公开(公告)号：US5748305A

公开(公告)日：1998-05-05

申请号：US670851

申请日：1996-06-28

申请人： Ken Shimono ,  Tatsuo Nagasaki ,  Kenji Takamoto ,  Masami Ito ,  Kanji Nishii

发明人： Ken Shimono ,  Tatsuo Nagasaki ,  Kenji Takamoto ,  Masami Ito ,  Kanji Nishii

IPC分类号： G01B11/30 ,  G01N21/88 ,  G01N21/94 ,  G01N21/956 ,  H01L21/66 ,  H05K3/00 ,  G01N21/00

CPC分类号： G01N21/94

摘要： A method for foreign particles inspection includes illuminating an inspection surface of an inspection object with a beam which is, one of s-polarized and p-polarized relative to the inspection surface of the inspection object. The illumination utilizes an optical axis which is generally parallel to the inspection surface or which intersects the inspection surface at an angle that is greater than or equal to 1.degree. and less than 5.degree.. Reflected and scattered light is detected utilizing an optical axis which makes an acute angle with the inspection surface and which makes a differential angle of 30.degree. or less with the optical axis of the illumination beam. The detection of foreign particles is accomplished by detecting the component of the reflected and scattered light which is the other of s-polarized and p-polarized relative to the inspection surface.

摘要翻译： 外来粒子检查方法包括用相对于检查对象的检查面的s偏振和p偏振光束照射检查对象的检查面。 照明使用大致平行于检查表面的光轴，或者以大于或等于1度且小于5度的角度与检查表面相交的光轴。 使用与检查面成锐角的光轴来检测反射散射光，并且与照明光束的光轴成30°以下的差角。 通过检测相对于检查表面的s偏振和p偏振中的另一个的反射和散射光的分量来实现异物的检测。

公开(公告)号：US6144446A

公开(公告)日：2000-11-07

申请号：US980817

申请日：1997-12-01

申请人： Tatsuo Nagasaki ,  Ken Shimono

发明人： Tatsuo Nagasaki ,  Ken Shimono

IPC分类号： G01N21/88 ,  G01N21/94 ,  G01N21/95 ,  G01N21/958 ,  G09G3/00 ,  G09G3/36

CPC分类号： G01N21/958 ,  G01N21/94 ,  G09G3/006 ,  G09G3/36

摘要： An inspecting method for inspecting foreign substances, comprising projecting beams from an illumination system arranged above a light-permeable body to be inspected with an angle of incidence of a first elevation angle onto an upper face of the body, and receiving a reflecting light and a scattering light generated by the beams with a photodetecting angle of a second elevation angle by a photodetecting system. The method further comprising, before the beams are projected, setting a width of the beams of the illumination system to be not larger than w calculated according to an expression w

摘要翻译： 一种用于检查异物的检查方法，包括将待检查的透光体上方的照明系统的光束投射到身体上表面上的第一仰角的入射角，并且接收反射光和 通过光检测系统散射具有第二仰角的光检测角的光束产生的光。 该方法还包括在投影光束之前，将照明系统的光束的宽度设定为不大于根据表达式w <2 *sinα* t {tan [sin-1 {sin（90） 从入射角α，光电检测角度θ，体的厚度t和折射率n开始，tan [sin-1 {sin（θ-90°）/ n}]} 身体上的一种物质。

公开(公告)号：US5717485A

公开(公告)日：1998-02-10

申请号：US637230

申请日：1996-04-24

申请人： Masami Ito ,  Kenji Takamoto ,  Kanji Nishii ,  Tatsuo Nagasaki ,  Ken Shimono

发明人： Masami Ito ,  Kenji Takamoto ,  Kanji Nishii ,  Tatsuo Nagasaki ,  Ken Shimono

IPC分类号： G01B11/30 ,  G01N21/88 ,  G01N21/94 ,  G01N21/956 ,  G06T1/00 ,  H01L21/66 ,  G01N21/00

CPC分类号： G01N21/94

摘要： A foreign substance inspection apparatus having a good signal to noise ratio with optical detection accuracy capable of detecting infinitesimal foreign substances, comprising a lighting portion to irradiate with an S polarized laser light beam and having the optical axis parallel to the substrate to be inspected, a detecting portion having an optical axis located in a position set by rotating the optical axis of the lighting portion by 120.degree. to 160.degree. with the point of intersection of the optical axis of the lighting portion and the surface to be inspected as the center of rotation so as to have an angle made with the surface to be inspected of 45.degree. or smaller to detect the area irradiated from the lighting portion by detecting the S polarized component in the scattered component from the foreign substances existing on the surface to be inspected and converting the S polarized component photoelectrically to a signal, and a signal processing portion to detect a foreign substance based on the signal outputted from the detecting portion.

摘要翻译： 具有能够检测无限小杂质的具有良好的信噪比与检测精度的异物检查装置，包括用S偏振激光束照射并使光轴平行于要检查的基板的照明部， 检测部分，其光轴位于通过将照明部分的光轴与要检查的表面的相交点作为旋转中心的位置使照明部分的光轴旋转120度至160度所设定的位置 以使被检查面的角度为45°以下，通过检测来自存在于被检测面上的异物的散射成分中的S偏振成分来检测照明部照射的面积，并进行转印 光信号的S偏振光分量和检测异物ba的信号处理部 关于从检测部分输出的信号。

公开(公告)号：USRE37977E1

公开(公告)日：2003-02-04

申请号：US09953412

申请日：2001-09-11

申请人： Hirokazu Sugihara ,  Hiroaki Oka ,  Ken Shimono ,  Ryuta Ogawa ,  Makoto Taketani

