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1.发明申请COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF 审中-公开用于诱导细胞增殖和分化的化合物及其使用方法公开(公告)号：US20160031837A1
公开(公告)日：2016-02-04
申请号：US14772284
申请日：2014-03-14
发明人： Sangeeta Bhatia , Jing Shan , Michelle Palmer , Nathan Ross
IPC分类号： C07D263/24 , A61K31/4174 , A61K31/4409 , C07D213/75 , A01K67/027 , C07D209/88 , A61K31/137 , C07C211/32 , A61K31/4035 , C07D209/48 , A61K35/407 , A61K31/403
CPC分类号： C07D263/24 , A01K67/0278 , A01K2227/105 , A01K2267/0331 , A61K31/137 , A61K31/403 , A61K31/4035 , A61K31/4174 , A61K31/4409 , A61K35/407 , C07C211/32 , C07D209/48 , C07D209/88 , C07D213/75 , C12N5/067 , C12N2501/02 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/237 , C12N2501/999 , C12N2503/02 , C12N2506/45 , C12N2533/90 , Y02A50/387 , Y02A50/463
摘要： The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.
摘要翻译： 本发明提供诱导和/或分化细胞增殖的方法，包括在本发明的方法中使细胞与化合物接触。 本发明还提供可通过本发明的方法获得的细胞。 肝病影响全球5亿多人。 器官移植是治疗肝衰竭的黄金标准，但器官短缺是急性的。
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公开(公告)号：US20210047617A1
公开(公告)日：2021-02-18
申请号：US17004970
申请日：2020-08-27
发明人： Sangeeta Bhatia , Jing Shan , Anne Carpenter Van Dyk , David Logan , Nathan Ross
摘要： The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.
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3.发明授权公开(公告)号：US10081609B2
公开(公告)日：2018-09-25
申请号：US14772284
申请日：2014-03-14
发明人： Sangeeta Bhatia , Jing Shan , Michelle Palmer , Nathan Ross
IPC分类号： C12N5/00 , C07D263/24 , C12N5/071 , A01K67/027 , A61K31/137 , A61K31/403 , A61K31/4035 , A61K31/4174 , A61K31/4409 , A61K35/407 , C07C211/32 , C07D209/48 , C07D209/88 , C07D213/75
CPC分类号： C07D263/24 , A01K67/0278 , A01K2227/105 , A01K2267/0331 , A61K31/137 , A61K31/403 , A61K31/4035 , A61K31/4174 , A61K31/4409 , A61K35/407 , C07C211/32 , C07D209/48 , C07D209/88 , C07D213/75 , C12N5/067 , C12N2501/02 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/237 , C12N2501/999 , C12N2503/02 , C12N2506/45 , C12N2533/90 , Y02A50/387 , Y02A50/463
摘要： The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.
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公开(公告)号：US11788063B2
公开(公告)日：2023-10-17
申请号：US17004970
申请日：2020-08-27
发明人： Sangeeta Bhatia , Jing Shan , Anne Carpenter Van Dyk , David Logan , Nathan Ross
CPC分类号： C12N5/067 , C12Q1/04 , C12N2502/1323 , C12N2531/00
摘要： The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.
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5.发明授权公开(公告)号：US11629132B2
公开(公告)日：2023-04-18
申请号：US16135468
申请日：2018-09-19
发明人： Sangeeta Bhatia , Jing Shan , Michelle Palmer , Nathan Ross
IPC分类号： C12N5/071 , C07D263/24 , C12N5/07 , A61K35/12 , A01K67/027 , A61K31/137 , A61K31/403 , A61K31/4035 , A61K31/4174 , A61K31/4409 , A61K35/407 , C07C211/32 , C07D209/48 , C07D209/88 , C07D213/75
摘要： The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention.
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公开(公告)号：US10801015B2
公开(公告)日：2020-10-13
申请号：US14772210
申请日：2014-03-14
发明人： Sangeeta Bhatia , Jing Shan , Anne Carpenter Van Dyk , David Logan , Nathan Ross
摘要： The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.
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公开(公告)号：US20160017283A1
公开(公告)日：2016-01-21
申请号：US14772210
申请日：2014-03-14
发明人： Sangeeta Bhatia , Jing Shan , Anne Carpenter , David Logan , Nathan Ross
CPC分类号： C12N5/067 , C12N2502/1323 , C12N2531/00 , C12Q1/04
摘要： The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the discovery that compositions and methods for primary cells in a high-throughput co-culture platform, image analysis for distinguishing cells in co-cultures and assays that are suitable for screening of agents in epithelial cells, such as hepatocytes.
摘要翻译： 本发明的特征在于共同培养原代细胞同时保持对原代细胞特异性的关键生物活性。 本发明至少部分地基于以下发现：高通量共培养平台中原代细胞的组合物和方法，用于区分共培养物中的细胞的图像分析和适于筛选上皮中的试剂的测定 细胞，如肝细胞。
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