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公开(公告)号：US20220340527A1
公开(公告)日：2022-10-27
申请号：US17754118
申请日：2020-09-25
发明人： Yuya OGURO , Makoto KAMATA , Shuhei IKEDA , Takeshi WAKABAYASHI , Norihito TOKUNAGA , Taku KAMEI , Mitsuhiro ITO , Shigemitsu MATSUMOTO , Hirotaka KAMITANI , Takaharu HIRAYAMA , Toshio TANAKA , Hiroshi BANNO , Nobuyuki TAKAKURA , Jinichi YONEMORI , Takuya FUJIMOTO
IPC分类号： C07D211/04 , C07D237/08 , C07D239/26 , C07D405/02
摘要： Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20150315209A1
公开(公告)日：2015-11-05
申请号：US14650429
申请日：2013-12-10
发明人： Tatsuki KOIKE , Yuichi KAJITA , Masato YOSHIKAWA , Shuhei IKEDA , Eiji KIMURA , Tomoaki HASUI , Toshiya NISHI , Hiromi FUKUDA
IPC分类号： C07D498/08 , C07D413/14 , C07D417/14 , C07D403/04 , C07D405/14 , C07D471/10 , C07D401/04 , C07D401/14 , C07D471/08
CPC分类号： C07D498/08 , A61K9/2018 , A61K9/4858 , C07D213/12 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D451/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/08 , C07D491/18 , C12N9/99
摘要： An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明的目的是提供具有优异CH24H抑制作用的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 本发明涉及由下式表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US20240309016A1
公开(公告)日：2024-09-19
申请号：US18606857
申请日：2024-03-15
发明人： Mitsunori KONO , Yusuke SASAKI , Yuya OGURO , Zenichi IKEDA , Osamu KUBO , Masaki SETO , Toru YAMASHITA , Makoto KAMATA , Kenjiro SATO , Matthew Thomas REYNOLDS , Kazuaki TAKAMI , Asato KINA , Takafumi YUKAWA , Minoru NAKAMURA , Taku KAMEI , Hiroyuki KAKEI , Fumie YAMAGUCHI , Tomohiro OHASHI , Keiko KAKEGAWA , Takuto KOJIMA , Florian PÜNNER , Masataka MURAKAMI , Takahiko TANIGUCHI , Tatsuki KOIKE , Yuichi KAJITA , Yuhei MIYANOHANA , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Yasushi HATTORI , Eiji KIMURA , Martin Alexander PAWLICZEK , Marilena PIRA , Shuhei IKEDA , Noriyuki TEZUKA , Yoshikazu WATANABE , Kevin CURRAN , Nicolle DOERING , Maria HOPKINS , Ben JOHNSON , Andre KIRYANOV , Jon LAM , Sean MURPHY , Natasha O'ROURKE , Holly REICHARD , Paul TANIS , Yunlong ZHANG
IPC分类号： C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
CPC分类号： C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20200255439A1
公开(公告)日：2020-08-13
申请号：US16651840
申请日：2018-09-27
发明人： Makoto KAMATA , Hideyuki SUGIYAMA , Minoru NAKAMURA , Masataka MURAKAMI , Shuhei IKEDA , Tomohiro OKAWA , Hidekazu TOKUHARA
IPC分类号： C07D487/10 , A61P25/28 , A61K9/48 , A61K9/20
摘要： The present invention provides a compound having an MAGL inhibitory action, and expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
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公开(公告)号：US20170197983A1
公开(公告)日：2017-07-13
申请号：US15467548
申请日：2017-03-23
发明人： Tatsuki KOIKE , Yuichi KAJITA , Masato YOSHIKAWA , Shuhei IKEDA , Eiji KIMURA , Tomoaki HASUI , Toshiya NISHI , Hiromi FUKUDA
IPC分类号： C07D498/08 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/10 , C07D405/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/14 , C07D487/18
CPC分类号： C07D498/08 , A61K9/2018 , A61K9/4858 , C07D213/12 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D451/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/08 , C07D491/18 , C12N9/99
摘要： An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US20170114042A1
公开(公告)日：2017-04-27
申请号：US15316937
申请日：2015-06-08
发明人： Tatsuki KOIKE , Shuhei IKEDA
IPC分类号： C07D401/14 , C07D417/14 , C07D405/14 , A61K51/04 , C07D401/04
CPC分类号： C07D401/14 , A61K51/0455 , A61K51/0459 , C07B59/002 , C07B2200/05 , C07D401/04 , C07D405/14 , C07D417/14
摘要： The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of CH24H in mammals. The compound of the present invention is represented by the formula (I): wherein each symbol is as defined in the specification.
