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1.发明申请公开(公告)号：US20100196384A1
公开(公告)日：2010-08-05
申请号：US12762649
申请日：2010-04-19
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
IPC分类号： A61K39/395 , C07K16/18 , C12N5/07 , G01N33/53 , A61P37/06
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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2.发明授权Anti-histone H1 monoclonal antibody and hybridoma for the production thereof 有权抗组蛋白H1单克隆抗体和用于其生产的杂交瘤公开(公告)号：US08187602B2
公开(公告)日：2012-05-29
申请号：US12762649
申请日：2010-04-19
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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公开(公告)号：US07964554B2
公开(公告)日：2011-06-21
申请号：US11661763
申请日：2005-09-05
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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4.发明申请公开(公告)号：US20080287352A1
公开(公告)日：2008-11-20
申请号：US11661763
申请日：2005-09-05
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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公开(公告)号：US07888123B2
公开(公告)日：2011-02-15
申请号：US11413173
申请日：2006-04-28
申请人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
发明人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
摘要： An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design and development of novel functional lipid molecules by the control of the mechanisms. The present invention provides a method for introducing a transgene into a cell of Labyrinthulomycota, which comprises introducing into a cell of Labyrinthulomycota a recombinant vector comprising a transgene and a nucleotide sequence which is homologous to a part of chromosomal DNA of Labyrinthulomycota and is capable of homologous recombination with the chromosomal DNA, and then inducing homologous recombination in this homologous nucleotide sequence.
摘要翻译： 本发明的一个目的是提供一种能够阐明脂质如PUFA和类胡萝卜素的生物合成机理的Labyrinthuloycycota的转化系统，以及构建高生产系统以及新型功能性脂质分子的设计和开发 机制的控制。 本发明提供了将转基因导入到迷路神经霉素细胞中的方法，其包括将包含转基因和核苷酸序列的重组载体导入到迷路形霉菌属细胞中，该载体与Labyrinthuloycycota的一部分染色体DNA同源且能够同源 与染色体DNA重组，然后在该同源核苷酸序列中诱导同源重组。
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公开(公告)号：US20060286650A1
公开(公告)日：2006-12-21
申请号：US11413141
申请日：2006-04-28
申请人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
发明人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
CPC分类号： C12P7/6463 , C12N15/79 , C12P7/6409
摘要： An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design and development of novel functional lipid molecules by the control of the mechanisms. The present invention provides a vector for the transformation of Labyrinthulomycota with a transgene, which comprises at least (1) a nucleotide sequence which is homologous to a part of chromosomal DNA of Labyrinthulomycota and is capable of homologous recombination with the chromosomal DNA, (2) a selection marker gene having a promoter sequence located upstream and a terminator sequence located downstream, and (3) a cloning site for transgene insertion having a promoter sequence located upstream and a terminator sequence located downstream.
摘要翻译： 本发明的一个目的是提供一种能够阐明脂质如PUFA和类胡萝卜素的生物合成机理的Labyrinthuloycycota的转化系统，以及构建高生产系统以及新型功能性脂质分子的设计和开发 机制的控制。 本发明提供了用转基因转化迷路孢霉菌纲的载体，其包含至少（1）与Labyrinthuloycycota的一部分染色体DNA同源且能够与染色体DNA同源重组的核苷酸序列，（2） 具有位于上游的启动子序列和位于下游的终止子序列的选择标记基因，和（3）位于上游的位于上游的启动子序列和位于下游的终止子序列的转基因插入的克隆位点。
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公开(公告)号：US20060275904A1
公开(公告)日：2006-12-07
申请号：US11413173
申请日：2006-04-28
申请人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
发明人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
摘要： An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design and development of novel functional lipid molecules by the control of the mechanisms. The present invention provides a method for introducing a transgene into a cell of Labyrinthulomycota, which comprises introducing into a cell of Labyrinthulomycota a recombinant vector comprising a transgene and a nucleotide sequence which is homologous to a part of chromosomal DNA of Labyrinthulomycota and is capable of homologous recombination with the chromosomal DNA, and then inducing homologous recombination in this homologous nucleotide sequence.
