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    FLUORESCENT PROBE SPECIFIC TO HYDROGEN PEROXIDE
    1.
    发明申请
    FLUORESCENT PROBE SPECIFIC TO HYDROGEN PEROXIDE 有权
    荧光探针特异性过氧化氢

    公开(公告)号：US20110159603A1

    公开(公告)日：2011-06-30

    申请号：US12920684

    申请日：2009-03-04

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Masahiro Abo

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Masahiro Abo

    IPC分类号： G01N33/00 ,  C07D311/82

    CPC分类号： C07D311/82 ,  G01N31/22 ,  G01N2021/7786 ,  Y10T436/206664

    摘要： A compound represented by the following general formula (IA) or (IB) (R1 represents an electron withdrawing substituent, R2 and R3 represent a hydrogen atom or a halogen atom; R4 and R3 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R6 represents a hydrogen atom or an alkyl group) or a salt thereof, and a reagent for measuring hydrogen peroxide comprising the compound or a salt thereof.

    摘要翻译： 由以下通式（IA）或（IB）表示的化合物（R1表示吸电子取代基，R2和R3表示氢原子或卤素原子; R4和R3表示氢原子，烷基羰基或烷基羰氧基甲基 基团，R6表示氢原子或烷基）或其盐，以及含有该化合物或其盐的测量过氧化氢的试剂。

    Fluorescent probe specific to hydrogen peroxide
    2.
    发明授权
    Fluorescent probe specific to hydrogen peroxide 有权
    荧光探针特异于过氧化氢

    公开(公告)号：US08394850B2

    公开(公告)日：2013-03-12

    申请号：US12920684

    申请日：2009-03-04

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Masahiro Abo

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Masahiro Abo

    IPC分类号： A61K31/352 ,  C07D311/82

    CPC分类号： C07D311/82 ,  G01N31/22 ,  G01N2021/7786 ,  Y10T436/206664

    摘要： A compound represented by the following general formula (IA) or (IB) (R1 represents an electron withdrawing substituent, R2 and R3 represent a hydrogen atom or a halogen atom; R4 and R3 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R6 represents a hydrogen atom or an alkyl group) or a salt thereof, and a reagent for measuring hydrogen peroxide comprising the compound or a salt thereof.

    摘要翻译： 由以下通式（IA）或（IB）表示的化合物（R1表示吸电子取代基，R2和R3表示氢原子或卤素原子; R4和R3表示氢原子，烷基羰基或烷基羰氧基甲基 基团，R6表示氢原子或烷基）或其盐，以及含有该化合物或其盐的测量过氧化氢的试剂。

    Reagent for measuring active nitrogen
    4.
    发明授权
    Reagent for measuring active nitrogen 有权
    用于测量活性氮的试剂

    公开(公告)号：US08895317B2

    公开(公告)日：2014-11-25

    申请号：US13131173

    申请日：2009-12-04

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Saki Izumi

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Saki Izumi

    IPC分类号： G01N33/48 ,  C07D311/82 ,  G01N31/22

    CPC分类号： G01N31/22 ,  Y10T436/170769 ,  Y10T436/173076 ,  Y10T436/177692 ,  Y10T436/178459 ,  Y10T436/179228

    摘要： A compound represented by the general formula (I) [R1 and R2 are amino groups that substitute at adjacent positions on the benzene ring; R3 and R4 are halogen atoms; R5 and R6 represent hydrogen atom, an acyl group or an acyloxy(C1-6 alkyl) group; R7 and R8 represent —(CH2)p—N(R9)(R10) (p is 1 to 4, and R9 and R10 represent —(CH2)n—COOH (n is 1 to 4))], which is useful for measuring a reactive nitrogen species existing in cells such as nitrogen monoxide or peroxynitrite at high sensitivity over a long period of time.

    摘要翻译： 由通式（I）表示的化合物[R1和R2是在苯环上的相邻位置取代的氨基; R3和R4是卤素原子; R5和R6代表氢原子，酰基或酰氧基（C1-6烷基）基团; R7和R8表示 - （CH2）p-N（R9）（R10）（p为1至4，R9和R10表示 - （CH2）n-COOH（n为1至4））] 在长时间内以高灵敏度测量存在于细胞中的活性氮物质，例如一氧化氮或过氧亚硝酸盐。

    Fluorescent probe for measurement of UDP-glucuronosyltransferase
    7.
    发明授权
    Fluorescent probe for measurement of UDP-glucuronosyltransferase 有权
    用于测量UDP-葡糖醛酸基转移酶的荧光探针

