公开(公告)号：US20180200367A1

公开(公告)日：2018-07-19

申请号：US15742684

申请日：2016-07-08

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Susan Lee ,  Kimberly A. Noonan ,  Drew M. Pardoll

IPC: A61K39/395 ,  C07K14/47 ,  C07K14/725 ,  C07K14/705

CPC classification number: A61K39/39558 ,  A61K35/17 ,  C07K14/4748 ,  C07K14/7051 ,  C07K14/70521 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C12N5/0635 ,  C12N5/0636 ,  C12N2510/00

Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.

公开(公告)号：US20170224691A1

公开(公告)日：2017-08-10

申请号：US15269305

申请日：2016-09-19

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Paolo Serafini ,  Kimberly A. Noonan ,  Vincenzo Bronte

IPC: A61K31/53 ,  G01N33/50 ,  A61K31/519 ,  A61K31/4985 ,  A61K45/06 ,  A61K39/00

CPC classification number: A61K31/53 ,  A61K31/4985 ,  A61K31/519 ,  A61K39/0011 ,  A61K45/06 ,  G01N33/5091 ,  G01N2800/52 ,  A61K2300/00

Abstract: The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject.

公开(公告)号：US20230016031A1

公开(公告)日：2023-01-19

申请号：US17945729

申请日：2022-09-15

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Kimberly A. Noonan ,  Drew M. Pardoll ,  Valentina Hoyos Velez

IPC: A61K39/395 ,  C07K14/725 ,  C07K14/705 ,  C07K14/47 ,  A61K35/17 ,  C12N5/0781 ,  C12N5/0783

Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.

公开(公告)号：US20190298768A1

公开(公告)日：2019-10-03

申请号：US16207864

申请日：2018-12-03

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Kimberly A. Noonan

IPC: A61K35/17 ,  C12N5/077 ,  C12N5/0783 ,  A61P35/00

Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.

公开(公告)号：US10406178B2

公开(公告)日：2019-09-10

申请号：US15606766

申请日：2017-05-26

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Kimberly A. Noonan

IPC: A61K35/17 ,  C12N5/0783 ,  C12N5/077 ,  A61P35/00 ,  A61K35/12

Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.

公开(公告)号：US20150320798A1

公开(公告)日：2015-11-12

申请号：US14647358

申请日：2013-11-26

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Kimberly A. Noonan ,  Leonido Luznik

IPC: A61K35/17 ,  A61K31/675

CPC classification number: A61K35/17 ,  A61K31/675 ,  A61K35/28 ,  A61K35/51 ,  A61K39/0011 ,  A61K2039/5158

Abstract: The present invention relates to the field of cancer therapy. More specifically, the present invention provides methods and compositions useful for augmenting anti-tumor immunity. In one embodiment, a method for treating or preventing post-allogeneic transplant relapse in a subject who has received post-transplant cyclophosphamide treatment comprises the steps of (a) obtaining a bone marrow sample from the subject; (b) expanding the marrow infiltrating lymphocytes (MILs) present in the sample; and (c) administering the MILs to the subject. In a specific embodiment, the method significantly reduces the likelihood of developing GVHD.

Abstract translation: 本发明涉及癌症治疗领域。 更具体地，本发明提供了可用于增强抗肿瘤免疫性的方法和组合物。 在一个实施方案中，用于治疗或预防接受移植后环磷酰胺治疗的受试者的同种异体移植物复发的方法包括以下步骤：（a）从受试者获得骨髓样品; （b）扩大样品中存在的骨髓浸润淋巴细胞（MIL）; 和（c）向受试者施用MIL。 在具体实施方案中，该方法显着降低了发生GVHD的可能性。

公开(公告)号：US20230000919A1

公开(公告)日：2023-01-05

申请号：US17864546

申请日：2022-07-14

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Kimberly A. Noonan

IPC: A61K35/17 ,  A61P35/00 ,  C12N5/0783 ,  C12N5/077

Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.

公开(公告)号：US20180185434A1

公开(公告)日：2018-07-05

申请号：US15740981

申请日：2016-06-29

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Susan Lee ,  Kimberly A. Noonan ,  Drew M. Pardoll

IPC: A61K38/00 ,  A61K38/17 ,  C07K14/725 ,  C07K14/705 ,  C07K19/00 ,  C12N15/62 ,  A61K35/17 ,  A61K48/00 ,  A61P35/02 ,  C12N15/82

CPC classification number: A61K38/005 ,  A61K35/17 ,  A61K38/00 ,  A61K38/17 ,  A61K38/1709 ,  A61K48/005 ,  A61P35/02 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K19/00 ,  C12N15/62 ,  C12N15/8201

Abstract: In some aspects, the embodiments relate to compositions and methods related to chimeric transmembrane proteins. The chimeric transmembrane proteins may comprise the extracellular domain of an inhibitory receptor, and an intracellular signaling domain that can activate an immune response.

公开(公告)号：US09687510B2

公开(公告)日：2017-06-27

申请号：US15112353

申请日：2015-09-04

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Kimberly A. Noonan

IPC: A61K35/26 ,  C12N5/00 ,  A61K35/17 ,  C12N5/0783 ,  C12N5/077 ,  A61K35/12

CPC classification number: A61K35/17 ,  A61K2035/124 ,  A61P35/00 ,  C12N5/0636 ,  C12N5/0669 ,  C12N2500/02 ,  C12N2501/2302 ,  C12N2501/998

Abstract: Various embodiments of the invention relate to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. Some embodiments relate to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. Some embodiments relate to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.

公开(公告)号：US09468643B2

公开(公告)日：2016-10-18

申请号：US14281363

申请日：2014-05-19

Applicant: The Johns Hopkins University

Inventor： Ivan M. Borrello ,  Paolo Serafini ,  Kimberly A. Noonan ,  Vincenzo Bronte

IPC: A61K31/519 ,  A61K31/4985 ,  A61K31/53 ,  A61K45/06

CPC classification number: A61K31/53 ,  A61K31/4985 ,  A61K31/519 ,  A61K39/0011 ,  A61K45/06 ,  G01N33/5091 ,  G01N2800/52 ,  A61K2300/00

Abstract: The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject.

Abstract translation: 本发明的特征在于用于治疗或预防受试者中免疫介导的疾病的PDE5抑制剂的方法和组合物。