公开(公告)号：US4943681A

公开(公告)日：1990-07-24

申请号：US454953

申请日：1989-12-22

申请人： Takeshi Sato ,  Shuji Miyazaki ,  Makoto Sakamoto ,  Motonori Ando

发明人： Takeshi Sato ,  Shuji Miyazaki ,  Makoto Sakamoto ,  Motonori Ando

IPC分类号： G11B7/248

CPC分类号： G11B7/248 ,  Y10S430/146

摘要： An optical recording medium which comprises an organic thin film layer containing at least one of phthalocyanine compounds, due to which high light absorptivity to laser beams and high recording sensitivity can be obtained. The optical recording medium provided by the present invention has high chemical and physical stability. There is also disclosed a process for the production of the optical recording medium.

摘要翻译： 可以获得包含含有至少一种酞菁化合物的有机薄膜层的光学记录介质，由此可以获得对激光束的高的光吸收率和高的记录灵敏度。 本发明提供的光记录介质具有高的化学和物理稳定性。 还公开了一种用于生产光学记录介质的方法。

公开(公告)号：US08946437B2

公开(公告)日：2015-02-03

申请号：US13877276

申请日：2011-10-03

申请人： Takashi Nakagawa ,  Makoto Sakamoto ,  Kazuya Yamaguchi ,  Yuki Terauchi ,  Masamichi Shirakura ,  Yasuo Harada ,  Yutaka Kojima ,  Takumi Sumida

发明人： Takashi Nakagawa ,  Makoto Sakamoto ,  Kazuya Yamaguchi ,  Yuki Terauchi ,  Masamichi Shirakura ,  Yasuo Harada ,  Yutaka Kojima ,  Takumi Sumida

IPC分类号： A01N43/40 ,  A61K31/44 ,  C07D211/72 ,  C07D211/84 ,  C07D213/63 ,  C07D213/70 ,  C07D213/72 ,  C07D213/78 ,  C07D213/76 ,  C07D213/75

CPC分类号： C07D213/75 ,  C07D213/76

摘要： The present invention provides a novel compound having an excellent antitumor effect, stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.

摘要翻译： 本发明提供具有优异的抗肿瘤效果，稳定性和代谢稳定性的新型化合物。 本发明化合物由以下通式（1）表示，其中R 1表示卤素原子，芳基，芳氧基或任选被一个或多个卤素原子取代的低级烷基; R2表示氢原子，卤素原子，低级烷基或低级烷氧基; 和; m表示1〜3的整数， 条件是当m表示2或3时，R 1相同或不同。

公开(公告)号：US08638091B2

公开(公告)日：2014-01-28

申请号：US13286429

申请日：2011-11-01

申请人： Takashi Hibino ,  Takashi Fujimoto ,  Shigeki Namekata ,  Keisuke Komatsu ,  Yoshiyuki Nakao ,  Makoto Takata ,  Makoto Sakamoto

发明人： Takashi Hibino ,  Takashi Fujimoto ,  Shigeki Namekata ,  Keisuke Komatsu ,  Yoshiyuki Nakao ,  Makoto Takata ,  Makoto Sakamoto

IPC分类号： G01N27/90

CPC分类号： G01N27/902 ,  G01N27/904

摘要： A rotary eddy current flaw detection probe device has a plurality of Θ-shaped eddy current flaw detection probes attached in a rotating disc for detecting flaws in all directions regardless of the flaw direction. Four Θ-shaped eddy current testing probes P11 to P22 are arranged around the rotation center Ds1 of a rotating disc 111 and are embedded in the disc 111. The coil planes of detector coils Ds11 to Ds22 of the testing probes P11 to P22 are parallel with each other, and are perpendicular to the rotation plane of the rotating disc 111. The coil planes of the detector coils incline at an angle θ relative to a line Y passing through the centers Ps11 and Ps12 of the probes P11 and P12. The detector coils Dc11 and Dc12 are cumulatively connected to each other and the detector coils Dc21 and Dc22 are differentially connected to each other.

