公开(公告)号：US20160045517A1

公开(公告)日：2016-02-18

申请号：US14860680

申请日：2015-09-21

申请人： Tao Tom Du ,  Chang Lee

发明人： Tao Tom Du ,  Chang Lee

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K31/58

CPC分类号： A61K31/573 ,  A61K9/0075 ,  A61K9/0078 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58

摘要： The present invention relates to the formulations, methods and kits for reducing cytokine interleukin-17 (IL-17 or IL-17A) levels in both broncheoalveolar lavage fluid (BALF) and blood/serum and/or for the inhibition of p38 mitogen activating protein kinase (MAPK) activity involving the use of 17α-hydroxyprogesterone caproate (17-OHPC) or derivatives thereof. The formulation may be in the form of an inhalant containing effective amounts of 17-OHPC, and the formulation may be used in a method to treat IL-17 cytokine and/or p38 MAPK mediated auto-immune and auto-inflammatory diseases. Such diseases may include glucocorticoid (GC) insensitive related diseases or conditions. In alternate embodiment, the formulation may include the combined use of budesonide (BUD) with 17-OPHC.

摘要翻译： 本发明涉及减少支气管肺泡灌洗液（BALF）和血液/血清中和/或抑制p38丝裂原活化蛋白的细胞因子白细胞介素-17（IL-17或IL-17A）水平的制剂，方法和试剂盒 涉及使用17α-羟孕酮己酸酯（17-OHPC）或其衍生物的激酶（MAPK）活性。 制剂可以是含有有效量的17-OHPC的吸入剂的形式，并且该制剂可用于治疗IL-17细胞因子和/或p38MAPK介导的自身免疫和自身炎性疾病的方法。 这些疾病可能包括糖皮质激素（GC）不敏感的相关疾病或病症。 在替代实施方案中，制剂可以包括布地奈德（BUD）与17-OPHC的组合使用。

公开(公告)号：US20160045396A1

公开(公告)日：2016-02-18

申请号：US14860578

申请日：2015-09-21

申请人： Chang Lee ,  Tao Tom Du

发明人： Chang Lee ,  Tao Tom Du

IPC分类号： A61J3/02 ,  A61K9/16 ,  A61K9/00 ,  A61K31/573 ,  A61K31/58

CPC分类号： A61J3/02 ,  A61K9/0019 ,  A61K9/0075 ,  A61K31/56 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58

摘要： The present invention relates to a pharmaceutical formulation powder that contains 17α-hydroxyprogesterone caproate (17-OHPC) powder and the method of producing the formulation produces particles that are suitable as an inhalant. The formulations, methods and kits of powdered 17-OHPC as taught herein may be used to reduce cytokine interleukin-17 (IL-17 or IL-17A) levels in both broncheoalveolar lavage fluid (BALF) and blood/serum and involve the inhibition of p38 mitogen activating protein kinase (MAPK) activity. The 17-OHPC powder formulation may be used in a method to treat IL-17 cytokine and/or p38 MAPK mediated auto-immune and auto-inflammatory diseases. Such diseases may include glucocorticoid (GC) insensitive related diseases or conditions. In alternate embodiment, the formulation may include the combined use of budesonide (BUD) and/or fluticasone with 17-OPHC.

摘要翻译： 本发明涉及含有17α-羟基孕酮己酸酯（17-OHPC）粉末的药物制剂粉末，并且制备该制剂的方法产生适合作为吸入剂的颗粒。 本文教导的粉末状17-OHPC的制剂，方法和试剂盒可用于减少支气管肺泡灌洗液（BALF）和血液/血清中的细胞因子白细胞介素-17（IL-17或IL-17A）水平，并且涉及抑制 p38丝裂原活化蛋白激酶（MAPK）活性。 17-OHPC粉末制剂可用于治疗IL-17细胞因子和/或p38MAPK介导的自身免疫和自身炎症性疾病的方法。 这些疾病可能包括糖皮质激素（GC）不敏感的相关疾病或病症。 在替代实施方案中，制剂可以包括布地奈德（BUD）和/或氟替卡松与17-OPHC的组合使用。

公开(公告)号：US09576122B2

公开(公告)日：2017-02-21

申请号：US13093141

申请日：2011-04-25

申请人： Chang Lee

发明人： Chang Lee

IPC分类号： G06F21/36 ,  G06F3/0488

CPC分类号： G06F21/36 ,  G06F3/04886

摘要： An electronic device comprises a CPU, and a touch-sensitive screen operable to display a plurality of keys. Each of the plurality of keys are associated with and exhibit a predetermined value, where the keys are arranged so that the predetermined values of the keys are displayed in a random manner. The predetermined values of the plurality of keys have different predetermined display characteristics associated therewith so that the plurality of keys have varied appearances.

