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公开(公告)号：US09952230B2
公开(公告)日：2018-04-24
申请号：US14116155
申请日：2012-05-23
IPC分类号： G01N33/86 , G01N33/541 , G01N33/542 , G01N33/82
CPC分类号： G01N33/86 , G01N33/541 , G01N33/542 , G01N33/82
摘要： A problem to be solved by the present invention is to inhibit a nonspecific agglutination reaction in an agglutination test using a monoclonal antibody having a property of specifically biding to PIVKA-II and a monoclonal antibody having a property of specifically biding to prothrombin as well as two types of carrier particles carrying these monoclonal antibodies. The nonspecific agglutination reaction can be inhibited by adding certain divalent metal ions to a reaction solution containing the monoclonal antibody having a property of specifically biding to PIVKA-II and the monoclonal antibody having a property of specifically biding to prothrombin as well as the two types of carrier particles carrying these monoclonal antibodies.
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2.发明授权Method for enhancing sensitivity or method for avoiding influence of hemoglobin in immunological measurement 有权提高灵敏度的方法或避免血红蛋白在免疫学测量中的影响的方法公开(公告)号：US08722342B2
公开(公告)日：2014-05-13
申请号：US13002467
申请日：2009-07-03
申请人： Mitsuaki Yamamoto , Akiko Suzuki
发明人： Mitsuaki Yamamoto , Akiko Suzuki
IPC分类号： G01N33/53
CPC分类号： G01N33/53 , G01N33/5306
摘要： A method for enhancing measurement sensitivity or avoiding hemoglobin influence in a latex agglutination or metal agglutination immunoassay method of a target antigen in a biological sample that uses calixarene in the immunoassay.
摘要翻译： 在免疫测定中使用杯芳烃的生物样品中的靶抗原的胶乳凝集或金属凝集免疫测定法中提高测量灵敏度或避免血红蛋白影响的方法。
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3.发明申请METHOD OF PRETREATMENT OF SAMPLE FOR QUANTITATING CHOLESTEROL AND METHOD FOR QUANTITATING CHOLESTEROL IN SPECIFIC LIPOPROTEINS BY USING THE SAME 审中-公开用于量化胆固醇的样品预处理方法及使用该定量方法在特定脂蛋白中定量胆固醇的方法公开(公告)号：US20090226945A1
公开(公告)日：2009-09-10
申请号：US12467830
申请日：2009-05-18
IPC分类号： C12Q1/60
CPC分类号： C12Q1/60 , G01N33/92 , G01N2800/044
摘要： A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally together with a reaction accelerator; a method for quantitating cholesterol in specific lipoproteins by using the above method; and a kit for quantitating cholesterol in specific lipoproteins to be used in the above quantification method. By using this quantification method, cholesterol in a specific fraction can be conveniently, accurately and efficiently quantitated fundamentally without resort to polyanion, etc. Thus, this method is appropriately usable in various automatic analyzers.
摘要翻译： 一种用于定量胆固醇的样品的预处理方法，其特征在于，在测定特定脂蛋白中所含的胆固醇之前，任选地与反应促进剂一起用酶处理含有脂蛋白的样品，其底物是游离胆固醇; 通过使用上述方法定量特定脂蛋白中的胆固醇的方法; 以及用于定量在上述定量方法中使用的特定脂蛋白中的胆固醇的试剂盒。 通过使用该定量方法，可以从根本上方便，准确，有效地量化特定部分的胆固醇，而不需要使用聚阴离子等。因此，该方法可适用于各种自动分析装置。
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公开(公告)号：US06979552B2
公开(公告)日：2005-12-27
申请号：US10416166
申请日：2001-11-13
摘要： A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability.
摘要翻译： 一种脂质测定方法，其特征在于在有机硅化合物存在下测定血液成分中所含的脂质。 该方法可以满足直接方法的特定条件，同时满足对测定精度无影响，测定仪器无负担，易于获得的要求。
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5.发明申请Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same 审中-公开用于定量胆固醇的样品的预处理方法和通过使用其来定量特定脂蛋白中的胆固醇的方法公开(公告)号：US20050009125A1
公开(公告)日：2005-01-13
申请号：US10898385
申请日：2004-07-26
CPC分类号： C12Q1/60 , G01N33/92 , G01N2800/044
摘要： A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally together with a reaction accelerator; a method for quantitating cholesterol in specific lipoproteins by using the above method; and a kit for quantitating cholesterol in specific lipoproteins to be used in the above quantification method. By using this quantification method, cholesterol in a specific fraction can be conveniently, accurately and efficiently quantitated fundamentally without resort to polyanion, etc. Thus, this method is appropriately usable in various automatic analyzers.
