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1.发明授权公开(公告)号：US08367887B2
公开(公告)日：2013-02-05
申请号：US12668838
申请日：2008-07-11
申请人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
发明人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
IPC分类号： G01N33/00 , A01K67/027 , A01K67/033
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/168
摘要： It is intended to provide a simple normal-tension glaucoma model capable of spontaneously, age-dependently and surly developing conditions similar to symptoms of normal-tension glaucoma which occurs more frequently in elder people, and a method of evaluating therapeutic effect on normal-tension glaucoma whereby a drug useful in treating and diagnosing can be conveniently screened by using the normal-tension glaucoma model. A normal-tension glaucoma model comprising a nonhuman mammal, which is deficient in a transcriptional regulator NF-κBp50 and thus spontaneously develops the normal-tension glaucoma symptom age-relatedly, an organ or a tissue thereof or cells collected from any of the same. A method of evaluating therapeutic effect on normal-tension glaucoma of a test substance which comprises administering or adding the test substance to the above-described nonhuman mammal, an organ or a tissue thereof or cells collected from any of the same, and measuring a morphological defect, cell count, pressure, the expression amount or activity strength of a protein, the expression amount of a nucleic acid and/or the activity strength of an antibody in the organ, tissue and/or cells as indication(s) for the evaluation.
摘要翻译： 旨在提供一种能够自发地，年龄依赖性地和显着地发展类似于老年人更频繁发生的正常张力性青光眼症状的正常张力青光眼模型，以及评估对正常张力的治疗效果的方法 通过使用正常张力性青光眼模型，可以容易地筛选可用于治疗和诊断的药物的青光眼。 包含非转基因哺乳动物的正常张力性青光眼模型，其在转录调节因子NF-κBp50中是不足的，因此自发地发生与其相关的正常张力性青光眼症状年龄的器官或其组织或从任何 相同。 评价对被检物质的正常张力性青光眼的治疗效果的方法，其包括向所述非人类哺乳动物，器官或组织施用或添加测试物质或从其中任一种收集的细胞，并测量形态学 缺陷，细胞计数，压力，蛋白质的表达量或活性强度，核酸的表达量和/或器官，组织和/或细胞中抗体的活性强度作为评价指标 。
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2.发明申请NORMAL-TENSION GLAUCOMA MODEL AND METHOD FOR EVALUATION OF TEST SUBSTANCES BY USING SAME 失效用于评估试验物质的正常拉曼光学模型和方法公开(公告)号：US20100204311A1
公开(公告)日：2010-08-12
申请号：US12668838
申请日：2008-07-11
申请人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
发明人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/168
摘要： It is intended to provide a simple normal-tension glaucoma model capable of spontaneously, age-dependently and surly developing conditions similar to symptoms of normal-tension glaucoma which occurs more frequently in elder people, and a method of evaluating therapeutic effect on normal-tension glaucoma whereby a drug useful in treating and diagnosing can be conveniently screened by using the normal-tension glaucoma model. A normal-tension glaucoma model comprising a nonhuman mammal, which is deficient in a transcriptional regulator NF-κBp50 and thus spontaneously develops the normal-tension glaucoma symptom age-relatedly, an organ or a tissue thereof or cells collected from any of the same. A method of evaluating therapeutic effect on normal-tension glaucoma of a test substance which comprises administering or adding the test substance to the above-described nonhuman mammal, an organ or a tissue thereof or cells collected from any of the same, and measuring a morphological defect, cell count, pressure, the expression amount or activity strength of a protein, the expression amount of a nucleic acid and/or the activity strength of an antibody in the organ, tissue and/or cells as indication(s) for the evaluation.
