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公开(公告)号:US08329843B2
公开(公告)日:2012-12-11
申请号:US13197066
申请日:2011-08-03
申请人: Hiroko Shibamoto , Toshikazu Aikawa , Teruo Arii , Masanori Muramoto , Takeshi Fukuda , Kiyoshi Ito , Takeya Abe , Souichi Hazama
发明人: Hiroko Shibamoto , Toshikazu Aikawa , Teruo Arii , Masanori Muramoto , Takeshi Fukuda , Kiyoshi Ito , Takeya Abe , Souichi Hazama
CPC分类号: C12P13/00 , C07C231/06 , C08F220/56 , C12P13/02 , C07C233/09
摘要: A method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity wherein the concentration of benzene in the aqueous medium is 4.0 ppm or less and a method for producing an amide-based polymer excellent in quality from the amide compound. Also provided are a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between water solubility and high molecular weight and is excellent in quality.
摘要翻译: 在具有腈水合酶活性的催化剂存在下,在含水介质中由腈化合物制备酰胺化合物的方法,其中水介质中苯的浓度为4.0ppm或更低,以及制备酰胺基聚合物的方法 优异的酰胺化合物。 还提供了通过含有腈水合酶等的微生物催化剂更有效地制备具有更高质量的丙烯酰胺的方法和色调优异的丙烯酰胺类聚合物的制造方法,水溶性与 高分子量,质量优良。
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公开(公告)号:US20090311759A1
公开(公告)日:2009-12-17
申请号:US12301138
申请日:2007-04-03
申请人: Takeya Abe , Takeshi Fukuda
发明人: Takeya Abe , Takeshi Fukuda
IPC分类号: C12P13/02
CPC分类号: C07C231/24 , C12P13/02 , C07C233/09
摘要: [Problem] To provide a process for producing (meth)acrylamide using a microbial catalyst, wherein production steps can be simplified and production cost can be reduced.[Means for solving problem] The process for producing (meth)acrylamide of the present invention is a process comprising (a) a step of allowing (meth)acrylonitrile to undergo hydration reaction by the use of a microbial catalyst containing nitrile hydratase in an aqueous medium to obtain a (meth)acrylamide reaction solution (I) and (b) a step of removing impurities from the reaction solution (I) to obtain a (meth)acrylamide aqueous solution (II), wherein the concentration of (meth)acrylamide in the reaction solution (I) obtained in the step (a) is higher than the concentration of (meth)acrylamide in the aqueous solution (II) obtained in the step (b) by 2 to 20% by weight.
摘要翻译: [问题]提供使用微生物催化剂制备(甲基)丙烯酰胺的方法,其中可以简化生产步骤并降低生产成本。 [解决问题的方法]本发明的(甲基)丙烯酰胺的制造方法是一种方法,其包括(a)使(甲基)丙烯腈进行水合反应的工序,其中使用含腈水合酶的微生物催化剂 培养以得到(甲基)丙烯酰胺反应溶液(I)和(b)从反应溶液(I)中除去杂质以获得(甲基)丙烯酰胺水溶液(II)的步骤,其中(甲基)丙烯酰胺 在步骤(a)中获得的反应溶液(I)中,比步骤(b)中获得的水溶液(II)中的(甲基)丙烯酰胺的浓度高2至20重量%。
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公开(公告)号:US20090171051A1
公开(公告)日:2009-07-02
申请号:US12089511
申请日:2006-10-06
申请人: Hiroko Shibamoto , Toshikazu Aikawa , Teruo Arii , Masanori Muramoto , Takeshi Fukuda , Kiyoshi Ito , Takeya Abe , Souichi Hazama
发明人: Hiroko Shibamoto , Toshikazu Aikawa , Teruo Arii , Masanori Muramoto , Takeshi Fukuda , Kiyoshi Ito , Takeya Abe , Souichi Hazama
CPC分类号: C12P13/00 , C07C231/06 , C08F220/56 , C12P13/02 , C07C233/09
摘要: [Problems] The present invention provides a method for efficiently producing a corresponding amide compound from a nitrile compound by a reaction using a nitrile hydratase and a method for producing an amide-based polymer excellent in quality from the amide compound. In addition, the present invention provides a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between the water solubility and the high molecular weight and is also excellent in quality, by using the acrylamide.[Means for Solving the Problems] The method for producing an amide compound of the present invention is characterized in that in a method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity, the concentration of benzene in the aqueous medium is 4.0 ppm or less. In addition, the method for producing an amide-based polymer of the present invention is characterized by homopolymerizing the amide compound or by copolymerizing the amide compound and at least unsaturated monomer copolymerizable with the amide compound. Further, the method for producing acrylamide of the present invention is characterized by hydrating acrylonitrile having a concentration of acrolein of 1 ppm or less by a microbial cell containing a nitrile hydratase or a processed product of the microbial cell in an aqueous medium. Furthermore, the method for producing an acrylamide-based polymer of the present invention is characterized by homopolymerizing the acrylamide or by copolymerizing the acrylamide and at least one unsaturated monomer copolymerizable with the acrylamide.
