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公开(公告)号：US09045557B2
公开(公告)日：2015-06-02
申请号：US13256580
申请日：2010-03-15
申请人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe , Yusuke Nakamura , Yoichi Furukawa
发明人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe , Yusuke Nakamura , Yoichi Furukawa
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , A61K39/39 , A61K2039/53 , A61K2039/572 , C12N9/88 , C12Y402/99018 , Y02A50/396
摘要： The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences. The invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for diagnosing or treating cancer.
摘要翻译： 本发明提供分离的肽或衍生自SEQ ID NO：45的片段，其结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL）。 肽可以包括具有取代缺失的上述氨基酸序列，或加入一个，两个或几个氨基酸序列。 本发明还提供了包括这些肽的药物组合物。 本发明的肽可用于诊断或治疗癌症。
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公开(公告)号：US20120093845A1
公开(公告)日：2012-04-19
申请号：US13256580
申请日：2010-03-15
申请人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa watanabe , Yusuke Nakamura , Yoichi Furukawa
发明人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa watanabe , Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K39/00 , C07H21/00 , C12N5/078 , C12N15/85 , C07K14/74 , C07K16/18 , C12N15/63 , C12N5/0783 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/574 , A61P35/00 , A61P37/04 , C07K7/06
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , A61K39/39 , A61K2039/53 , A61K2039/572 , C12N9/88 , C12Y402/99018 , Y02A50/396
摘要： The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences. The invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for diagnosing or treating cancer.
摘要翻译： 本发明提供分离的肽或衍生自SEQ ID NO：45的片段，其结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL）。 肽可以包括具有取代缺失的上述氨基酸序列，或加入一个，两个或几个氨基酸序列。 本发明还提供了包括这些肽的药物组合物。 本发明的肽可用于诊断或治疗癌症。
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公开(公告)号：US08674059B2
公开(公告)日：2014-03-18
申请号：US11913228
申请日：2006-07-21
IPC分类号： A61K38/00
CPC分类号： G01N33/57419 , C07K16/18 , C07K16/3046 , G01N2500/00
摘要： Objective methods for detecting and diagnosing colon cancer are described herein. In one embodiment, the diagnostic method involves determining the expression level of TOM34 that discriminates between colon cancer cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of colon cancer, methods of treating colon cancer and method for vaccinating a subject against colon cancer.
摘要翻译： 本文描述了用于检测和诊断结肠癌的客观方法。 在一个实施方案中，诊断方法包括确定区分结肠癌细胞和正常细胞的TOM34的表达水平。 最后，本发明提供筛选可用于治疗结肠癌的治疗剂，治疗结肠癌的方法和接种个体对结肠癌的方法。
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公开(公告)号：US08642724B2
公开(公告)日：2014-02-04
申请号：US11913228
申请日：2006-07-21
IPC分类号： A61K38/00
摘要： Objective methods for detecting and diagnosing colon cancer are described herein. In one embodiment, the diagnostic method involves determining the expression level of TOM34 that discriminates between colon cancer cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of colon cancer, methods of treating colon cancer and method for vaccinating a subject against colon cancer.
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公开(公告)号：US07847065B2
公开(公告)日：2010-12-07
申请号：US12175092
申请日：2008-07-17
IPC分类号： C07K14/435 , C07K7/00
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US20100016220A1
公开(公告)日：2010-01-21
申请号：US12175092
申请日：2008-07-17
IPC分类号： A61K38/16 , C07K14/435 , A61P35/04
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US20090012032A1
公开(公告)日：2009-01-08
申请号：US12180204
申请日：2008-07-25
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US07425612B2
公开(公告)日：2008-09-16
申请号：US10916064
申请日：2004-08-10
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US20120190628A1
公开(公告)日：2012-07-26
申请号：US12910015
申请日：2010-10-22
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US07705141B2
公开(公告)日：2010-04-27
申请号：US12180204
申请日：2008-07-25
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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