公开(公告)号：US20100138943A1

公开(公告)日：2010-06-03

申请号：US12621235

申请日：2009-11-18

申请人： Tetsuro Miki ,  Yasuharu Tabara ,  Katsuhiko Kohara ,  Jun Nakura ,  Satoshi Umemura ,  Nobuhito Hirawa ,  Hirotsugu Ueshima ,  Yoshikuni Kita ,  Yasuyuki Nakamura

发明人： Tetsuro Miki ,  Yasuharu Tabara ,  Katsuhiko Kohara ,  Jun Nakura ,  Satoshi Umemura ,  Nobuhito Hirawa ,  Hirotsugu Ueshima ,  Yoshikuni Kita ,  Yasuyuki Nakamura

IPC分类号： A01K67/00 ,  C07H21/04 ,  C12Q1/68 ,  C40B40/08 ,  C12N15/63

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0375 ,  C12N9/14 ,  C12N15/8509 ,  C12N2800/30 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A genetic marker including a SNP which can be used for assessing the risk of developing hypertension, a polynucleotide for assessing the risk of developing hypertension which can be used as a primer or probe for detecting the genetic marker, a method for assessing the risk of developing hypertension using the SNP, a microarray for assessing the risk of developing hypertension which is used for genotyping of the SNP, a kit used in the method for assessing the risk of developing hypertension, and the like.

摘要翻译： 包括可用于评估发生高血压风险的SNP的遗传标记，用于评估可用作检测遗传标记的引物或探针的发展中的高血压风险的多核苷酸，评估发展风险的方法 使用SNP的高血压，用于评估用于SNP基因分型的高血压发生风险的微阵列，用于评估发生高血压的风险的方法的试剂盒等。

公开(公告)号：US20100229249A1

公开(公告)日：2010-09-09

申请号：US12600223

申请日：2009-02-20

申请人： Tetsuro Miki ,  Yasuharu Tabara ,  Katsuhiko Kohara ,  Jun Nakura ,  Satoshi Umemura ,  Nobuhito Hirawa ,  Hirotsugu Ueshima ,  Yoshikuni Kita ,  Yasuyuki Nakamura

发明人： Tetsuro Miki ,  Yasuharu Tabara ,  Katsuhiko Kohara ,  Jun Nakura ,  Satoshi Umemura ,  Nobuhito Hirawa ,  Hirotsugu Ueshima ,  Yoshikuni Kita ,  Yasuyuki Nakamura

IPC分类号： A01K67/00 ,  C07H21/04 ,  C12Q1/68 ,  C40B40/06 ,  C12N15/63

CPC分类号： C12N15/8509 ,  C12N2800/30 ,  C12Q1/6883 ,  C12Q2600/156

摘要： Provided in the present invention is a genetic marker including a SNP which can be used for assessing the risk of developing hypertension, a polynucleotide for assessing the risk of developing hypertension which can be used as a primer or probe for detecting the genetic marker, a method for assessing the risk of developing hypertension using the SNP, a microarray for assessing the risk of developing hypertension which is used for genotyping of the SNP, a kit used in the method for assessing the risk of developing hypertension, and the like.

摘要翻译： 本发明提供了包括可用于评估发生高血压风险的SNP的遗传标记，用于评估可用作检测遗传标记的引物或探针的发生高血压的风险的多核苷酸，方法 用于评估使用SNP发生高血压的风险，用于评估用于SNP基因分型的高血压发生风险的微阵列，用于评估发生高血压风险的方法的试剂盒等。

公开(公告)号：US07109044B1

公开(公告)日：2006-09-19

申请号：US09786503

申请日：1999-04-09

申请人： Hiroshi Oda ,  Kosuke Seiki ,  Hiroshi Nakajima ,  Nobuyuki Sato ,  Yoshihiro Urade ,  Nobuhito Hirawa ,  Yoshio Uehara

发明人： Hiroshi Oda ,  Kosuke Seiki ,  Hiroshi Nakajima ,  Nobuyuki Sato ,  Yoshihiro Urade ,  Nobuhito Hirawa ,  Yoshio Uehara

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/573 ,  G01N33/70 ,  G01N33/88 ,  G01N2800/347 ,  Y10S436/811

摘要： The present invention relates to a method of detection of an early-stage renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and comparing the determined concentration with a reference value set by determining the concentrations of human lipocalin-type prostaglandin D synthase in body fluid samples taken from healthy subjects; and a method of disease state management for a renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and evaluating the glomerular filtration ability of the subject from the determined concentration.

摘要翻译： 本发明涉及一种早期肾病的检测方法，包括测定取自受试者的体液样品中人脂笼蛋白型前列腺素D合成酶的浓度，并将测定的浓度与通过确定 来自健康受试者的体液样品中人脂笼蛋白型前列腺素D合成酶的浓度; 以及肾病疾病状态管理方法，包括测定取自对象的体液样品中人脂质运载蛋白型前列腺素D合成酶的浓度，并根据测定的浓度评价受试者的肾小球滤过能力。