摘要翻译： 旨在提供一种能够自发地，年龄依赖性地和显着地发展类似于老年人更频繁发生的正常张力性青光眼症状的正常张力青光眼模型，以及评估对正常张力的治疗效果的方法 通过使用正常张力性青光眼模型，可以容易地筛选可用于治疗和诊断的药物的青光眼。 包含非转基因哺乳动物的正常张力性青光眼模型，其在转录调节因子NF-κBp50中是不足的，因此自发地发生与其相关的正常张力性青光眼症状年龄的器官或其组织或从任何 相同。 评价对被检物质的正常张力性青光眼的治疗效果的方法，其包括向所述非人类哺乳动物，器官或组织施用或添加测试物质或从其中任一种收集的细胞，并测量形态学 缺陷，细胞计数，压力，蛋白质的表达量或活性强度，核酸的表达量和/或器官，组织和/或细胞中抗体的活性强度作为评价指标 。
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3.发明授权公开(公告)号：US08974836B2
公开(公告)日：2015-03-10
申请号：US13897603
申请日：2013-05-20
申请人： Junya Fujimori , Hidekazu Baba , Toshinori Murata
发明人： Junya Fujimori , Hidekazu Baba , Toshinori Murata
CPC分类号： A61K33/00 , A61K31/21 , A61K33/26 , A61K2300/00
摘要： An angiogenesis regulating composition used to treat/prevent an angiogenic disease in a subject, that contains in an effective amount at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, and an angiogenesis regulation method administering to a subject a composition containing as an active ingredient at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, provide a composition effective in treating and preventing angiogenic diseases, that can medically control angiogenic diseases, and medically regulate angiogenesis in ophthalmologic diseases in particular, and allows treatment without inhibiting physiological neovascularization, with a limited side effect and significantly safely, and an angiogenesis regulation method using the same.
摘要翻译： 用于治疗/预防受试者血管生成疾病的血管发生调节组合物，其在所述化合物被吸收到受试者中之后含有有效量的硝酸盐，亚硝酸盐和可转化为硝酸盐或亚硝酸盐的化合物中的至少一种，以及血管发生 向受试者施用在化合物被吸收到受试者中后，向受试者施用含有硝酸盐，亚硝酸盐和可转化成硝酸盐或亚硝酸盐的化合物中的至少一种作为活性成分的组合物，提供有效治疗和预防血管生成疾病的组合物， 可以医学上控制血管生成疾病，特别是医学上调节眼科疾病的血管生成，并且允许治疗而不抑制生理新血管形成，副作用有限并且显着安全，以及使用其的血管生成调节方法。
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4.发明授权Image signal correction circuit and image signal processor using the circuit 失效图像信号校正电路和图像信号处理器采用该电路
公开(公告)号：US5249037A
公开(公告)日：1993-09-28
申请号：US360227
申请日：1989-06-01
申请人： Masato Sugiyama , Isao Nakagawa , Shigeru Hirahata , Toshinori Murata , Ikuya Arai , Kazuhiro Kaizaki , Tadashi Kasezawa , Noriyuki Yamaguchi , Takuzi Kurashita , Masaharu Yao
发明人： Masato Sugiyama , Isao Nakagawa , Shigeru Hirahata , Toshinori Murata , Ikuya Arai , Kazuhiro Kaizaki , Tadashi Kasezawa , Noriyuki Yamaguchi , Takuzi Kurashita , Masaharu Yao
摘要： In a motion-adaptive television signal processor, a field as a reference for a moving picture signal includes a signal delayed by a frame memory or a field memory. A non-standard signal is beforehand processed so as to separate Y and C signals, and the signal thus processed is input to a motion-adaptive processor to thereby reduce a deviation in center of gravity between a still picture signal and a moving picture signal on the timebase to thereby suppress unnatural motion of the picture.
摘要翻译： 在运动自适应电视信号处理器中，作为运动图像信号的参考的场包括由帧存储器或场存储器延迟的信号。 预先对非标准信号进行处理，以分离Y和C信号，将这样处理的信号输入到运动自适应处理器，从而减少静止图像信号和运动图像信号之间的重心偏差 时基，从而抑制图片的不自然的运动。
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公开(公告)号：US4870490A
公开(公告)日：1989-09-26
申请号：US248375
申请日：1988-09-23
申请人： Hiroshi Sekiya , Ikuya Arai , Toshinori Murata
发明人： Hiroshi Sekiya , Ikuya Arai , Toshinori Murata
CPC分类号： H04N5/126
摘要： In a television receiver including a digital circuit processing an input video signal in a digital mode, a clock generating circuit applies a system clock signal to the digital circuit, and comprises a phase comparator to which a horizontal synchronizing signal is applied, a low-pass filter connected to the phase comparator, a voltage controlled oscillator connected to the low-pass filter to generate the system clock signal, a first frequency divider dividing the frequency of the system clock signal generated from the voltage controlled oscillator to generate a horizontal deflection drive pulse signal, and a second frequency divider connected to the phase comparator. The phase comparator, the low-pass filter, the voltage controlled oscillator, the first frequency divider and the second frequency divider constitute a single PLL circuit, and the system clock signal and the horizontal deflection drive pulse signal are respectively generated from the PLL circuit.