发明人： Hirokazu Sugihara ,  Hiroaki Oka ,  Ken Shimono ,  Ryuta Ogawa ,  Makoto Taketani

IPC分类号： G01N2700

CPC分类号： G01N33/4836 ,  C12M41/46

摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

摘要翻译： 本发明涉及一种低阻抗电池电位测量电极组件，通常在绝缘衬底上具有许多微电极，并且具有围绕包括微电极的区域的壁。 该装置能够在微电极区域中培养那些细胞或组织的同时使用微电极测量被监测样品的电生理活性。 本发明利用独立的参考电极来降低整个系统的阻抗并因此降低测量数据中常常固有的噪声。 最佳地，微电极由用于控制被监测样品周围大气的物理壁包围。

公开(公告)号：US6132683A

公开(公告)日：2000-10-17

申请号：US220981

申请日：1998-12-23

申请人： Hirokazu Sugihara ,  Hiroaki Oka ,  Ken Shimono ,  Ryuta Ogawa ,  Makoto Taketani

发明人： Hirokazu Sugihara ,  Hiroaki Oka ,  Ken Shimono ,  Ryuta Ogawa ,  Makoto Taketani

IPC分类号： C12M1/34 ,  G01N33/487 ,  G01N27/26

CPC分类号： C12M41/46 ,  G01N33/4836

摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

公开(公告)号：US06256066B1

公开(公告)日：2001-07-03

申请号：US08881334

申请日：1997-06-24

申请人： Noriaki Yukawa ,  Hideshi Ueda ,  Tsuyoshi Nomura ,  Ken Shimono

发明人： Noriaki Yukawa ,  Hideshi Ueda ,  Tsuyoshi Nomura ,  Ken Shimono

IPC分类号： H04N5225

CPC分类号： H04N5/2259 ,  H04N5/349

摘要： A high-resolution image pickup method includes dividing each of a plurality of light-receiving pixels of an image pickup sensor for capturing image information on an inspection subject into a plurality of regions, and capturing the image information from the inspection subject for each of the divided regions, thereby finally capturing image information on the inspection subject with all the regions of the light-receiving pixels.

摘要翻译： 高分辨率图像拾取方法包括将用于将检查对象上的图像信息的摄像传感器的多个受光像素中的每一个划分为多个区域，并且从每个检测对象中检索来自检查对象的图像信息 从而最终在受光像素的所有区域捕获检查对象的图像信息。

公开(公告)号：US20050118565A1

公开(公告)日：2005-06-02

申请号：US10966405

申请日：2004-10-15

申请人： Ken Shimono ,  Victor Panchenko ,  Makoto Taketani ,  Michael Krause

发明人： Ken Shimono ,  Victor Panchenko ,  Makoto Taketani ,  Michael Krause

IPC分类号： A61K31/42 ,  A61K31/55 ,  A61K33/00 ,  A61K33/40 ,  C12Q1/00 ,  G01N33/487 ,  G01N33/543

CPC分类号： A61K33/00 ,  A61K33/40 ,  G01N33/48707 ,  G01N33/5438 ,  G01N2500/00

摘要： The invention relates to systems and methods for assessing neuronal degeneration in vitro. A multielectrode probe is used to culture and measure synaptic transmission of a neuronal sample in the presence of various compounds and culturing conditions capable of inducing or protecting against neuronal damage.

摘要翻译： 本发明涉及用于评估体外神经元变性的系统和方法。 多电极探针用于在存在各种化合物和能够诱导或保护免受神经损伤的培养条件下培养和测量神经元样品的突触传递。

公开(公告)号：US06511817B1

公开(公告)日：2003-01-28

申请号：US09602629

申请日：2000-06-21

申请人： Gary Lynch ,  Makoto Taketani ,  Ken Shimono ,  Hirokazu Sugihara

发明人： Gary Lynch ,  Makoto Taketani ,  Ken Shimono ,  Hirokazu Sugihara

IPC分类号： C12Q102

CPC分类号： G01N33/48714 ,  G01N33/48707 ,  G01N33/5088 ,  G01N33/94

摘要： This relates to methods for the detection of psychoactive compounds in an in vitro neuronal tissue sample by detecting oscillations of extracellular voltage desirably before and after the introduction of a candidate sample onto an in vitro neuronal tissue sample and for devices useful in practicing the methods. Analysis of the extracellular voltage parameters leads to indication of the presence of psychoactive material in the candidate sample and information as to its pharmacological activity and/or composition. Further, it relates to a process of initiating and maintaining the presence of repetitive neuronal activity within the in vitro sample. Additionally, this includes a method for the stimulation of or initiation of repetitive neuronal activity, e.g., EEG, in an in vitro neuronal tissue sample by introducing a stimulating composition comprising compounds that facilitate or mimic the actions of acetylcholine, serotonin, or catecholamines, such as carbachol, or by subjecting the in vitro neuronal sample to electrical stimulation parameters.

摘要翻译： 这涉及通过在候选样品引入体外神经元组织样品之前和之后检测细胞外电压的振荡以及用于实施该方法的装置来检测体外神经元组织样品中精神活性化合物的方法。 细胞外电压参数的分析导致候选样品中存在精神活性物质的迹象以及关于其药理活性和/或组成的信息。 此外，它涉及启动和维持体外样品中重复性神经元活性的存在的过程。 另外，这包括通过引入促进或模拟乙酰胆碱，5-羟色胺或儿茶酚胺的作用的刺激性组合物刺激或起始体外神经元组织样品中的重复性神经元活动（例如EEG）的方法， 作为卡巴胆碱，或通过使体外神经元样品经受电刺激参数。