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公开(公告)号：US07705127B1
公开(公告)日：2010-04-27
申请号：US12249314
申请日：2008-10-10
申请人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , C07K2299/00
摘要： The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译： 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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公开(公告)号：US07888474B2
公开(公告)日：2011-02-15
申请号：US12723184
申请日：2010-03-12
申请人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , C07K2299/00
摘要： The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译： 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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3.发明授权Polynucleotides encoding soluble, stable forms of human double minute 2 polypeptides 失效编码可溶性，稳定形式的人类双分子2多肽的多核苷酸公开(公告)号：US08034907B2
公开(公告)日：2011-10-11
申请号：US12621241
申请日：2009-11-18
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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4.发明授权Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof 失效可溶性，稳定形式的HDM2，其结晶形式及其使用方法公开(公告)号：US07632920B2
公开(公告)日：2009-12-15
申请号：US10822254
申请日：2004-04-09
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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5.发明申请SOLUBLE, STABLE FORM OF HDM2, CRYSTALLINE FORMS THEREOF AND METHODS OF USE THEREOF 失效可溶性HDM2的稳定形式，其结晶形式及其使用方法公开(公告)号：US20100136620A1
公开(公告)日：2010-06-03
申请号：US12621241
申请日：2009-11-18
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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公开(公告)号：US20080199447A1
公开(公告)日：2008-08-21
申请号：US11961237
申请日：2007-12-20
申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
发明人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705 , C07K2299/00 , C07K2319/00
摘要： The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
摘要翻译： 本发明公开了包含活性ADAM33催化结构域的纯化多肽。 此外，本发明公开了编码本发明多肽的核酸。 本发明还公开了生长包含活性ADAM33催化结构域的多肽的X射线衍射晶体的方法。 此外，本发明公开了使用ADAM33的X射线衍射晶体在基于结构的药物设计中鉴定可调节ADAM33的酶活性的化合物的方法。 本发明还公开了通过施用治疗量的ADAM33催化结构域来治疗呼吸系统疾病的方法。
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公开(公告)号：US07335758B2
公开(公告)日：2008-02-26
申请号：US11541982
申请日：2006-10-02
申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
发明人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705 , C07K2299/00 , C07K2319/00
摘要： The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
摘要翻译： 本发明公开了包含活性ADAM33催化结构域的纯化多肽。 此外，本发明公开了编码本发明多肽的核酸。 本发明还公开了生长包含活性ADAM33催化结构域的多肽的X射线衍射晶体的方法。 此外，本发明公开了使用ADAM33的X射线衍射晶体在基于结构的药物设计中鉴定可调节ADAM33的酶活性的化合物的方法。 本发明还公开了通过施用治疗量的ADAM33催化结构域来治疗呼吸系统疾病的方法。
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公开(公告)号：US07208311B2
公开(公告)日：2007-04-24
申请号：US10741204
申请日：2003-12-19
申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
发明人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705 , C07K2299/00 , C07K2319/00
摘要： The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
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公开(公告)号：US07785879B1
公开(公告)日：2010-08-31
申请号：US11522698
申请日：2006-09-18
申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred W. Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred W. Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31
摘要： The present invention relates, inter alia, to PXR polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.
摘要翻译： 本发明尤其涉及PXR多肽和晶体，其可用于例如结晶和用于鉴定PXR调节剂的测定。
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10.发明授权公开(公告)号：US08048663B2
公开(公告)日：2011-11-01
申请号：US12815817
申请日：2010-06-15
申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31
摘要： The present invention relates to Pregnane X receptor (PXR) polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.
摘要翻译： 本发明涉及可用于例如结晶和用于鉴定PXR调节剂的测定中的孕烷X受体（PXR）多肽和晶体。
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