摘要翻译： 电子设备包括CPU和可操作以显示多个键的触敏屏幕。 多个键中的每一个与预定值相关联并且呈现预定值，其中键被布置成使得键的预定值以随机方式显示。 多个键的预定值具有与其相关联的不同的预定显示特性，使得多个键具有不同的外观。

公开(公告)号：US20110152840A1

公开(公告)日：2011-06-23

申请号：US12971900

申请日：2010-12-17

申请人： Chang Lee ,  Robert Birch

发明人： Chang Lee ,  Robert Birch

IPC分类号： A61M37/00

CPC分类号： A61K31/57 ,  A61K45/06

摘要： The present invention relates to methods and kits for reducing the occurrence of preterm delivery and other pregnancy-related conditions in pregnant female subjects exhibiting one or more risk factors for preterm delivery and other pregnancy-related conditions. For example, the present invention relates to methods for reducing the occurrence of preterm delivery in a pregnant female subject having no history of preterm delivery and exhibiting one or more risk factors for preterm delivery (e.g., smoking during pregnancy). The methods and kits provide for the administration of a steroid hormone to the pregnant female subject.

摘要翻译： 本发明涉及用于减少在早产和其它妊娠相关病症中出现一种或多种危险因素的怀孕女性受试者中早产和其他妊娠相关病症发生的方法和试剂盒。 例如，本发明涉及用于减少在没有早产史的怀孕女性受试者中表现出早产的一个或多个危险因素（例如怀孕期间的吸烟）的早产的发生的方法。 该方法和试剂盒提供给孕妇受试者的类固醇激素的给药。

公开(公告)号：US20080288015A1

公开(公告)日：2008-11-20

申请号：US12150052

申请日：2008-04-23

申请人： Amir J. Tehrani ,  Rose Province ,  Chang Lee ,  David Ligon

发明人： Amir J. Tehrani ,  Rose Province ,  Chang Lee ,  David Ligon

IPC分类号： A61N1/36

CPC分类号： A61N1/3601 ,  A61N1/0504 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514

摘要： A method for treating a patient is provided where a sensed cardiac rhythm is used to adjust electrical stimulation that is used to activate a diaphragm to cause contraction. A cardiac rhythm management device in combination with a diaphragm stimulation device is also provided which includes a cardiac stimulation device configured to provide stimulation to control cardiac rhythm of a subject; and an electrical stimulation device configured to provided electrical stimulation to a subject to activate a diaphragm to increase functional residual capacity of the subject.

摘要翻译： 提供了一种用于治疗患者的方法，其中使用感测的心律来调节用于激活隔膜以引起收缩的电刺激。 还提供了一种与隔膜刺激装置组合的心律管理装置，其包括被配置为提供刺激以控制受试者的心律的心脏刺激装置; 以及电刺激装置，其被配置为向对象提供电刺激以激活膈肌以增加受试者的功能残余容量。

公开(公告)号：US20070092984A1

公开(公告)日：2007-04-26

申请号：US11320701

申请日：2005-12-30

申请人： Chang Lee

发明人： Chang Lee

IPC分类号： H01L21/00

CPC分类号： H01L27/14627 ,  H01L27/14632 ,  H01L27/14687

摘要： An image sensor includes a semiconductor substrate; a pixel array disposed on the semiconductor substrate; and an insulating interlayer, formed on the semiconductor substrate, having a trench coinciding with the disposition of the pixel array, the trench having uniformly inclined inner sidewalls.

摘要翻译： 图像传感器包括半导体衬底; 设置在所述半导体基板上的像素阵列; 以及形成在所述半导体基板上的具有与所述像素阵列的配置重合的沟槽的绝缘夹层，所述沟槽具有均匀倾斜的内侧壁。

公开(公告)号：US20070034173A1

公开(公告)日：2007-02-15

申请号：US11199071

申请日：2005-08-09

申请人： Chang Lee

发明人： Chang Lee

IPC分类号： F02F1/06

CPC分类号： F02F1/30

摘要： A heat dispensing device for a cylinder includes a plurality of curve fins and each fin has a first end axially extending from an outer surface of the cylinder body and a second end of each of the fins has a Y-shaped distal end which increases the area for dispensing heat. The fins extend clockwise or counter clockwise to guide airflow to smoothly pass through the gaps between the fins.

摘要翻译： 一种用于气缸的散热装置包括多个曲线翅片，每个翅片具有从气缸本体的外表面轴向延伸的第一端，并且每个翅片的第二端具有Y形远端， 用于分配热量。 翅片顺时针或逆时针延伸，以引导气流平滑地穿过翅片之间的间隙。

公开(公告)号：US20070004145A1

公开(公告)日：2007-01-04

申请号：US11318960

申请日：2005-12-27

申请人： Jong Kim ,  Chang Lee ,  Jong Kim ,  Se Won

发明人： Jong Kim ,  Chang Lee ,  Jong Kim ,  Se Won

IPC分类号： H01L21/336

CPC分类号： H01L21/28061 ,  H01L21/30604 ,  H01L21/3065 ,  H01L21/3081 ,  H01L29/66621

摘要： A varying-width recess gate structure having a varying-width recess formed in a semiconductor device can sufficiently increase the channel length of the transistor having a gate formed in the varying-width recess, thereby effectively reducing the current leakage and improving the refresh characteristics. In the method of manufacturing the recess gate structure, etching is performed twice or more, so as to form a gate recess having varying width in the substrate, and a gate is formed in the gate recess.