摘要翻译： 本发明的一个目的是提供一种能够阐明脂质如PUFA和类胡萝卜素的生物合成机理的Labyrinthuloycycota的转化系统，以及构建高生产系统以及新型功能性脂质分子的设计和开发 机制的控制。 本发明提供了将转基因导入到迷路神经霉素细胞中的方法，其包括将包含转基因和核苷酸序列的重组载体导入到迷路形霉菌属细胞中，该载体与Labyrinthuloycycota的一部分染色体DNA同源且能够同源 与染色体DNA重组，然后在该同源核苷酸序列中诱导同源重组。
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公开(公告)号：US07759097B2
公开(公告)日：2010-07-20
申请号：US11413141
申请日：2006-04-28
申请人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
发明人： Kazuhisa Ono , Tsunehiro Aki , Seiji Kawamoto
CPC分类号： C12P7/6463 , C12N15/79 , C12P7/6409
摘要： An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design and development of novel functional lipid molecules by the control of the mechanisms. The present invention provides a vector for the transformation of Labyrinthulomycota with a transgene, which comprises at least (1) a nucleotide sequence which is homologous to a part of chromosomal DNA of Labyrinthulomycota and is capable of homologous recombination with the chromosomal DNA, (2) a selection marker gene having a promoter sequence located upstream and a terminator sequence located downstream, and (3) a cloning site for transgene insertion having a promoter sequence located upstream and a terminator sequence located downstream.
摘要翻译： 本发明的一个目的是提供一种能够阐明脂质如PUFA和类胡萝卜素的生物合成机理的Labyrinthuloycycota的转化系统，以及构建高生产系统以及新型功能性脂质分子的设计和开发 机制的控制。 本发明提供了用转基因转化迷路孢霉菌纲的载体，其包含至少（1）与Labyrinthuloycycota的一部分染色体DNA同源且能够与染色体DNA同源重组的核苷酸序列，（2） 具有位于上游的启动子序列和位于下游的终止子序列的选择标记基因，和（3）位于上游的位于上游的启动子序列和位于下游的终止子序列的转基因插入的克隆位点。
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公开(公告)号：US4818525A
公开(公告)日：1989-04-04
申请号：US81471
申请日：1987-08-04
CPC分类号： A01N25/10 , A01N25/18 , A01N25/24 , Y10S424/10 , Y10S424/11
摘要： An insecticidal resin coating film comprising a combination of an acrylonitrile and/or methacrylonitrile copolymer resin and an insecticidal component selected from the group consisting of specified compounds exhibits an insecticidal effect, since the compound is kept on the surface of the coating film in a state capable of exhibiting its insecticidal effect for a long period of time.
摘要翻译： 包含丙烯腈和/或甲基丙烯腈共聚物树脂和选自特定化合物的杀虫成分的组合的杀虫树脂涂膜具有杀虫效果，因为化合物以能够保持的状态保持在涂膜的表面上 长期展现其杀虫作用。
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公开(公告)号：US06001444A
公开(公告)日：1999-12-14
申请号：US989643
申请日：1997-12-12
申请人： Akihiro Koide , Satoru Suda , Hideo Usui , Kenichi Arai , Yuuichi Ito , Taisaku Kano , Seiji Kawamoto
发明人： Akihiro Koide , Satoru Suda , Hideo Usui , Kenichi Arai , Yuuichi Ito , Taisaku Kano , Seiji Kawamoto
IPC分类号： B41M1/30 , B41M3/00 , B41M5/52 , B41M7/00 , C08F220/28 , C09D4/00 , C09D11/10 , G11B7/252 , G11B7/253 , G11B7/2534 , G11B7/254 , G11B7/2542 , G11B7/257 , G11B7/258 , G11B7/2595 , G11B23/40 , B32B3/00
CPC分类号： G11B7/257 , B41M3/003 , B41M7/0027 , B41M7/0081 , C09D11/101 , C09D4/00 , G11B7/252 , G11B7/2542 , C08F2220/283 , G11B23/40 , G11B7/248 , G11B7/2534 , G11B7/2595 , Y10S428/913 , Y10S430/146 , Y10T428/21 , Y10T428/31678
摘要： Provided is an optical recording medium comprising at least a recording layer, a metal reflective layer, a protective layer and a printing layer laminated on a transparent substrate, wherein the printing layer is obtained by curing a UV-curing ink composition and said ink composition contains a compound which has a solubility parameter falling in the range of 7 to 10 and which takes no part in UV curing and does not react with other components contained therein.
摘要翻译： 提供了一种至少包括记录层，金属反射层，保护层和层叠在透明基板上的印刷层的光学记录介质，其中通过固化UV固化油墨组合物获得印刷层，并且所述油墨组合物含有 溶解度参数在7〜10范围内的化合物，其不参与UV固化，并且不与其中所含的其它组分反应。
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