公开(公告)号：US20220257666A1

公开(公告)日：2022-08-18

申请号：US17618241

申请日：2020-06-26

Applicant: The University of Tokyo

Inventor： Atsushi MIYAJIMA ,  Ami WATANABE

IPC: A61K35/39 ,  A61K35/545 ,  A61P3/10

Abstract: It is an object of the present invention to provide a method for preparing or separating pancreatic progenitor cells (or a group of pancreatic progenitor cells) that do not contain undifferentiated cells and efficiently differentiate into pancreatic islet cells. More specifically, the present invention relates to: pancreatic progenitor cells that appear in the process of differentiation of stem cells into pancreatic islet cells, which are characterized in that the pancreatic progenitor cells are positive to CD82; an agent for treating blood glucose level impairment, wherein the agent comprises the pancreatic progenitor cells; and a method for preparing pancreatic progenitor cells, wherein the method comprises separating CD82-positive cells.

公开(公告)号：US20180008749A1

公开(公告)日：2018-01-11

申请号：US15710507

申请日：2017-09-20

Applicant: The University of Tokyo

Inventor： Atsushi MIYAJIMA ,  Natsuko Inagaki ,  Fuyuki Inagaki ,  Norihiro Kokudo

IPC: A61L31/00 ,  A61L27/36 ,  A61K35/407 ,  A61L27/50 ,  A61L31/14

CPC classification number: A61L31/005 ,  A61K35/407 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/50 ,  A61L31/14 ,  A61L2430/28

Abstract: An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.

公开(公告)号：US20250109154A1

公开(公告)日：2025-04-03

申请号：US18833568

申请日：2023-01-27

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Tomohiko OHWADA ,  Yuko OTANI ,  Luying CHEN ,  Atsushi MIYAJIMA ,  Taketomo KIDO

IPC: C07F9/09 ,  A61K31/685 ,  A61P1/16

Abstract: The present invention relates to a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: wherein in Formula (I), definitions of R1, R2, L, m, and n are each shown in the specification.

公开(公告)号：US20160058917A1

公开(公告)日：2016-03-03

申请号：US14762189

申请日：2014-01-22

Applicant: The University of Tokyo

Inventor： Atsushi MIYAJIMA ,  Natsuko INAGAKI ,  Fuyuki INAGAKI ,  Norihiro KOKUDO

IPC: A61L31/00 ,  A61L27/36 ,  A61L27/50 ,  A61L31/14

CPC classification number: A61L31/005 ,  A61K35/407 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/50 ,  A61L31/14 ,  A61L2430/28

Abstract: An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.

Abstract translation: 本发明的目的是提供一种能够安全有效地防止粘附的防粘附材料。 本发明提供了由含有间皮细胞的细胞片组成的防粘连材料; 使用含有间皮细胞的细胞片的粘附防止方法和器官再生促进方法。

公开(公告)号：US20170198260A1

公开(公告)日：2017-07-13

申请号：US15313475

申请日：2015-05-25

Applicant: The University of Tokyo

Inventor： Atsushi MIYAJIMA ,  Natsuko INAGAKI ,  Fuyuki INAGAKI ,  Norihiro KOKUDO

IPC: C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0672 ,  C12N5/0062 ,  C12N2501/115 ,  C12N2501/999

Abstract: An object of the present invention is to provide a method for differentiating mesodermal cells into mesothelium cells. The present invention provides a method for producing mesothelial cells, including a first culturing step of culturing mesodermal cells in a medium containing basic fibroblast growth factor (bFGF) and oncostatin M.