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公开(公告)号：US12102941B2
公开(公告)日：2024-10-01
申请号：US17383117
申请日：2021-07-22
发明人： Venkataramana Runkana , Venkata Sudheendra Buddhiraju , Aditya Pareek , Vishnu Swaroopji Masampally , Karundev Premraj
CPC分类号： B01D15/3809 , B01D15/1885 , C07K1/16 , C07K1/36 , G01N30/466
摘要： The disclosure generally relates to methods and systems for determining multi-column chromatography process configuration for capturing antibodies. Conventional approaches for design of MCC configuration are limited to rule based, either driven by UV spectroscopic measurements or by performing number of experiments, which involves a lot of material costs and time utilization. The present disclosure solves the technical problem of identifying the operational conditions that optimized the MCC process and the MCC configuration. A multi-objective optimization function defined with one or more decision variables associated with the operating conditions is considered to determine the optimal MCC configuration, while satisfying purification goals. The one or more key performance measures of the MCC process comprises a productivity, a capacity utilization, a product yield, and a product purity. The significant amount of time and the material cost invested for designing the optimum MCC configuration is decreased by the present disclosure.
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公开(公告)号：US20240249043A1
公开(公告)日：2024-07-25
申请号：US18524400
申请日：2023-11-30
发明人： Swati Sahu , Vishnu Swaroopji Masampally , Venkata Sudheendra Buddhiraju , Venkataramana Runkana , Aswin Muthachikavil
IPC分类号： G06F30/25 , G06F119/02
CPC分类号： G06F30/25 , G06F2119/02
摘要： This disclosure relates generally to system and method for identifying suitable equipment for pelletizations of particles. Conventional approaches for identifying pelletization equipment for a process are cumbersome and unmethodical. Even though, methods of identifying optimal operating conditions in a particular equipment for a desired product specification are widely discussed in literature, these research works lack in considering practical criteria like equipment cost, equipment capacity, equipment maintenance, etc., in addition to product specifications while deciding a suitable pelletization equipment. Present disclosure provides system and method that involve optimization to identify the best range of operating parameters in a pelletization equipment to achieve desired product size distribution for a given feed size distribution. The method is then used in a system for comparing different pelletization equipment based on different criteria and identifying a suitable pelletization equipment amongst them for use in obtaining pellets with desired product attributes.
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3.发明授权公开(公告)号：US11307327B2
公开(公告)日：2022-04-19
申请号：US16662719
申请日：2019-10-24
发明人： Venkataramana Runkana , Nagaravi Kumar Varma Nadimpalli , Aditya Pareek , Vishnu Swaroopji Masampally
摘要： Monitoring and analysis of plurality of operations in mining and mineral processing is critical to achieve optimized performance. Existing tools are specific to one or other individual operations and this individuality introduces limitations for end to end monitoring of entire mining to mineral processing operations. Method and system for online monitoring and optimization of mining and mineral processing operations providing an integrated approach utilizing short-term mining plan data, information generated using established drill and blast design software, simulation models of fragmentation, crushing, screening, grinding and flotation to arrive at an optimized charge plan and set points for controllers is disclosed. The proposed method and system improves key performance indicators such as cost of mining operations, specific energy consumption in comminution circuit, maximizes yield of desired particle size, and maximizes grade and recovery of mineral of interest while considering operational constraints.
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公开(公告)号：US12050448B2
公开(公告)日：2024-07-30
申请号：US17586995
申请日：2022-01-28
发明人： Venkata Sudheendra Buddhiraju , Venkataramana Runkana , Vishnu Swaroopji Masampally , Anshul Agarwal , Amey Ahsok Kulkarni , Keshari Nandan Gupta , Navnath Manohar Deore , Vinesh Balakrishnan Yezhuvath , Anamika Tiwari , Anurag Singh Rathore , Garima Thakur , Nikita Saxena , Shantanu Banerjee
CPC分类号： G05B19/054 , G05B19/056 , G06N5/01 , G05B2219/13149 , G05B2219/14058 , G05B2219/14083
摘要： Process control of continuous production of biomolecules is a major challenge due to complex nature of processes and time scales of operations involved. Availability of key process variables in real-time is one of main requirements. This disclosure relates to a processor implemented method of controlling a continuous bioprocessing plant which includes at least one of: receiving, an input data associated with one or more equipments; generating, by a recipe builder, a sequence of unit operations to determine at least one job order based on the at least input data; obtaining, a control decision associated with a control parameter based on the at least one job order; communicating, via the middleware, the control decision associated with the control parameter to the PLC; and executing, by a control system of the PLC, the control decision on a unit equipment to control: (i) a continuous bioprocessing train, and (ii) an individual unit operation.
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公开(公告)号：US12039434B2
公开(公告)日：2024-07-16
申请号：US17309432
申请日：2019-11-28
发明人： Vishnu Tankasala Veparala , Solomon Pushparaj Manuelraj , Ankit Bansal , Pankaj Malhotra , Lovekesh Vig , Gautam Shroff , Venkataramana Runkana , Sivakumar Subramanian , Aditya Pareek , Vishnu Swaroopji Masampally , Nishit Raj
摘要： This disclosure relates to optimizing an operation of an equipment by a neural network based optimizer is provided. The method include receiving, information associated with at least one equipment instance (j) as an input at a predefined sequence of timestamps; training, a plurality of simulation models for each equipment instance to obtain a function (fj); processing, the external input parameters (et) to obtain a fixed-dimensional vector and passed as an input to obtain an vector (it); generating, a modified (it) from the output vector (it) based on a domain constraint value; computing, a reward (rt) based on (i) the function (fj), (ii) the modified (it), (iii) the external input parameters (et), and (iv) a reward function (Rj); and iteratively performing the steps of processing, generating, and computing reward (rt) for a series of subsequent equipment instances after expiry of the predefined sequence of timestamps associated with a first equipment instance.
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公开(公告)号：US12038740B2
公开(公告)日：2024-07-16
申请号：US17450243
申请日：2021-10-07
发明人： Kalyani Zope , Sri Harsha Nistala , Venkataramana Runkana , Aditya Pareek , Vishnu Swaroopji Masampally
IPC分类号： G05B19/418 , G06F18/231
CPC分类号： G05B19/4184 , G05B19/4183 , G05B19/4188 , G06F18/231
摘要： This disclosure relates to a method and system for regime-based process optimization of various assets of industrial manufacturing and process plants or units. Operating regimes of assets are identified and a regime similarity score of each asset is computed from regime sequences of integrated industrial data and compared with a given threshold to identify regimes of operation. Operating regimes are matched with regimes of regime database and industrial assets and similar operating regimes are group together. Process optimization is carried out for each group of industrial assets to identify optimum settings in order to maximize output or minimize loss/cost considering process and equipment constraints. Anomalies are analyzed in the unmatched operating regimes and a diagnosis is carried out to identify the root cause for any detected anomalies. Remaining useful life of components in the assets with unmatched operating regimes is estimated to ensure component reliability and to prevent failure.
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