Antibiotic WAP-8294A, method for preparing the same and antibacterial
composition
    4.
    发明授权
    Antibiotic WAP-8294A, method for preparing the same and antibacterial composition 失效
    抗生素WAP-8294A,其制备方法和抗菌组合物

    公开(公告)号:US5648455A

    公开(公告)日:1997-07-15

    申请号:US387322

    申请日:1995-02-13

    CPC分类号: C07K14/195 A61K38/00

    摘要: Antibiotics WAP-8294A, A.sub.1, A.sub.2, A.sub.4, AX, AX-8, AX-9 and AX-13 or pharmeceutically acceptable salts thereof produced by a strain belonging to the genus Lysobacter; a method for producing the foregoing antibiotic WAP-8294A comprising the steps of cultivating, in the culture medium, a microorganism belonging to the genus Lysobacter and having an ability of producing the antibiotic WAP-8294A to produce the antibiotic and accumulate it in the culture medium; then recovering the antibiotic; as well as an antibacterial composition comprising the antibiotic or pharmaceutically acceptable salts thereof are herein disclosed. The novel antibiotic WAP-8294A has an excellent therapeutic effect on infectious diseases developed by infection with Gram-positive bacteria, in particular, MRSA and, therefore, the antibiotic is effective for treating diseases including MRSA infectious diseases developed through infection with Gram-positive bacteria as infectious bacteria.

    摘要翻译: 由属于溶血杆菌属的菌株产生的抗生素WAP-8294A,A1,A2,A4,AX,AX-8,AX-9和AX-13或其药学上可接受的盐; 一种生产上述抗生素WAP-8294A的方法,包括以下步骤:在培养基中培养属于溶血杆菌属的微生物,并具有生产抗生素WAP-8294A以产生抗生素并将其积累在培养基中的能力 ; 然后恢复抗生素; 以及包含抗生素或其药学上可接受的盐的抗菌组合物在本文中公开。 新型抗生素WAP-8294A对感染革兰氏阳性菌特别是MRSA的感染性疾病具有优异的治疗效果,因此抗生素对于治疗包括用革兰氏阳性菌感染而发展的MRSA感染性疾病的疾病是有效的 作为感染性细菌。