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1.发明申请Gene Marker And Composition For Diagnosis And Treatment Of Neurological Disorders And Diseases And Use Of The Same 审中-公开基因标记和组成用于诊断和治疗神经系统疾病和疾病及其使用公开(公告)号：US20080107600A1
公开(公告)日：2008-05-08
申请号：US10545564
申请日：2004-02-12
申请人： Taiichi Katayama , Takeshi Miyoshi , Masaya Tohyama , Kousuke Baba , Akiko Honda
发明人： Taiichi Katayama , Takeshi Miyoshi , Masaya Tohyama , Kousuke Baba , Akiko Honda
IPC分类号： A61K45/00 , C07K2/00 , C07H21/00 , C07K14/00 , A61P25/18 , A61P25/00 , G01N33/566 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2500/20 , G01N2800/28
摘要： The present invention provides a marker, kit and method for determining the level of axon outgrowth and/or fasciculation, or conditions, disorders or diseases associated with the level of axon outgrowth and/or fasciculation. The present invention was achieved by unexpectedly finding the relationship between DISC1 and FEZ1 and KIAA0844 and unexpectedly finding that axon outgrowth and/or fasciculation are not normally conducted if the normal binding therebetween was inhibited. Therefore, the present invention relates to an agent specifically interacting with DISC1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, an agent specifically binding FEZ1 and a gene product thereof, and an agent specifically binding KIAA0844 and a gene product thereof.
摘要翻译： 本发明提供了一种用于确定与轴突生长和/或束缚水平相关的轴突生长和/或引导或条件，紊乱或疾病的水平的标记物，试剂盒和方法。 本发明通过意外地发现DISC1与FEZ1和KIAA0844的关系而意外地发现，如果其间的正常结合被抑制，则通常不会进行轴突向外生长和/或成像。 因此，本发明涉及与DISC1及其基因产物特异性结合的试剂，特异性结合FEZ1及其基因产物，特异性结合FEZ1及其基因产物的试剂，以及特异性结合KIAA0844和基因的试剂 其产品。
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2.发明申请Method for evaluating a substance capable of effecting on endoplasmic reticulum stress-and/or amyloid beta-induced apoptosis 审中-公开用于评估能够影响内质网应激和/或淀粉样蛋白β诱导凋亡的物质的方法公开(公告)号：US20060024699A1
公开(公告)日：2006-02-02
申请号：US11124103
申请日：2005-05-09
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5041 , G01N2333/96466 , G01N2510/00
摘要： The present invention relates to a method for evaluating a substance capable of affecting endoplasmic reticulum stress-induced apoptosis and/or amyloid-β-induced apoptosis, a kit for evaluating the substance and a pharmaceutical composition.
摘要翻译： 本发明涉及一种评估能够影响内质网应激诱导的凋亡和/或淀粉样蛋白-β诱导的细胞凋亡的物质的方法，用于评价该物质和药物组合物的试剂盒。
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3.发明授权Nucleic acid participating in the formation of presenilin-2-gene exon 5-defective splicing variant 失效核酸参与早老素-2基因外显子5缺陷剪接变体的形成公开(公告)号：US07364847B2
公开(公告)日：2008-04-29
申请号：US10482115
申请日：2002-06-27
CPC分类号： C07K14/4711 , C12Q1/6883 , C12Q2600/156 , G01N33/6896 , G01N2500/00
摘要： The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The present invention relates to a nucleic acid which can be associated with generation of a splice variant that lacks exon 5 of presenilin-2 gene, an inhibitor for inhibiting a binding between protein-nucleic acid caused by aberrant splicing, and a method for screening the inhibitor.
摘要翻译： 本发明提供了治疗和/或预防由异常剪接引起的疾病，由阿尔茨海默病代表的神经变性疾病等的方法。 本发明涉及可以与缺少早老素-2基因的外显子5的剪接变体的产生相关联的核酸，抑制由异常剪接引起的蛋白质 - 核酸之间的结合的抑制剂，以及用于筛选 抑制剂。
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公开(公告)号：US20050065102A1
公开(公告)日：2005-03-24
申请号：US10482103
申请日：2002-06-27
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07H21/02
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4711
摘要： To provide a means useful for treating or preventing a disease such as a brain disorder or a neurodegenerative disease even more efficiently and even more sustainedly. The present invention relates to an inhibitor capable of inhibiting a binding between HMG-I protein and exon 5 of presenilin-2 mRNA, an agent for suppressing neuronal death, capable of suppressing neuronal death, a pharmaceutical composition which is useful for treatment or prevention of a disease caused by the generation of a splice variant that lacks exon 5 of presenilin-2 mRNA, a method for treating or preventing the disease and a use of the inhibitor.
摘要翻译： 提供用于更有效地甚至更持久地治疗或预防诸如脑部疾病或神经变性疾病的疾病的方法。 本发明涉及能够抑制HMG-1蛋白与早老蛋白-2 mRNA的外显子5之间的结合的抑制剂，抑制神经元死亡的能力，能够抑制神经元死亡的药剂组合物，其可用于治疗或预防 由缺乏早老素-2 mRNA的外显子5的剪接变体的产生引起的疾病，治疗或预防疾病的方法和抑制剂的使用。
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