on the front and back faces of the core layer, respectively. In an outer circumferential end of the sealing portion S, the core layer 1A is protruded from the front and back surface layers 2, 3 toward an outer diameter side. In an inner circumferential end of the sealing portion S, the front and back surface layers 2, 3 are protruded from the core layer 1A toward an inner diameter side, thereby covering the core layer 1A.
摘要翻译： 通过改进具有有利于密封性能的波纹部分的金属垫片，提供了进一步提高密封性能的非石棉垫片。 非石棉垫片具有三层结构密封部分S，该三层结构密封部分S由以下部分构成：芯层1A由金属板制成并形成为同心圆状的波纹形状; 以及由膨胀石墨制成并分别堆叠在芯层的前表面和后表面上的表面层2,3。 在密封部S的外周端，芯层1A从前后表面层2,3向外径侧突出。 在密封部S的内周端部，前表面层2,3和背面层2,3从芯层1A向内径侧突出，从而覆盖芯层1A。
-
公开(公告)号：US5454604A
公开(公告)日：1995-10-03
申请号：US346165
申请日：1994-11-21
CPC分类号： F01N13/1827 , F16J15/125 , Y10S285/91
摘要： A vortex gasket for automotive exhaust system, preferably used with a special flange having a conical seal surface, is formed by spirally overlaying a metal hoop (2) of flat strip, and an inorganic filler (3) of tape form, and annularly spot welding a winding start portion (2a) and a winding end portion (2b) of the hoop (2) to itself. The tape form of the inorganic filler is wider than the flat strip of the metal hoop so that edges of the inorganic filler form seal contact surfaces spaced beyond edges of the metal hoop. When an external force is applied in the axial direction, slipping occurs between the hoop (2) and the filler (3), and the gasket is telescopically deformed in the axial direction, so that the seal contact surfaces 1a, 1b, at sides of the gasket, are formed in a conical shape.
摘要翻译： 用于汽车排气系统的涡流垫片，优选用于具有锥形密封表面的特殊凸缘，通过螺旋地覆盖扁平条的金属箍（2）和带状的无机填料（3）和环形点焊 箍（2）的卷绕起始部分（2a）和卷绕端部（2b）自身。 无机填料的带形式比金属环的扁平条宽，使得无机填料的边缘形成密封接触表面，其间隔超过金属环的边缘。 当沿轴向施加外力时，箍（2）和填料（3）之间发生滑动，并且垫圈在轴向方向可伸缩地变形，使得密封接触表面1a，1b在 垫圈形成为圆锥形。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.028 秒)