摘要翻译： 在包括以数字模式处理输入视频信号的数字电路的电视接收机中，时钟产生电路将系统时钟信号施加到数字电路，并且包括施加水平同步信号的相位比较器，低通 滤波器连接到相位比较器，压控振荡器连接到低通滤波器以产生系统时钟信号，第一分频器分频从压控振荡器产生的系统时钟信号的频率，以产生水平偏转驱动脉冲 信号和连接到相位比较器的第二分频器。 相位比较器，低通滤波器，压控振荡器，第一分频器和第二分频器构成单个PLL电路，并且系统时钟信号和水平偏转驱动脉冲信号分别从PLL电路产生。
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公开(公告)号：US4736252A
公开(公告)日：1988-04-05
申请号：US932376
申请日：1986-11-20
申请人： Isao Nakagawa , Masahiko Achiha , Masato Sugiyama , Kenji Katsumata , Toshinori Murata , Shigeru Hirahata , Akihide Okuda
发明人： Isao Nakagawa , Masahiko Achiha , Masato Sugiyama , Kenji Katsumata , Toshinori Murata , Shigeru Hirahata , Akihide Okuda
CPC分类号： H04N5/144
摘要： A motion detector for a chrominance signal which is used with a TV receiver equipped with a video signal motion detector. This motion detector for a chrominance signal has a delay element for delaying the chrominance signal of a video signal by 1 frame period, a subtractor for subtracting the output signal of the delay element from the input signal thereof, an absolute value conversion circuit to which the output signal from the subtractor is inputted, and a smoother circuit to which the output signal from the absolute value conversion circuit is supplied. If the chrominance signals of video signals on two consecutive frames are the same, the output signal of the subtractor becomes zero. If the chrominance signals of video signals on two consecutive frames are different, the output signal of the substractor takes a positive or negative value. The negative value signal is converted into a positive value signal by the absolute value conversion circuit. A signal is outputted from the smoother circuit only when the chrominance signals of video signals on two consecutive frames are different. This outputted signal is a chrominance signal motion detection signal. The luminance signal contained in a video signal is removed from the video signal using a comb-type filter.
摘要翻译： 用于与配备有视频信号运动检测器的TV接收机一起使用的色度信号的运动检测器。 用于色度信号的运动检测器具有用于将视频信号的色度信号延迟1帧周期的延迟元件，用于从其输入信号中减去延迟元件的输出信号的减法器，绝对值转换电路， 输入来自减法器的输出信号，并且提供来自绝对值转换电路的输出信号的平滑电路。 如果两个连续帧上的视频信号的色度信号相同，则减法器的输出信号变为零。 如果两个连续帧上的视频信号的色度信号不同，则减法器的输出信号为正或负值。 负值信号由绝对值转换电路转换为正值信号。 仅当两个连续帧上的视频信号的色度信号不同时才从平滑电路输出信号。 该输出信号是色度信号运动检测信号。 使用梳状滤波器从视频信号中去除包含在视频信号中的亮度信号。
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公开(公告)号：US4232397A
公开(公告)日：1980-11-04
申请号：US936923
申请日：1978-08-25
申请人： Toshinori Murata , Shigeo Matsuura
发明人： Toshinori Murata , Shigeo Matsuura
CPC分类号： H03J7/28 , H03J5/0245
摘要： An automatic channel selection apparatus comprises an electronic tuner having a local oscillator an oscillation frequency of which is controlled by an applied voltage, a voltage sweep circuit for sweeping the voltage to be applied to the local oscillator, means for deriving from an output of the local oscillator, signals of different phases and combining those signals, a detector for envelope-detecting an output of the deriving means and means for counting the number of varying cycle periods in the output of the detector which changes periodically each time the oscillation frequency of the local oscillator changes by a given amount which is inversely proportional to the phase difference to change a tuning frequency of the electronic tuner by a specified amount.