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公开(公告)号：US20230357220A1
公开(公告)日：2023-11-09
申请号：US17999514
申请日：2021-05-20
发明人： Tomoaki HASUI , Satoshi MIKAMI, JR. , Toru YAMASHITA , Shinji NAKAMURA , Shinji MORIMOTO , Toshihiro IMAEDA , Kazuaki TAKAMI , Masaki DAINI , Hiroyuki KAKEI , Minoru NAKAMURA , Fumie YAMAGUCHI , Chunxiang WANG , Sachie TAKASHIMA , Makoto KAMATA , Yuya OGURO , Shuhei IKEDA
IPC分类号： C07D413/14 , C07D405/14 , C07D401/14
CPC分类号： C07D413/14 , C07D401/14 , C07D405/14
摘要： Abstract: The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer’s disease, schizophrenia, drug addiction, sleep disorders, pain, and attention deficit hyperactivity disorder. Exemplary compounds are e.g. 3-((1H-pyrazol-4-yl)methyl)-6′-(phenyl)-2H-(1,2′-bipyridin)-2-one derivatives and related compounds. The present description discloses the synthesis and characterisation of exemplary compounds, pharmacological data thereof, as well as exemplary tablet formulations comprising the compounds of the invention (e.g. page 83 to page 110; examples 1 to 33; reference example 1; test examples 1 and 2; tables 1 to 4).
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公开(公告)号：US20230150934A1
公开(公告)日：2023-05-18
申请号：US18087233
申请日：2022-12-22
发明人： Shuhei IKEDA , Makoto KAMATA , Yuya OGURO , Jumpei AIDA , Taisuke TAWARAISHI , Takeshi WAKABAYASHI , Norio OYABU , Atsuko OCHIDA , Kouichi IWANAGA , Satoshi YAMAMOTO , Masataka MURAKAMI , Minoru NAKAMURA , Fumie YAMAGUCHI , Takafumi YUKAWA
IPC分类号： C07D207/263 , A61P25/18 , C07D401/06
CPC分类号： C07D207/263 , A61P25/18 , C07D401/06
摘要： A compound of formula (I), or a salt thereof that may have an antagonistic action against an NMDA receptor that includes an NR2B subunit and may be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, a symptom peripheral to dementia, or the like.
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公开(公告)号：US20230002318A1
公开(公告)日：2023-01-05
申请号：US17755907
申请日：2020-11-12
发明人： Shuhei IKEDA , Makoto KAMATA , Yuya OGURO , Jumpei AIDA , Taisuke TAWARAISHI , Takeshi WAKABAYASHI , Norio OYABU , Atsuko OCHIDA , Kouichi IWANAGA , Satoshi YAMAMOTO , Masataka MURAKAMI , Minoru NAKAMURA , Fumie YAMAGUCHI , Takafumi YUKAWA
IPC分类号： C07D207/263 , C07D401/06 , A61P25/18
摘要： A compound of formula (I), or a salt thereof that may have an antagonistic action against an NMDA receptor that includes an NR2B subunit and may be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, a symptom peripheral to dementia, or the like.
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公开(公告)号：US20180079756A1
公开(公告)日：2018-03-22
申请号：US15563161
申请日：2016-03-29
发明人： Shuhei IKEDA , Tatsuki KOIKE , Jumpei AIDA , Makoto FUSHIMI , Tomokazu KUSUMOTO , Hideyuki SUGIYAMA , Masako MIYAZAKI , Hidekazu TOKUHARA , Yasushi HATTORI , Makoto KAMATA
IPC分类号： C07D498/04 , C07D401/10 , C07D413/10 , C07D413/14 , C07D417/14
CPC分类号： C07D498/04 , A61K31/454 , A61K31/4709 , A61K31/538 , A61K31/5383 , C07D401/06 , C07D401/10 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C12N9/99
摘要： The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.The present invention relates a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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