摘要翻译: 本发明提供一种通过使用腈水合酶的反应从腈化合物有效地制备相应的酰胺化合物的方法和由酰胺化合物质量优异的酰胺类聚合物的制备方法。 此外,本发明提供了一种通过含有腈水合酶等的微生物催化剂更有效地制备丙烯酰胺的方法以及色调优异的丙烯酰胺类聚合物的制造方法,其平衡性良好 在水溶性和高分子量之间,并且通过使用丙烯酰胺也具有优异的质量。 解决问题的手段本发明的酰胺化合物的制造方法的特征在于,在具有腈水合酶活性的催化剂存在下,在含水介质中由腈化合物制备酰胺化合物的方法中, 水介质中苯的浓度为4.0ppm以下。 此外,本发明的酰胺系聚合物的制造方法的特征在于,使酰胺化合物均聚,或者使酰胺化合物与至少与酰胺化合物可共聚的不饱和单体共聚。 此外,本发明的丙烯酰胺的制造方法的特征在于,通过含有腈水合酶的微生物细胞或微生物细胞的加工产物在水性介质中使丙烯醛浓度为1ppm以下的丙烯腈水合。 此外,本发明的丙烯酰胺类聚合物的制造方法的特征在于使丙烯酰胺均聚或通过共聚丙烯酰胺和至少一种与丙烯酰胺共聚的不饱和单体。
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公开(公告)号:US08143033B2
公开(公告)日:2012-03-27
申请号:US12301138
申请日:2007-04-03
申请人: Takeya Abe , Takeshi Fukuda
发明人: Takeya Abe , Takeshi Fukuda
IPC分类号: C12P13/02
CPC分类号: C07C231/24 , C12P13/02 , C07C233/09
摘要: A process for producing (meth)acrylamide using a microbial catalyst, wherein production steps can be simplified and production cost can be reduced. The process for producing (meth)acrylamide of the present involves (a) a step of allowing (meth)acrylonitrile to undergo hydration reaction by the use of a microbial catalyst containing nitrile hydratase in an aqueous medium to obtain a (meth)acrylamide reaction solution (I) and (b) a step of removing impurities from the reaction solution (I) to obtain a (meth)acrylamide aqueous solution (II), wherein the concentration of (meth)acrylamide in the reaction solution (I) obtained in the step (a) is higher than the concentration of (meth)acrylamide in the aqueous solution (II) obtained in the step (b) by 2 to 20% by weight.