摘要翻译： 旋转涡流探伤探针装置具有附接在旋转盘中的多个Theta形涡流探伤探针，用于检测各个方向的瑕疵，而不管瑕疵方向如何。 四个Theta形涡电流测试探针P11至P22围绕旋转盘111的旋转中心Ds1布置并嵌入到盘111中。测试探针P11至P22的检测器线圈Ds11至Ds22的线圈平面与 彼此垂直于旋转盘111的旋转平面。检测器线圈的线圈面相对于穿过探针P11和P12的中心Ps11和Ps12的线Y以一定角度倾斜。 检测器线圈Dc11和Dc12彼此累积连接，检测线圈Dc21和Dc22彼此差分地连接。

公开(公告)号：US08551999B2

公开(公告)日：2013-10-08

申请号：US12740684

申请日：2008-10-29

申请人： Takumi Sumida ,  Fujio Tabusa ,  Kazuo Sekiguchi ,  Takeshi Kodama ,  Koichi Yasumura ,  Yutaka Kojima ,  Masaaki Motoyama ,  Keisuke Miyajima ,  Kenji Yoshida ,  Keizo Kan ,  Makoto Sakamoto ,  Hideki Takasu ,  Takashi Nakagawa ,  Naoto Ohi ,  Yasuo Harada ,  Norikazu Hashimoto ,  Hironori Matsuyama ,  Masatoshi Iida ,  Shigekazu Fujita ,  Tae Fukushima

发明人： Takumi Sumida ,  Fujio Tabusa ,  Kazuo Sekiguchi ,  Takeshi Kodama ,  Koichi Yasumura ,  Yutaka Kojima ,  Masaaki Motoyama ,  Keisuke Miyajima ,  Kenji Yoshida ,  Keizo Kan ,  Makoto Sakamoto ,  Hideki Takasu ,  Takashi Nakagawa ,  Naoto Ohi ,  Yasuo Harada ,  Norikazu Hashimoto ,  Hironori Matsuyama ,  Masatoshi Iida ,  Shigekazu Fujita ,  Tae Fukushima

IPC分类号： A61K31/496 ,  A61K31/454 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  A61K31/506 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D403/12

摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

摘要翻译： 本发明提供由通式（1）表示的杂环化合物：其中R1为R5-Z1-基团等，Z1为低级亚烷基等，R5为通式所示的基团。 其中R 13为氢原子等，m为1至5的整数; R2是氢原子：Y是CH或N：A1是选自吲哚二基的杂环，其中杂环可以具有至少一个取代基：T是-CO-等：R3是 氢原子等：R4是任选被一个或多个羟基取代的低级烷基等：R 3和R 4与它们所键合的氮原子一起可以彼此结合形成5- 10元饱和杂环，其中杂环可以具有至少一个取代基。 本发明的杂环化合物具有抑制胶原蛋白的生成和/或治疗肿瘤的优异效果。

公开(公告)号：US20120161758A1

公开(公告)日：2012-06-28

申请号：US13140845

申请日：2009-12-14

申请人： Takashi Hibino ,  Takashi Fujimoto ,  Keisuke Komatsu ,  Yoshiyuki Nakao ,  Makoto Takata ,  Makoto Sakamoto

发明人： Takashi Hibino ,  Takashi Fujimoto ,  Keisuke Komatsu ,  Yoshiyuki Nakao ,  Makoto Takata ,  Makoto Sakamoto

IPC分类号： G01R33/12

CPC分类号： G01N27/902 ,  G01N27/82

摘要： In an eddy current testing method which involves using a rotatable eddy current testing probe in which a detection coil is arranged within an exciting coil, a change in detection sensitivity (a deviation of detection sensitivity) which changes depending on the rotational position of the detection coil is reduced. The eddy current testing probe includes an exciting coil EC1, a detection coil DC1, an exciting coil EC2 and a detection coil DC2, which are mounted on a disk DS. The eddy current testing probe is placed so as to face a circumferential surface of an object to be inspected T, which is in the shape of a circular cylinder, and the disk DS is rotated. Then, the distance (liftoff) between the detection coils DC1 and DC2 and an inspection surface changes. Therefore, also the detection sensitivity to a flaw signal changes. To reduce the change in detection sensitivity, the detection sensitivity is adjusted by detecting the rotational position (rotational angle) of the detection coils DC1 and DC2.

