-
公开(公告)号：US11027007B2
公开(公告)日：2021-06-08
申请号：US16578748
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/115 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US11786591B2
公开(公告)日：2023-10-17
申请号：US17334505
申请日：2021-05-28
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： C07K14/005 , A61K39/155 , A61K39/39 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , A61K48/00 , C07K14/005 , C07K14/135 , C07K2319/70 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US10420834B2
公开(公告)日：2019-09-24
申请号：US15539640
申请日：2015-12-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/005 , A61K39/39 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US20240024458A1
公开(公告)日：2024-01-25
申请号：US18462340
申请日：2023-09-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute For Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US20240101609A1
公开(公告)日：2024-03-28
申请号：US18537448
申请日：2023-12-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , Tongqing Zhou , John Mascola , Kai Xu , Yongping Yang , Paul Thomas , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
-
公开(公告)号：US20200009243A1
公开(公告)日：2020-01-09
申请号：US16578748
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , A61K48/00 , C07K14/005 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US20210283240A1
公开(公告)日：2021-09-16
申请号：US17334505
申请日：2021-05-28
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US20180008697A1
公开(公告)日：2018-01-11
申请号：US15539640
申请日：2015-12-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/135 , A61K39/39 , A61K48/00
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
-
公开(公告)号：US20220002351A1
公开(公告)日：2022-01-06
申请号：US17478533
申请日：2021-09-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter D. Kwong , Barney S. Graham , Jason S. McLellan , Jeffrey Boyington , Lei Chen , Man Chen , Gwo-Yu Chuang , Ivelin Stefanov Georgiev , Jason Gorman , Michael Gordon Joyce , Masaru Kanekiyo , Gilad Ofek , Marie Pancera , Mallika Sastry , Cinque Soto , Sanjay Srivatsan , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Tongqing Zhou
IPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , C12N7/00 , G01N33/564
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
-
公开(公告)号：US11136356B2
公开(公告)日：2021-10-05
申请号：US16756777
申请日：2018-10-16
发明人： Peter Kwong , John Mascola , Gwo-Yu Chuang , Hui Geng , Yongping Yang , Cheng Cheng , Jeffrey Boyington , Yen-Ting Lai
摘要： Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject.
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.034 秒)
