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    MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE
    2.
    发明申请
    MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE 审中-公开
    具有导管指导的微流控盒

    公开(公告)号：US20160016170A1

    公开(公告)日：2016-01-21

    申请号：US14335027

    申请日：2014-07-18

    Applicant: Tecan Trading AG

    Inventor： Tiffany LAY ,  Daniel HOFFMEYER ,  Anne R. KOPF-SILL

    IPC: B01L3/00 ,  G01N1/10

    CPC classification number: B01L3/502792 ,  B01L3/0275 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2400/0427

    Abstract: A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.

    Abstract translation: 一种被配置为数字微流体系统的一次性盒，用于在具有盒容纳位置的液体部分中操作样品，并且控制中央控制单元，用于控制位于该位置处的电极阵列的各个电极的选择，并且为多个电极提供用于操纵的各个电压脉冲 液体部分通过电润湿。 所述筒具有疏水性工作表面和具有第二疏水性表面的刚性盖，所述疏水性表面彼此相对并且在平行的平面上被间隔开。 药筒具有多个移液引导件，用于以移液管吸头将液体安全地进入/从间隙排出。 移液引导件中的至少一个提供了通过移液管尖端的相对表面密封地附着的邻接表面，该移液管尖端位于移动孔口处，该移液孔口通过刚性覆盖物，并且构造成防止移液管尖端接触疏水性工作表面。

    COVER WITH MICRO-CONTAINER INTERFACE FOR COVERING A MICROFLUIDIC GAP
    3.
    发明申请
    COVER WITH MICRO-CONTAINER INTERFACE FOR COVERING A MICROFLUIDIC GAP 审中-公开
    覆盖微型容器接口，覆盖微流感差距

    公开(公告)号：US20160082437A1

    公开(公告)日：2016-03-24

    申请号：US14943520

    申请日：2015-11-17

    Applicant: TECAN TRADING AG

    Inventor： Thomas PERROUD ,  Daniel HOFFMEYER ,  Adrian SAGER ,  Anne KOPF-SILL

    IPC: B01L3/00

    CPC classification number: B01L3/502792 ,  B01L3/0275 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/041 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2300/165 ,  B01L2400/0427 ,  B01L2400/0478 ,  G01N2001/1056

    Abstract: A cover (10) for use in a digital microfluidics system (16) for manipulating samples in liquid portions or droplets. The digital microfluidics system (16) includes a first substrate (18) with an array of electrodes (24) and a central control unit (20) for controlling the selection and for providing a number of the electrodes with voltage for manipulating liquid portions or droplets by electrowetting. A working gap (30) with a gap height is located parallel to the array of electrodes (24) and in-between first and second hydrophobic surfaces (26,28) that face each other at least during operation of the digital microfluidics system (16).

    Abstract translation: 一种用于数字微流体系统（16）中的用于操纵液体部分或液滴中的样品的盖（10）。 数字微流体系统（16）包括具有电极阵列（24）和中央控制单元（20）的第一衬底（18），用于控制选择并为多个电极提供用于操纵液体部分或液滴的电压 通过电润湿。 具有间隙高度的工作间隙（30）至少在数字微流体系统（16）的操作期间平行于电极阵列（24）并且位于彼此面对的第一和第二疏水表面（26,28）之间 ）。

    MAGNETIC CONDUITS IN MICROFLUIDICS
    4.
    发明申请
    MAGNETIC CONDUITS IN MICROFLUIDICS 有权

    公开(公告)号：US20210402401A1

    公开(公告)日：2021-12-30

    申请号：US17469656

    申请日：2021-09-08

    Applicant: TECAN TRADING AG

    Inventor： Thomas PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

    IPC: B01L3/00

    Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

    BEAD SEPARATION IN MICROFLUIDICS
    5.
    发明申请
    BEAD SEPARATION IN MICROFLUIDICS 审中-公开

    公开(公告)号：US20180339923A1

    公开(公告)日：2018-11-29

    申请号：US15756209

    申请日：2016-09-01

    Applicant: TECAN TRADING AG

    Inventor： Thomas PERROUD ,  Dan TRAN ,  Daniel HOFFMEYER ,  Tiffany LAY ,  Manjeet DHINDSA

    IPC: C02F1/48

    Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.

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