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公开(公告)号：US20220204911A1
公开(公告)日：2022-06-30
申请号：US17560870
申请日：2021-12-23
Applicant: The University of Kansas
Inventor： Bryce Stottlemire , Mei He , Cory Berkland
IPC: C12M1/42 , C12N5/0775 , C12M1/12 , C12M1/32
Abstract: Described herein is a system to remote-control magnetic actuation of dynamic cell culture. The systems described herein can include a porous, magnetic, elastomeric construct. The porous, magnetic, elastomeric construct can be formed from a composite including a biocompatible elastomer and a population of magnetic particles dispersed within the biocompatible elastomer.
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公开(公告)号：US10788486B2
公开(公告)日：2020-09-29
申请号：US15728155
申请日：2017-10-09
Inventor： Peng Zhang , Yong Zeng , Mei He
IPC: G01N33/543 , B01L3/00 , G01N33/68
Abstract: A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the substrate and polydopamine, and the polydopamine may be covalently coupled with the targeting receptor. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome. The substrate can be a particle (e.g., magnetic, such as magnetically responsive) or a surface in a microfluidic channel. The surface can be a top surface of a post, the post having a Y-shaped cross-sectional profile. In one aspect, the substrate is a particle. The capture device can include the target biological substance bound to the targeting receptor.
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公开(公告)号：US20180100853A1
公开(公告)日：2018-04-12
申请号：US15728155
申请日：2017-10-09
Inventor： Peng Zhang , Yong Zeng , Mei He
IPC: G01N33/543 , B01L3/00 , G01N33/68
CPC classification number: G01N33/54393 , B01L3/502707 , B01L3/502761 , B01L2200/0631 , B01L2200/0647 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , G01N33/54326 , G01N33/54353 , G01N33/6872
Abstract: A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the substrate and polydopamine, and the polydopamine may be covalently coupled with the targeting receptor. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome. The substrate can be a particle (e.g., magnetic, such as magnetically responsive) or a surface in a microfluidic channel. The surface can be a top surface of a post, the post having a Y-shaped cross-sectional profile. In one aspect, the substrate is a particle. The capture device can include the target biological substance bound to the targeting receptor.
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公开(公告)号：US20210268121A1
公开(公告)日：2021-09-02
申请号：US17236561
申请日：2021-04-21
Inventor： Mei He
IPC: A61K47/69 , G01N33/543 , G01N33/574
Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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公开(公告)号：US20210018501A1
公开(公告)日：2021-01-21
申请号：US17032037
申请日：2020-09-25
Inventor： Peng Zhang , Yong Zeng , Mei He
IPC: G01N33/543 , B01L3/00 , G01N33/68
Abstract: A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.
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Patent Agency Ranking
公开(公告)号：US11726086B2
公开(公告)日：2023-08-15
申请号：US17032037
申请日：2020-09-25
Inventor： Peng Zhang , Yong Zeng , Mei He
IPC: G01N33/543 , B01L3/00 , G01N33/68
CPC classification number: G01N33/54393 , B01L3/502707 , B01L3/502761 , G01N33/54326 , G01N33/54353 , G01N33/6872 , B01L2200/0631 , B01L2200/0647 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887
Abstract: A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.
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公开(公告)号：US11891668B2
公开(公告)日：2024-02-06
申请号：US17514724
申请日：2021-10-29
Inventor： Mei He
IPC: A61K47/00 , C12Q1/6886 , A61K47/69 , G01N33/574 , G01N33/543 , B03C1/015 , B03C1/30 , B01L3/00 , A61K49/00
CPC classification number: C12Q1/6886 , A61K47/6901 , A61K49/0097 , B01L3/502715 , B01L3/502761 , B03C1/015 , B03C1/30 , G01N33/5434 , G01N33/54333 , G01N33/574 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N2446/80
Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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公开(公告)号：US20230272120A1
公开(公告)日：2023-08-31
申请号：US17998177
申请日：2021-05-10
Applicant: The University of Kansas
Inventor： Mei He
Abstract: The present disclosure provides immunomagnetic compositions and their methods of use, in particular magnetic particles conjugated to peptides that bind and capture extracellular vesicles.
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公开(公告)号：US20220073999A1
公开(公告)日：2022-03-10
申请号：US17514724
申请日：2021-10-29
Inventor： Mei He
IPC: C12Q1/6886 , A61K47/69 , G01N33/574 , G01N33/543 , B03C1/015 , B03C1/30 , B01L3/00 , A61K49/00
Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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公开(公告)号：US11162143B2
公开(公告)日：2021-11-02
申请号：US17236561
申请日：2021-04-21
Inventor： Mei He
IPC: G01N27/00 , B03C5/00 , G01N27/12 , C12Q1/6886 , A61K47/69 , G01N33/574 , G01N33/543 , B03C1/015 , B03C1/30 , B01L3/00 , A61K49/00
Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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