摘要翻译： 在涡电流测试方法中，涉及使用其中检测线圈布置在励磁线圈内的可旋转涡流测试探针，检测灵敏度的变化（检测灵敏度的偏差）根据检测线圈的旋转位置而变化 降低了。 涡电流测试探头包括安装在盘DS上的励磁线圈EC1，检测线圈DC1，励磁线圈EC2和检测线圈DC2。 将涡电流测试探针放置成面对被检查物体T的圆周表面，该圆形表面呈圆柱形，圆盘DS旋转。 然后，检测线圈DC1和DC2之间的距离（剥离）和检查面发生变化。 因此，对缺陷信号的检测灵敏度也会发生变化。 为了减小检测灵敏度的变化，通过检测检测线圈DC1和DC2的旋转位置（旋转角度）来调节检测灵敏度。

公开(公告)号：US5003200A

公开(公告)日：1991-03-26

申请号：US408523

申请日：1989-09-18

申请人： Makoto Sakamoto

发明人： Makoto Sakamoto

IPC分类号： H03K19/177

CPC分类号： H03K19/17736 ,  H03K19/17704

摘要： There is provided a programmable logic device (PLD) which includes a programmable wiring, the programmable wiring comprising: a plurality of switch stations (SS), first wirings each for directly connecting some terminals among input/output terminals of said SSs to input/output terminals of adjacent programmable logic elements (PLE), and second wirings each for directly connecting some terminals among the input/output terminals of said SSs to input/output terminals of the adjacent SS. Hereby, the numbers of involved switches, through which associated signals pass, can be reduced.

公开(公告)号：US08687850B2

公开(公告)日：2014-04-01

申请号：US13469720

申请日：2012-05-11

申请人： Takeo Nakata ,  Masami Ikeda ,  Makoto Sakamoto ,  Kenji Fujiwara ,  Kazuhiro Uchida

发明人： Takeo Nakata ,  Masami Ikeda ,  Makoto Sakamoto ,  Kenji Fujiwara ,  Kazuhiro Uchida

IPC分类号： G06K9/00

CPC分类号： G01N21/70 ,  G01N19/06 ,  G01N21/71 ,  G01N33/20

摘要： An apparatus 1 for determining a kind of a steel material detects a spark pixel from a color picked-up image 2 of a spark 19 produced when a steel material 18 is ground, and detects a pixel, in which the density of any one color component for judgment selected from among RGB color components is low, as a low-density pixel from the spark pixels. The apparatus 1 determines that the steel material is a steel material consisting of the high-strength steel if the ratio of the total number of low-density pixels to the total number of spark pixels is not lower than a threshold value for judgment, and determines that the steel material is a steel material consisting of the ordinary steel if the ratio is lower than the threshold value for judgment.

摘要翻译： 用于确定钢材种类的装置1从钢材18被研磨时产生的火花19的彩色拍摄图像2中检测火花像素，并且检测其中任何一种颜色分量的密度 从RGB颜色分量中选择的判断较低，作为来自火花像素的低密度像素。 如果低密度像素总数与火花像素总数的比例不低于用于判断的阈值，则钢材是由高强度钢构成的钢材，并且确定 如果该比率低于用于判断的阈值，则该钢材是由普通钢组成的钢材。

公开(公告)号：US20100004438A1

公开(公告)日：2010-01-07

申请号：US12095930

申请日：2006-12-04

申请人： Hironori Matsuyama ,  Kenji Ohnishi ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Kumi Higuchi ,  Keisuke Miyajima ,  Satoshi Yamada ,  Masaaki Motoyama ,  Yutaka Kojima ,  Koichi Yasumura ,  Takeshi Kodama ,  Shun Otsuji ,  Keizo Kan ,  Takumi Sumida