摘要翻译: 使用微生物催化剂制造(甲基)丙烯酰胺的方法,其中可以简化生产步骤并降低生产成本。 本发明的(甲基)丙烯酰胺的制造方法包括:(a)使含有腈水合酶的微生物催化剂在水性介质中进行水合反应的步骤,得到(甲基)丙烯酰胺反应液 (I)和(b)从反应溶液(I)中除去杂质以获得(甲基)丙烯酰胺水溶液(II)的步骤,其中在(I)中获得的反应溶液(I)中的(甲基)丙烯酰胺的浓度 步骤(a)比步骤(b)中得到的水溶液(II)中的(甲基)丙烯酰胺的浓度高2〜20重量%。
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公开(公告)号:US20110288255A1
公开(公告)日:2011-11-24
申请号:US13197066
申请日:2011-08-03
申请人: Hiroko Shibamoto , Toshikazu Aikawa , Teruo Arii , Masanori Muramoto , Takeshi Fukuda , Kiyoshi Ito , Takeya Abe , Souichi Hazama
发明人: Hiroko Shibamoto , Toshikazu Aikawa , Teruo Arii , Masanori Muramoto , Takeshi Fukuda , Kiyoshi Ito , Takeya Abe , Souichi Hazama
CPC分类号: C12P13/00 , C07C231/06 , C08F220/56 , C12P13/02 , C07C233/09
摘要: A method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity wherein the concentration of benzene in the aqueous medium is 4.0 ppm or less and a method for producing an amide-based polymer excellent in quality from the amide compound. Also provided are a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between water solubility and high molecular weight and is excellent in quality.
摘要翻译: 在具有腈水合酶活性的催化剂存在下,在含水介质中由腈化合物制备酰胺化合物的方法,其中水介质中苯的浓度为4.0ppm或更低,以及制备酰胺基聚合物的方法 优异的酰胺化合物。 还提供了通过含有腈水合酶等的微生物催化剂更有效地制备具有更高质量的丙烯酰胺的方法和色调优异的丙烯酰胺类聚合物的制造方法,水溶性与 高分子量,质量优良。
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公开(公告)号:US07002041B2
公开(公告)日:2006-02-21
申请号:US10286826
申请日:2002-11-04
申请人: Takeya Abe , Kenju Sasaki
发明人: Takeya Abe , Kenju Sasaki
IPC分类号: C07C209/90
CPC分类号: C07C231/22 , C07C233/09
摘要: An amide composition containing an unsaturated amide, a sulfur-containing compound, and a weak acid salt. The composition can include an amide in crystalline form or the composition can be in form of aqueous solution. The composition can exhibit improved stability whereby polymerization of the amide is inhibited.
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公开(公告)号:US6063893A
公开(公告)日:2000-05-16
申请号:US84194
申请日:1998-05-26
申请人: Minato Karasawa , Takeya Abe , Takuji Shimizu , Takeshi Iwaki
发明人: Minato Karasawa , Takeya Abe , Takuji Shimizu , Takeshi Iwaki
IPC分类号: C07C233/35 , C07C233/36 , C07C251/02 , C07C251/08 , C08G18/12 , C08G59/40 , C08G59/44 , C08G59/68 , C08G65/10 , C08L63/00
CPC分类号: C08G59/44 , C07C233/35 , C07C233/36 , C07C251/02 , C07C251/08 , C08G18/12 , C08G59/4042 , C08L63/00
摘要: A curing agent having less odor and providing a cured resin which is excellent in appearance, mechanical properties, water resistance and chemical resistance, and a one-component type humidity-curing resin composition having excellent storage stability and providing a cured matter which is excellent in appearance and physical properties. Specifically, provided are polyaminoamide or ketimine obtained by dehydration of 2,5- and/or 2,6-bis(aminomethyl)-bicyclo[2.2.1]heptane with carboxylic acids or ketones, a curing agent for epoxy resins using the same and a one-component type humidity-curing epoxy resin or urethane prepolymer composition containing the curing agent.