摘要翻译： 具有形成在半导体器件中的可变宽度凹部的变宽的凹槽栅极结构可以充分增加形成在可变宽度凹部中的栅极的晶体管的沟道长度，从而有效地减小漏电流并提高刷新特性。 在制造凹槽栅结构的方法中，进行两次或更多次的蚀刻，以形成在衬底中具有变化的宽度的栅极凹槽，并且在栅极凹部中形成栅极。

公开(公告)号：US20060290612A1

公开(公告)日：2006-12-28

申请号：US11297341

申请日：2005-12-09

申请人： Yong Ha ,  Chang Lee ,  In Seo

发明人： Yong Ha ,  Chang Lee ,  In Seo

IPC分类号： G09G3/30

CPC分类号： G09G3/3275 ,  G09G3/325 ,  G09G2300/0408 ,  G09G2300/0426 ,  G09G2310/0294 ,  G09G2310/0297 ,  G11C27/024 ,  G11C27/028

摘要： A current sample-and-hold circuit of the present invention includes a storage capacitor for storing an initial image-signal current, a first transistor for receiving one of an initial image-signal current from a voltage power supply and an input image-signal current from a pixel circuit, a second transistor for connecting between the first thin film transistor and a first ground, a third transistor and a fourth transistor for biasing the gates of the first and second transistors to sample and hold the initial image-signal current using a second ground in response to a control signal and sinking the input image-signal current from a pixel circuit to the first ground in response to receiving the input image-signal current from the pixel circuit.

摘要翻译： 本发明的电流采样保持电路包括用于存储初始图像信号电流的存储电容器，用于接收来自电压电源的初始图像信号电流和输入图像信号电流之一的第一晶体管 从像素电路，用于连接第一薄膜晶体管和第一接地之间的第二晶体管，第三晶体管和第四晶体管，用于偏置第一和第二晶体管的栅极，以采样和保持初始图像信号电流，使用 响应于接收到来自像素电路的输入图像信号电流，响应于控制信号而将输入图像信号电流从像素电路吸收到第一接地的第二接地。

公开(公告)号：US20060254481A1

公开(公告)日：2006-11-16

申请号：US11431527

申请日：2006-05-11

申请人： Chang Lee ,  Yong Kwon

发明人： Chang Lee ,  Yong Kwon

IPC分类号： A47B9/00

CPC分类号： F25D25/02 ,  F25D2325/022

摘要： The present invention relates to a shelf for a refrigerator, and a refrigerator having the same. A shelf for a refrigerator according to the present invention comprises a support plate 22 having an upper surface on which an article is to be put; a frame 24 formed to correspond to the shape of a periphery of the support plate 22 and having, at an inner side thereof, a coupling portion 30 to which the support plate 22 is coupled to the coupling portion 30 by means of a bonding member 32; and a fixing device for fixing the support plate 22 to the coupling portion 30. At this time, the fixing device may comprise a fixing member 34 having a supporting protrusion 34b penetrating though a sidewall of the frame 24 to support the support plate 22 from below. Alternatively, the fixing device may comprise an elastically deformable resilient hook and a fixing protrusion formed to face the resilient hook all of which are provided on the frame. With the shelf for a refrigerator according to the present invention constructed as above, there are advantages in that the shelf has a secure coupling structure, the process of coupling the components of the shelf is simplified, the shelf has improved durability, and production costs are reduced.

摘要翻译： 冰箱用搁板及其制造方法技术领域本发明涉及一种冰箱用搁板及具有该搁板的冰箱。 根据本发明的用于冰箱的搁架包括：支撑板22，其具有在其上放置物品的上表面; 形成为对应于支撑板22的周边的形状的框架24，并且在其内侧具有联接部分30，支撑板22借助于接合部件32联接到联接部分30 ; 以及用于将支撑板22固定到联接部分30的固定装置。此时，定影装置可以包括固定构件34，固定构件34具有贯穿框架24的侧壁穿过的支撑突起34b，以将支撑板22从 下面。 或者，定影装置可以包括可弹性变形的弹性钩和形成为面向所有这些被设置在框架上的弹性钩的固定突起。 根据如上构造的根据本发明的冰箱的搁架，其优点在于搁架具有固定的联接结构，简化了搁板部件的联接过程，搁板具有改善的耐久性，并且生产成本是 减少