摘要翻译： 一种用于定量胆固醇的样品的预处理方法，其特征在于，在测定特定脂蛋白中所含的胆固醇之前，任选地与反应促进剂一起用酶处理含有脂蛋白的样品，其底物是游离胆固醇; 通过使用上述方法定量特定脂蛋白中的胆固醇的方法; 以及用于定量在上述定量方法中使用的特定脂蛋白中的胆固醇的试剂盒。 通过使用该定量方法，可以从根本上方便，准确，有效地量化特定部分的胆固醇，而不需要使用聚阴离子等。因此，该方法可适用于各种自动分析装置。
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公开(公告)号：US20150301038A1
公开(公告)日：2015-10-22
申请号：US14129771
申请日：2012-06-29
申请人： Shinya Yokokawa , Mitsuaki Yamamoto , Tomo Shimizu
发明人： Shinya Yokokawa , Mitsuaki Yamamoto , Tomo Shimizu
IPC分类号： G01N33/553 , C07K17/14 , C07K17/08 , C07K16/36 , C07K14/765
CPC分类号： G01N33/553 , C07K14/765 , C07K16/36 , C07K17/08 , C07K17/14
摘要： To adjust detection sensitivity and expand a measurement range depending on objects to be detected by a simple procedure in an immunoassay method involving using a colloidal metal having immobilized thereon an antibody or an antigen. Blocking treatment for a surface of a colloidal metal particle having immobilized thereon an antibody or an antigen with both components, i.e., a component of biological origin and a component of non-biological origin enables adjustment of measurement sensitivity with, for example, kinds and concentrations of both the components, and enables use of the component of non-biological origin, which has not been usable alone because of aggregation of a colloidal metal.
摘要翻译： 为了调整检测灵敏度，根据涉及使用固定有抗体或抗原的胶体金属的免疫测定方法，通过简单的步骤检测的对象扩大测定范围。 在其上固定有抗体或具有两种成分的成分，即生物来源的成分和非生物来源的成分的胶体金属颗粒的表面的封闭处理使得能够例如通过种类和浓度来调节测量灵敏度 并且能够使用由于胶体金属的聚集而单独使用的非生物来源的成分。
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7.发明申请METHOD FOR ENHANCING SENSITIVITY OR METHOD FOR AVOIDING INFLUENCE OF HEMOGLOBIN IN IMMUNOLOGICAL MEASUREMENT 有权提高敏感性的方法或避免HEMOGLOBIN在免疫测量中的影响的方法公开(公告)号：US20110104825A1
公开(公告)日：2011-05-05
申请号：US13002467
申请日：2009-07-03
申请人： Mitsuaki Yamamoto , Akiko Suzuki
发明人： Mitsuaki Yamamoto , Akiko Suzuki
IPC分类号： G01N33/546 , G01N33/543
CPC分类号： G01N33/53 , G01N33/5306
摘要： To provide a technique for enhancing measurement sensitivity or a technique for avoiding a hemoglobin influence in an immunoassay method.The invention is directed to a method for enhancing measurement sensitivity or a hemoglobin influence avoiding method in an immunoassay method, characterized in that the method includes assaying target substance contained in a biological sample through antigen-antibody reaction in the presence of a macrocyclic compound.
摘要翻译： 提供用于提高测量灵敏度的技术或用于在免疫测定方法中避免血红蛋白影响的技术。 本发明涉及一种用于增强免疫测定方法中测量灵敏度或血红蛋白影响避免方法的方法，其特征在于该方法包括在大环化合物存在下通过抗原 - 抗体反应测定生物样品中所含的目标物质。
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公开(公告)号：US20080166746A1
公开(公告)日：2008-07-10
申请号：US12047357
申请日：2008-03-13
摘要： A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability.
摘要翻译： 一种脂质测定方法，其特征在于在有机硅化合物存在下测定血液成分中所含的脂质。 该方法可以满足直接方法的特定条件，同时满足对测定精度无影响，测定仪器无负担，易于获得的要求。
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公开(公告)号：US20130004976A1
公开(公告)日：2013-01-03
申请号：US13518788
申请日：2010-12-27
IPC分类号： G01N33/566 , G01N30/00 , C07K16/26 , G01N33/577
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/33 , C07K2317/34 , G01N2333/62
摘要： A problem of the present invention is to provide an antibody specific to human insulin and an assay and an assay reagent using the antibody capable of accurately assaying human insulin without being affected by porcine insulin. The present invention provides an assay and an assay reagent capable of specifically assaying human insulin by combining a monoclonal antibody specifically reactive with human insulin and nonreactive with porcine insulin and a different anti-human insulin antibody.
摘要翻译： 本发明的一个问题是提供一种对人胰岛素有特异性的抗体以及使用能够精确测定人胰岛素而不受猪胰岛素影响的抗体的测定法和测定试剂。 本发明提供能够通过将与胰岛素特异性反应的单克隆抗体与猪胰岛素和不同抗人胰岛素抗体反应的单克隆抗体结合来特异性测定人胰岛素的测定法和测定试剂。
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公开(公告)号：US20110195438A1
公开(公告)日：2011-08-11
申请号：US13122930
申请日：2010-07-21
CPC分类号： G01N33/74 , C07K16/26 , G01N33/53 , G01N2333/62
摘要： The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.
摘要翻译： 本发明提供一种胰岛素特异性测定法和能够使用具有与结合抗胰岛素抗体结合的胰岛素反应的性质而不与未与抗胰岛素抗体结合的胰岛素反应的抗体敏感且特异性地测定胰岛素的测定试剂 ，而不受胰岛素原和胰岛素类似物的影响。
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