摘要翻译: 具有较少气味的固化剂和提供外观,机械性能,耐水性和耐化学性优异的固化树脂,以及具有优异储存稳定性和提供优异的固化物的单组分型湿度固化树脂组合物 外观和物理性能。 具体地,提供通过使2,5-和/或2,6-双(氨基甲基) - 双环[2.2.1]庚烷与羧酸或酮脱水得到的聚氨基酰胺或酮亚胺,使用其的环氧树脂的固化剂和 含有固化剂的单组分型湿度固化环氧树脂或氨基甲酸酯预聚物组合物。
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公开(公告)号:US5789520A
公开(公告)日:1998-08-04
申请号:US769519
申请日:1996-12-19
申请人: Minato Karasawa , Takeya Abe , Takuji Shimizu , Takeshi Iwaki
发明人: Minato Karasawa , Takeya Abe , Takuji Shimizu , Takeshi Iwaki
IPC分类号: C07C233/35 , C07C233/36 , C07C251/02 , C07C251/08 , C08G18/12 , C08G59/40 , C08G59/44 , C08G59/68 , C08G65/10 , C08L63/00 , C07C251/04
CPC分类号: C08G59/44 , C07C233/35 , C07C233/36 , C07C251/02 , C07C251/08 , C08G18/12 , C08G59/4042 , C08L63/00
摘要: A curing agent having less odor and providing a cured resin which is excellent in appearance, mechanical properties, water resistance and chemical resistance, and a one-component type humidity-curing resin composition having excellent storage stability and providing a cured matter which is excellent in appearance and physical properties. Specifically, provided are polyaminoamide or ketimine obtained by dehydration of 2,5- and/or 2,6-bis(aminomethyl)-bicyclo�2.2.1!heptane with carboxylic acids or ketones, a curing agent for epoxy resins using the same and a one-component type humidity-curing epoxy resin or urethane prepolymer composition containing the curing agent.
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公开(公告)号:US07700330B2
公开(公告)日:2010-04-20
申请号:US09936514
申请日:2001-01-12
申请人: Takeya Abe , Kiyoshi Itou , Kenju Sasaki , Seiichi Watanabe , Tamotsu Asano
发明人: Takeya Abe , Kiyoshi Itou , Kenju Sasaki , Seiichi Watanabe , Tamotsu Asano
CPC分类号: C07C231/24 , C12P13/02
摘要: The invention is to provide a process for effectively removing impurities contained in an amide compound-containing solution by making an amide compound-containing solution, particularly an amide compound-containing solution produced by a hydration reaction of a nitrile compound by using a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body, in contact with activated carbon under acidic conditions.
摘要翻译: 本发明提供一种通过使用含有酰胺化合物的溶液,特别是通过腈化合物的水合反应产生的含酰胺化合物的溶液,通过使用微生物真菌体来有效地除去含酰胺化合物的溶液中所含的杂质的方法 含有腈水合酶或微生物真菌体的加工产物,在酸性条件下与活性炭接触。
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公开(公告)号:US06849432B2
公开(公告)日:2005-02-01
申请号:US09980102
申请日:2001-03-23
申请人: Takeya Abe , Kiyoshi Ito , Kenju Sasaki , Seiichi Watanabe , Toshihisa Tachibana , Tamotsu Asano
发明人: Takeya Abe , Kiyoshi Ito , Kenju Sasaki , Seiichi Watanabe , Toshihisa Tachibana , Tamotsu Asano
摘要: The invention is a process for continuously producing an amide compound by reacting a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body with a nitrile compound in an aqueous medium, characterized in that after contacting said fungus body or said processed product of said fungus body with said nitrile compound in said aqueous medium, a reaction solution thus obtained is further subjected to reaction under conditions having a plug flow region, and according to the invention, an amide compound aqueous solution of a high concentration a high purity can be easily obtained in an extremely high conversion rate of a nitrile compound without a condensation process.
摘要翻译: 本发明是一种通过含腈水合酶的微生物菌体或微生物真菌体的加工产物与腈化合物在水性介质中反应来连续生产酰胺化合物的方法,其特征在于,在使所述真菌体或所述加工产物 的所述真菌体与所述腈化合物在所述水性介质中反应,得到的反应溶液在具有活塞流动区域的条件下进一步反应,根据本发明,高浓度高纯度的酰胺化合物水溶液 可以容易地以非常高的腈化合物的转化率而不会产生冷凝过程。
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