公开(公告)号：US20160199463A1

公开(公告)日：2016-07-14

申请号：US14969944

申请日：2015-12-15

申请人： The Johns Hopkins University

发明人： Lewis Romer ,  Deepesh Pandey ,  Dan E. Berkowitz

IPC分类号： A61K38/50 ,  A61K31/519 ,  C12N7/00 ,  C12N15/113 ,  A61K31/522 ,  A61K31/12

CPC分类号： A61K38/50 ,  A61K31/12 ,  A61K31/519 ,  A61K31/522 ,  A61K45/06 ,  A61K48/00 ,  C12N7/00 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12Y305/01098

摘要： The invention features compositions comprising HDAC2 and methods for protecting the vascular endothelium from injury.

摘要翻译： 本发明的特征在于包含HDAC2的组合物和用于保护血管内皮免受损伤的方法。

公开(公告)号：US20210372995A1

公开(公告)日：2021-12-02

申请号：US16758030

申请日：2018-10-22

申请人： The Johns Hopkins University

发明人： Lewis Romer ,  David Gracias ,  Jayson Pagaduan ,  Anil Bhatta ,  Xing Chen ,  Qianru Jin

IPC分类号： G01N33/50 ,  C12N5/077 ,  C12N5/071 ,  B01L3/00

摘要： In one aspect, provided is a composition (biomimetic composition) that includes a biomimetic in vitro model of an arteriolar vessel comprising: at least one of 1) human smooth muscle cells and 2) human pulmonary endothelial cells; wherein the vessel recapitulates one or more of the overall tubular geometry, morphometrics, extracellular matrix constituents, cellular morphology, cellular alignment, and functional heterotypic connections between the human smooth muscle cells and/or the human endothelial cells as compared to an in vivo arteriolar vessel. A microfluidics-based model platform of the pulmonary circulation is provided. Methods of use include measuring flow in biomimetic vessels, and to determine the resistance of these biomimetic vessels in the setting of a variety of experimental conditions that recapitulate the pathobiology of pulmonary hypertension.

公开(公告)号：US20220186055A1

公开(公告)日：2022-06-16

申请号：US17604648

申请日：2020-04-19

申请人： The Johns Hopkins University

发明人： Zhouran Jiang ,  Devina Chatterjee ,  Galip Ozan Erol ,  David H. Gracias ,  Sung Hoon Kang ,  Lewis Romer ,  Narutoshi Hibino

IPC分类号： C09D11/106 ,  C09D11/102 ,  C08L27/18 ,  C08L5/00 ,  B29C64/112 ,  B29C64/209 ,  B29C64/314

摘要： Provided are compositions (which may inks), methods, devices, and systems that are used with 3D printing. The compositions contain fluoropolymer particles, one or more type of a medium, one or more surfactants, and one or more shear thinning agents. The fluoropolymer component can be one or more of polytetrafluoroethylene (PTFE), perfluoroalkoxy, fluorinated ethylene-propylene, and poly ethyl enetetrafluoroethylene. Cartridges that contain the compositions are also provided. Methods of making the compositions, methods of using the compositions for 3D printing, and articles of manufacture, such as medical devices, are also provided.