发明人： Hironori Matsuyama ,  Kenji Ohnishi ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Kumi Higuchi ,  Keisuke Miyajima ,  Satoshi Yamada ,  Masaaki Motoyama ,  Yutaka Kojima ,  Koichi Yasumura ,  Takeshi Kodama ,  Shun Otsuji ,  Keizo Kan ,  Takumi Sumida

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D295/155 ,  C07D211/56 ,  C07D213/72

CPC分类号： A61K31/496 ,  A61K31/495

摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group -Z-R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明的目的在于提供一种抗肿瘤活性大大提高的安全性药物。 根据本发明，提供含有下述通式（1）表示的化合物或其盐作为有效成分的药物：[式1]其中X1表示氮原子或基团-CH-， R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，二环或三环饱和或不饱和杂环基 具有1至4个氮原子，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基 A表示[式2]其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US20060002407A1

公开(公告)日：2006-01-05

申请号：US11023151

申请日：2004-12-27

申请人： Makoto Sakamoto

发明人： Makoto Sakamoto

IPC分类号： H04L12/28 ,  H04L12/56

CPC分类号： H04L61/2015 ,  H04L12/462 ,  H04L29/12018 ,  H04L29/12584 ,  H04L29/1282 ,  H04L29/12839 ,  H04L41/00 ,  H04L41/08 ,  H04L61/10 ,  H04L61/2596 ,  H04L61/6013 ,  H04L61/6022

摘要： A network system according to the present invention includes a plurality of local area networks (LANs); a wide area network (WAN); a plurality of network bridge devices (CPEs) that connect the LANs to the WAN; and a network management apparatus (OSP) that is connected to the WAN and centrally controls the entire network. The LANs and the WAN both comply with the IEEE 802.3 standard. When receiving a MAC broadcast frame (such as DHCP request and ARP request) from the LANs, the CPEs convert it into a MAC unicast frame, and unicast it to the OSP. As a result, bandwidth saturation of the network due to the explosion or concentration of traffic is prevented.

摘要翻译： 根据本发明的网络系统包括多个局域网（LAN）; 广域网（WAN）; 将LAN连接到WAN的多个网桥装置（CPE）; 以及连接到WAN并集中控制整个网络的网络管理装置（OSP）。 LAN和WAN都符合IEEE 802.3标准。 当从LAN接收到MAC广播帧（如DHCP请求和ARP请求）时，CPE将其转换为MAC单播帧，并将其单播到OSP。 结果，由于业务的爆炸或集中而导致的网络的带宽饱和度被阻止。

公开(公告)号：US5082770A

公开(公告)日：1992-01-21

申请号：US176885

申请日：1988-04-04

申请人： Masato Okada ,  Makoto Sakamoto

发明人： Masato Okada ,  Makoto Sakamoto

IPC分类号： C12N9/02 ,  C12Q1/26 ,  C12Q1/32

CPC分类号： C12N9/0008 ,  C12Q1/26 ,  C12Q1/32 ,  C12Y102/01019 ,  Y10S435/859

摘要： A method for the quantitative determination of polyamines, which comprises allowing a polyamine oxidizing enzyme, an .omega.-aminoalkylaldehyde dehydrogenase, an oxidized nicotinamide coenzyme and, as required, an acylpolyamine anidohydrolase to act upon a sample solution containing polyamines (for example, urine, blood and other kinds of body fluid), and measuring the reduced nicotinamide coenzyme thus formed by, for example, colorimetry, thereby determining the amount of said polyamines.

摘要翻译： 一种用于多胺定量测定的方法，其包括使多胺氧化酶，ω-氨基烷基醛脱氢酶，氧化烟酰胺辅酶和根据需要的酰基聚胺酰胺水解酶作用于含有多胺（例如尿，血液）的样品溶液 和其他种类的体液），并且通过例如比色法测量由此形成的还原型烟酰胺辅酶，从而确定所述多胺的量。