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    Irradiation of red blood cells and anaerobic storage
    1.
    发明授权
    Irradiation of red blood cells and anaerobic storage 有权

    公开(公告)号：US10136635B2

    公开(公告)日：2018-11-27

    申请号：US13289722

    申请日：2011-11-04

    申请人： Tatsuro Yoshida ,  Paul J. Vernucci

    发明人： Tatsuro Yoshida ,  Paul J. Vernucci

    IPC分类号： A61B19/00 ,  A01N1/02 ,  A61J1/10 ,  A61L2/08

    摘要： A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.

    Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
    2.
    发明授权
    Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device 有权
    综合白细胞，氧气和/或二氧化碳耗竭以及血浆分离过滤装置

    公开(公告)号：US09005343B2

    公开(公告)日：2015-04-14

    申请号：US13572412

    申请日：2012-08-10

    申请人： Tatsuro Yoshida ,  Paul J. Vernucci

    发明人： Tatsuro Yoshida ,  Paul J. Vernucci

    IPC分类号： B01D53/22 ,  B01D19/00 ,  B01D61/00 ,  A61M1/36 ,  A61M1/02

    CPC分类号： B01D19/0031 ,  A61M1/0209 ,  A61M1/0213 ,  A61M1/0218 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/262 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/38 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0439 ,  B01D61/147

    摘要： A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.

    摘要翻译： 一种血液过滤装置，包括：壳体，包括外壁和第一入口，第一出口和第二出口; 能够从血液中分离血浆的膜，其中所述膜形成内腔; 设置有白细胞和氧和/或二氧化碳耗尽介质，其中所述内室，所述白细胞和氧和/或二氧化碳消耗介质能够从血液中消耗白细胞和氧和/或二氧化碳; 设置在外壁和膜之间的外室，其中渗透通过膜的等离子体进入外室并经由第一出口离开过滤器装置; 由此已经耗尽氧气和/或二氧化碳，白细胞和等离子体的血液经由第二出口存在并过滤装置。

    Leukocyte reduction filtration media
    7.
    发明授权
    Leukocyte reduction filtration media 有权
    白细胞还原过滤介质

    公开(公告)号：US06337026B1

    公开(公告)日：2002-01-08

    申请号：US09264276

    申请日：1999-03-08

    申请人： Eric K. Lee ,  Paul J. Vernucci ,  Samuel C. Williams

    发明人： Eric K. Lee ,  Paul J. Vernucci ,  Samuel C. Williams

    IPC分类号： B01D3700

    CPC分类号： B01D39/2024 ,  B01D39/163 ,  B01D39/1661 ,  B01D2239/0216 ,  B01D2239/064 ,  Y10T428/25 ,  Y10T428/254

    摘要： A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.

    摘要翻译： 高容量白细胞消耗过滤介质将高比表面积组分与纤维基质结合，产生过滤介质，其将白细胞除去至少99.99％。 过滤介质使用显着低重量比的高比表面积组分与纤维基质。 高比例区域为白细胞产生大量的粘附位点，而低重量比允许良好的过滤流速。 将过滤介质结合到用于从生物流体中除去白细胞的过滤装置中。

    Core for blood processing apparatus
    9.
    发明授权
    Core for blood processing apparatus 有权
    核心为血液处理设备

    公开(公告)号：US06629919B2

    公开(公告)日：2003-10-07

    申请号：US09764702

    申请日：2001-01-18

    申请人： Yáir Egozy ,  Paul J. Vernucci ,  Lelie E. Rose ,  Etienne Pages

    发明人： Yáir Egozy ,  Paul J. Vernucci ,  Lelie E. Rose ,  Etienne Pages

    IPC分类号： B04B104

    CPC分类号： B04B7/08 ,  B04B5/0442 ,  B04B2005/0464 ,  B04B2005/0478

    摘要： The invention is directed to a centrifugation bowl with a rotating core. The centrifugation bowl includes a rotating bowl body which defines a primary separation chamber. The core, which is generally cylindrically shaped and is disposed within the bowl body, defines a secondary separation chamber. A stationary header assembly may be mounted on top of the bowl body through a rotating seal. The stationary header assembly includes an inlet port for receiving whole blood and an outlet port from which one or more blood components are withdrawn. The inlet port is in fluid communication with a feed tube that extends into the primary separation chamber. The outlet port is in fluid communication with an effluent tube that extends into the bowl body. The effluent tube includes an entryway at a first radial position relative to a central, rotating axis of the bowl. The core is arranged at a second radial position that is outboard from the entryway to the effluent tube and includes one or more core passageways for providing fluid communication between the primary and secondary separation chambers. A sealed region is formed at the upper edge of the core relative to its attachment point to the bowl body. Also provided is a method for recovering a whole blood fraction from a donor using the core of the present invention.

    摘要翻译： 本发明涉及具有旋转芯的离心碗。 离心碗包括限定一次分离室的旋转碗体。 通常为圆柱形且设置在碗体内的芯部限定了二次分离室。 固定的头部组件可以通过旋转的密封件安装在碗体的顶部上。 固定头部组件包括用于接收全血的入口和一个或多个血液成分被从其中排出的出口。 入口与进入主分离室的进料管流体连通。 出口端口与延伸到碗体内的流出物管道流体连通。 流出管包括相对于碗的中心旋转轴线的第一径向位置处的入口。 芯部布置在第二径向位置，该第二径向位置从出入口管的入口处外侧，并且包括一个或多个用于在初级分离室和第二分离室之间提供流体连通的芯通道。 在芯的上边缘处相对于其与碗体的附接点形成密封区域。 还提供了使用本发明的核心从供体中回收全血部分的方法。