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公开(公告)号：US20100047827A1
公开(公告)日：2010-02-25
申请号：US12522858
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Ulla Impola , Olli Aitio , Leena Valmu , Suvi Natunen , Hanna Salo
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Ulla Impola , Olli Aitio , Leena Valmu , Suvi Natunen , Hanna Salo
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/44 , G01N33/56966 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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2.发明申请Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof 审中-公开来自人类细胞的新型碳水化合物组成及其分析和修饰方法公开(公告)号：US20090162938A1
公开(公告)日：2009-06-25
申请号：US12084626
申请日：2006-11-08
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola
CPC分类号： G01N33/5073 , G01N2400/12 , G01N2400/38
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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公开(公告)号：US08759005B2
公开(公告)日：2014-06-24
申请号：US11988563
申请日：2006-07-11
申请人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen
发明人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C08B37/00 , G01N2400/12 , G01N2400/38
摘要： The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and fractionated tissue parts, or artificial models of tissues such as cultivated cell lines. The invention is further directed to the compositions and compositions produced by the methods according to the invention. The invention further represent methods for analysis of the glycomes, especially mass spectrometric methods.
摘要翻译： 本发明揭示了用于从动物组织制备新型碳水化合物组合物，糖尿病的新方法。 组织基质材料可以是总组织样品和分级组织部分，或人造模型的组织如培养细胞系。 本发明还涉及通过根据本发明的方法制备的组合物和组合物。 本发明还描述了用于分析糖尿病的方法，特别是质谱方法。
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公开(公告)号：US20100003699A1
公开(公告)日：2010-01-07
申请号：US12355532
申请日：2009-01-16
申请人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen
发明人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen
CPC分类号： G01N33/6848 , G01N33/574 , G01N2400/00
摘要： The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and fractionated tissue parts, or artificial models of tissues such as cultivated cell lines. The invention is further directed to the compositions and compositions produced by the methods according to the invention. The invention further represent methods for analysis of the glycomes, especially mass spectrometric methods.
摘要翻译： 本发明揭示了用于从动物组织制备新型碳水化合物组合物，糖尿病的新方法。 组织基质材料可以是总组织样品和分级组织部分，或人造模型的组织如培养细胞系。 本发明还涉及通过根据本发明的方法制备的组合物和组合物。 本发明还描述了用于分析糖尿病的方法，特别是质谱方法。
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公开(公告)号：US20090104603A1
公开(公告)日：2009-04-23
申请号：US11988563
申请日：2006-07-11
申请人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen
发明人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen
CPC分类号： G01N33/5308 , C08B37/00 , G01N2400/12 , G01N2400/38
摘要： The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and fractionated tissue parts, or artificial models of tissues such as cultivated cell lines. The invention is further directed to the compositions and compositions produced by the methods according to the invention. The invention further represent methods for analysis of the glycomes, especially mass spectrometric methods.
摘要翻译： 本发明揭示了用于从动物组织制备新型碳水化合物组合物，糖尿病的新方法。 组织基质材料可以是总组织样品和分级组织部分，或人造模型的组织如培养细胞系。 本发明还涉及通过根据本发明的方法制备的组合物和组合物。 本发明还描述了用于分析糖尿病的方法，特别是质谱方法。
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6.发明授权Carbohydrate profile compositions from human cells and methods for analysis and modification thereof 有权来自人细胞的碳水化合物曲线组合物及其分析和修饰方法公开(公告)号：US08691774B2
公开(公告)日：2014-04-08
申请号：US11988564
申请日：2006-07-11
申请人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
发明人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
IPC分类号： G01N33/577 , G01N33/574
CPC分类号： C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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7.发明申请Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof 有权来自人类细胞的新型碳水化合物组成及其分析和修饰方法公开(公告)号：US20100055710A1
公开(公告)日：2010-03-04
申请号：US11988564
申请日：2006-07-11
申请人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
发明人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
CPC分类号： C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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8.发明申请NOVEL CARBOHYDRATE FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开来自人类细胞的新型碳水化合物及其分析和改性方法公开(公告)号：US20100028913A1
公开(公告)日：2010-02-04
申请号：US12523586
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
IPC分类号： G01N33/569 , G01N33/53 , G01N33/577
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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公开(公告)号：US20100068806A1
公开(公告)日：2010-03-18
申请号：US12522801
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Tiitiene , Ulla Impola , Milla Mikkola , Leena Valmu , Minna Tiittanen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Tiitiene , Ulla Impola , Milla Mikkola , Leena Valmu , Minna Tiittanen
IPC分类号： C12N5/0735 , C12N5/0775 , C07H21/04 , C07K14/42
CPC分类号： C12N5/0606 , C12N5/0647 , C12N5/0663 , C12N5/0665 , C12N2501/59 , C12N2501/90
摘要： The present invention provides methods and materials to modulate and grow stem cells by contacting stem cells with a binder recognizing terminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also useful to screen such a binding agents and binders.
摘要翻译： 本发明提供了通过使干细胞与识别干细胞的末端聚糖结构的粘合剂接触来调节和培养干细胞的方法和材料。 调制可以是形态变化，分化状态的变化，生物状态或依从性。 本发明提供的材料也可用于筛选这种粘合剂和粘合剂。
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公开(公告)号：US20090324617A1
公开(公告)日：2009-12-31
申请号：US12320297
申请日：2009-01-22
申请人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Anne Olonen , Noora Salovuori , Juhani Saarinen , Jari Helin
发明人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Anne Olonen , Noora Salovuori , Juhani Saarinen , Jari Helin
CPC分类号： G01N33/574 , A61K39/0011 , A61K2039/505 , C07K16/3076 , G01N33/57469 , G01N2400/00
摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.
摘要翻译： 本发明描述了由某些癌细胞，肿瘤和其他恶性组织特异性表达的聚糖。 本发明描述了检测癌症特异性聚糖的方法以及生产结合所述聚糖的试剂的方法。 本发明还涉及所述聚糖和与其结合的试剂用于癌症和恶性肿瘤的诊断的用途。 此外，本发明涉及使用所述聚糖和与其结合的试剂来治疗癌症和恶性肿瘤。 此外，本发明包括通过分析聚糖结构来区分恶性和良性肿瘤的有效方法。
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