摘要翻译： 自动频道选择装置包括具有振荡频率由施加电压控制的本地振荡器的电子调谐器，用于扫描施加到本地振荡器的电压的电压扫描电路，用于从本地振荡器的输出导出的装置 振荡器，不同相位的信号并组合这些信号，用于包络检测导出装置的输出的检测器和用于对每次本地振荡频率周期性地改变的检测器的输出中的变化周期周期数进行计数的装置 振荡器以与相位差成反比的给定量变化，以将电子调谐器的调谐频率改变指定量。
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公开(公告)号：US6040867A
公开(公告)日：2000-03-21
申请号：US803532
申请日：1997-02-20
申请人： Yumi Bando , Takumi Okamura , Toshinori Murata
发明人： Yumi Bando , Takumi Okamura , Toshinori Murata
CPC分类号： H04N5/4401 , H04N21/4345 , H04N21/4384
摘要： A television signal receiving apparatus and method is provided having channel decode means for receiving a signal with a video signal, a sound signal, a data signal, and additional data multiplexed to perform tuning, demodulation, and error correction on the received signal and a demultiplexor for separating the multiplexed signal to output coded data of each of the video signal, the sound signal, and the data signal and for extracting service information as one of additional data. A storage device is provided for storing the service information extracted from the demultiplexor, together with a write controller for controlling writing into the storage device, and a read controller for controlling reading of the storage device according to a user command entered by a user. A source decoder is also provided for decoding the coded data outputted from the demultiplexor using the information outputted from said storage device to output the video signal, the sound signal, and the data signal. The storage device records the service information supplied from the demultiplexor, and the read controller performs control such that necessary data are read from the storage device as required by the user, thereby enhancing the speed of processing associated with the service information to provide a quick response to the user requirement. Also, the write controller can control storage such that only necessary information for the next processing operation is stored, thereby reducing the size of the storage device which is necessary.
摘要翻译： 提供一种电视信号接收装置和方法，其具有信道解码装置，用于接收具有视频信号，声音信号，数据信号和多路复用以对接收信号进行调谐，解调和纠错的附加数据的信号和解复用器 用于将复用的信号分离为输出视频信号，声音信号和数据信号中的每一个的编码数据，并用于将服务信息提取为附加数据之一。 提供一种存储装置，用于存储从解复用器提取的服务信息与用于控制对存储装置的写入的写入控制器，以及用于根据用户输入的用户命令控制存储装置的读取的读取控制器。 还提供了源解码器，用于使用从所述存储装置输出的信息来解码从解复用器输出的编码数据，以输出视频信号，声音信号和数据信号。 存储装置记录从解复用器提供的服务信息，并且读取控制器进行控制，使得根据用户需要从存储装置读取必要的数据，从而提高与服务信息相关联的处理速度以提供快速响应 符合用户要求。 此外，写入控制器可以控制存储器，使得仅存储用于下一个处理操作的必要信息，从而减小必要的存储设备的尺寸。
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9.发明授权
公开(公告)号：US6002797A
公开(公告)日：1999-12-14
申请号：US493104
申请日：1995-06-21
申请人： Takayuki Mori , Nobufumi Nakagaki , Yumi Bando , Shinobu Torikoshi , Sunao Suzuki , Toshinori Murata
发明人： Takayuki Mori , Nobufumi Nakagaki , Yumi Bando , Shinobu Torikoshi , Sunao Suzuki , Toshinori Murata
CPC分类号： G06K9/325 , G06K2209/01
摘要： A boundary position detection apparatus in which the position of an imageless part (containing no meaningful image information) lying at the upper part or/and the lower part of a picture is precisely detected from a video signal. A line decision circuit decides whether each of lines constituting the picture belongs to an image part (containing meaningful image information) or to the imageless part. A boundary decision circuit decides the boundary between the image part and the imageless part. A time integration circuit integrates the detected boundary positions temporally, and determines a final boundary position. A detection control circuit finds an image-part region from the final position, detects the average luminance of the region and controls the integrating time interval of the time integration circuit with the average luminance.
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公开(公告)号：US5272533A
公开(公告)日：1993-12-21
申请号：US820222
申请日：1992-01-14
申请人： Moriyoshi Akiyama , Toshiyuki Kurita , Hiroshi Sekiya , Sunao Suzuki , Katsumi Hishiyama , Toshinori Murata
发明人： Moriyoshi Akiyama , Toshiyuki Kurita , Hiroshi Sekiya , Sunao Suzuki , Katsumi Hishiyama , Toshinori Murata
摘要： An image control apparatus includes a waveform equalizer, a distorted waveform extraction control unit, a noise reduction circuit, and an image quality control unit. The waveform equalizer receives an input video signal, equalizes the waveform of the video signal, and outputs the waveform equalized video signal. The distorted waveform extraction control unit detects a distorted waveform from the output of the waveform equalizer and controls the waveform equalizer to perform waveform equalization suitable for the input video signal. It also controls the noise reduction circuit and the image quality control unit in accordance with changes in the frequency characteristic of the video signal before and after waveform equalization to intensify the noise reduction for degrading the image quality, when the high frequency band of the frequency characteristic of the input signal has been lowered, and, conversely, to debilitate or stop the noise reduction for enhancing the image quality, when the high frequency band has been raised.
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