公开(公告)号：US20040106858A1

公开(公告)日：2004-06-03

申请号：US10722246

申请日：2003-11-24

申请人： TheraSense, Inc.

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B005/00

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/14546 ,  A61B5/7445 ,  G06Q50/22 ,  H01L23/3107 ,  H01L23/49548 ,  H01L24/48 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2924/00014 ,  H01L2924/01012 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y02A90/22 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20030188427A1

公开(公告)日：2003-10-09

申请号：US10405765

申请日：2003-03-31

申请人： TheraSense, Inc.

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

IPC分类号： H05K003/02 ,  H05K003/10 ,  B23P017/00 ,  H05K003/20

CPC分类号： A61B5/14735 ,  A61B5/14532 ,  A61B5/14865 ,  A61B2562/0271 ,  A61B2562/125 ,  C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  G01N33/54393 ,  G01N33/66 ,  Y10T29/42 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49155 ,  Y10T29/49208 ,  Y10T29/49798 ,  Y10T156/1064 ,  Y10T156/1082

摘要： A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes the steps of providing a continuous substrate web, and disposing a pattern of a conductive material on the continuous substrate web to form one or more working electrodes and/or counter electrodes.

摘要翻译： 一种制造具有可重复表面的小型传感器的方法，包括电化学传感器。 一种方法包括在基材的表面中形成通道并在通道中设置导电材料以形成电极。 导电材料也可以通过其它冲击和非冲击方法形成在基板上。 在优选实施例中，该方法包括以下步骤：提供连续的衬底腹板，以及将导电材料的图案设置在连续的衬底腹板上以形成一个或多个工作电极和/或对电极。

公开(公告)号：US20030187338A1

公开(公告)日：2003-10-02

申请号：US10420057

申请日：2003-04-18

申请人： TheraSense, Inc.

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B005/05

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/00 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20030088166A1

公开(公告)日：2003-05-08

申请号：US10291969

申请日：2002-11-11

申请人： TheraSense, Inc.

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

IPC分类号： A61B005/05

CPC分类号： A61B5/14532 ,  A61B5/01 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/001 ,  C12Q1/006

摘要： An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.

摘要翻译： 使用衬底上的导电迹线形成的电化学分析物传感器可用于确定和/或监测体外或体内含分析物的流体中的分析物水平。 例如，可植入式传感器可用于在患者中连续或自动监测分析物（例如葡萄糖，乳酸盐或氧气）的水平。 电化学分析物传感器包括设置在基板上的基板和导电材料，导电材料形成工作电极。 在一些传感器中，导电材料设置在形成在传感器表面中的凹槽中。 可以提供电子转移剂和/或催化剂以促进分析物或其水平取决于分析物水平的第二化合物的电解。 在工作电极和参比电极或对置/参比电极之间形成电位，所得到的电流是体液中分析物的浓度的函数。