公开(公告)号：US20230167073A1

公开(公告)日：2023-06-01

申请号：US17919186

申请日：2021-04-15

申请人： Teijin Pharma Limited

发明人： Sakae SUGIYAMA ,  Takuya YOKOSAKA ,  Kunio MINAMIZONO ,  Asahi KAWANA ,  Toshiyuki KANEKO ,  Akinobu MARUYAMA ,  Kosuke SASAKI ,  Shinnosuke HOSODA ,  Masaki KOSHIMIZU ,  Susumu TAKEUCHI ,  Kenta KATO ,  Nagasree CHAKKA ,  Brett M. JOHNSON ,  Ryan D. WHITE ,  Wei ZHAO

IPC分类号： C07D239/42 ,  C07D239/48 ,  C07D491/107 ,  C07D487/12 ,  C07D239/47 ,  C07D401/04 ,  C07D239/34 ,  C07D487/04 ,  C07D417/04 ,  C07D413/04 ,  C07D409/04 ,  C07D239/52 ,  C07D237/22 ,  C07D237/14 ,  C07D417/12 ,  C07D409/12 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/14 ,  C07D231/20 ,  C07D213/30 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/08 ,  C07D491/052

CPC分类号： C07D239/42 ,  C07D239/48 ,  C07D491/107 ,  C07D487/12 ,  C07D239/47 ,  C07D401/04 ,  C07D239/34 ,  C07D487/04 ,  C07D417/04 ,  C07D413/04 ,  C07D409/04 ,  C07D239/52 ,  C07D237/22 ,  C07D237/14 ,  C07D417/12 ,  C07D409/12 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/14 ,  C07D231/20 ,  C07D213/30 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/08 ,  C07D491/052

摘要： A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar1, Ar2, X1-X3, R1, R3, R7, R8, L1, and L2 are as defined in the specifications.)

公开(公告)号：US20220204477A1

公开(公告)日：2022-06-30

申请号：US17602028

申请日：2020-04-10

申请人： Teijin Pharma Limited

发明人： Nagasree CHAKKA ,  Hua GAO ,  Angel GUZMAN-PEREZ ,  Brett Michael JOHNSON ,  Madeleine KIEFFER ,  Justin MALINOWSKI ,  Laurie SCHENKEL

IPC分类号： C07D401/14

摘要： The present invention provides compounds which inhibit the activity of TRPC6, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.