    公开(公告)号：US08309319B2

    公开(公告)日：2012-11-13

    申请号：US12527793

    申请日：2008-02-26

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Rie Tomiyasu

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Rie Tomiyasu

    IPC分类号： C12Q1/48

    CPC分类号： G01N33/582 ,  C12Q1/48

    摘要： A fluorescent probe for measurement of UDP-glucuronosyltransferase, which comprises a fluorescein derivative, wherein in the fluorescein derivative, the 2-carboxy group on the benzene ring of fluorescein is replaced with another monovalent substituent, provided that said substituent is a substituent other than sulfo group, and the substituent does not have carboxy group or sulfo group, and wherein the fluorescein derivative may have an arbitrary substituent at a position on the benzene ring other than the 2-position, and the fluorescein derivative may have a substituent selected from the group consisting of an alkoxy group and a halogen atom at the 2-position and/or the 7-position of fluorescein.

    摘要翻译： 用于测量UDP-葡糖醛酸基转移酶的荧光探针，其包含荧光素衍生物，其中在荧光素衍生物中，荧光素的苯环上的2-羧基被另外的一价取代基取代，条件是所述取代基是除磺基以外的取代基 并且取代基不具有羧基或磺基，并且其中所述荧光素衍生物在除2-位之外的苯环上的位置可以具有任意的取代基，并且所述荧光素衍生物可以具有选自下列基团的取代基 由荧光素的2-位和/或7-位上的烷氧基和卤素原子组成。

    Coumarin derivative
    8.
    发明授权
    Coumarin derivative 失效
    香豆素衍生物

    公开(公告)号：US07482473B2

    公开(公告)日：2009-01-27

    申请号：US11470820

    申请日：2006-09-07

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Takuji Shoda

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Takuji Shoda

    IPC分类号： C07D405/00

    CPC分类号： C07D405/12 ,  C07D405/14

    摘要： A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence only after reacting with a thiol group.

    摘要翻译： 由以下通式（I）表示的化合物或其盐[R1表示氢原子或C1-12烷基; R2表示具有一个或多个马来酰亚胺基团的C1-12烷基，具有两个或更多个马来酰亚胺基团的芳基，由式（A）表示的基团： - （CH 2）n -CO-N（R 11）（R 12） （R11和R12表示氢原子，C1-12烷基，具有一个或多个马来酰亚胺基的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基，n表示1至6的整数）， 或由式（B）表示的基团： - （CH 2）m -NH-CO-R 13（R 13表示具有一个或多个马来酰亚胺基团的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基， m表示1〜6的整数）; R3和R5代表氢原子或卤原子; R 4表示羟基，C 1-12酰氧基，C 1-12酰氧基甲氧基或氨基]，其仅在与硫醇基反应后具有发射强荧光性质的新型荧光标记剂是有用的。

    ACIDIC ENVIRONMENT-DETECTING FLUORESCENT PROBE
    10.
    发明申请
    ACIDIC ENVIRONMENT-DETECTING FLUORESCENT PROBE 有权
    酸性环境检测荧光探针

    公开(公告)号：US20140248654A1

    公开(公告)日：2014-09-04

    申请号：US14343033

    申请日：2012-09-06

    申请人： Yasuteru Urano ,  Tetsuo Nagano ,  Daisuke Asanuma ,  Kenzo Hirose ,  Shigeyuki Namiki ,  Yousuke Takaoka

    发明人： Yasuteru Urano ,  Tetsuo Nagano ,  Daisuke Asanuma ,  Kenzo Hirose ,  Shigeyuki Namiki ,  Yousuke Takaoka

    IPC分类号： G01N33/52

    CPC分类号： G01N33/52 ,  C07D311/82 ,  C07D405/04 ,  C07D405/14 ,  C09B11/24 ,  C09B69/00 ,  C09B69/103 ,  C09K11/06 ,  C09K2211/1044 ,  C09K2211/1088 ,  G01N21/6428 ,  G01N33/5005

    摘要： Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. In the formula, R1 and R2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R1 and/or R2 represents an alkyl group which may be substituted); R3, R4, R5, R6, R7 and R8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.

    摘要翻译： 提供由式（I）表示的化合物，其可以用作仅在细胞内酸性环境中变得高度荧光的荧光探针，并且可以适用于作为微结构的细胞内小泡的荧光成像。 在该式中，R 1和R 2独立地表示氢原子或可被取代的烷基（其中R 1和/或R 2表示可被取代的烷基）; R 3，R 4，R 5，R 6，R 7和R 8独立地表示氢原子，卤素原子等; X表示可以引入标记位点或靶标积累位点的官能团等; Y表示卤原子，可被取代的烷基等; m表示0〜5的整数， n表示0〜5的整数。