公开(公告)号：US20070060805A9

公开(公告)日：2007-03-15

申请号：US10917802

申请日：2004-08-12

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

摘要翻译： 光采样接口系统最小化并补偿由采样变化和测量位置状态波动引起的误差。 组件包括：具有孔的光学探针放置引导件，其中接收光学探针，在组织测量位置的表面上促进对表面组织具有最小的，可重复的干扰的可重复放置精度。 孔径产生组织弯月面，其最小化由于表面不规则性引起的干扰并控制采集的组织体积的变化; 放置在组织半月板上方的闭塞元件将半月板与环境波动隔离，稳定了现场的水化，从而表现出张力; 光学耦合介质消除皮肤表面和光学探针之间的气隙; 偏置校正元件对光谱测量和相关的分析物测量应用偏差校正。 当导向器被更换时，新的偏置校正被确定用于新放置的测量。 可以单独部署系统的单独组件。

公开(公告)号：US20050203359A1

公开(公告)日：2005-09-15

申请号：US11008001

申请日：2004-12-08

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti ,  Kevin Hazen ,  Donovan Berry ,  Roxanne Abul-Haj

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti ,  Kevin Hazen ,  Donovan Berry ,  Roxanne Abul-Haj

IPC分类号： A61B5/00 ,  G01N21/35

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6833

摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

摘要翻译： 公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。 本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导 控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。 可选组件包括闭塞元件和耦合流体。

公开(公告)号：US20050049466A1

公开(公告)日：2005-03-03

申请号：US10917802

申请日：2004-08-12

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

IPC分类号： A61B5/01 ,  A61B20060101 ,  A61B1/00 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/1455 ,  A61K9/00 ,  G01N21/01 ,  G01N21/35

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

摘要翻译： 光采样接口系统最小化并补偿由采样变化和测量位置状态波动引起的误差。 组件包括：具有孔的光学探针放置引导件，其中接收光学探针，在组织测量位置的表面上促进对表面组织具有最小的，可重复的干扰的可重复放置精度。 孔径产生组织弯月面，其最小化由于表面不规则性引起的干扰并控制采集的组织体积的变化; 放置在组织半月板上方的闭塞元件将半月板与环境波动隔离，稳定了现场的水化，从而表现出张力; 光学耦合介质消除皮肤表面和光学探针之间的气隙; 偏置校正元件对光谱测量和相关的分析物测量应用偏差校正。 当导向器被更换时，新的偏置校正被确定用于新放置的测量。 可以单独部署系统的单独组件。

公开(公告)号：US20080200783A9

公开(公告)日：2008-08-21

申请号：US10384049

申请日：2003-03-07

申请人： Thomas Blank ,  Timothy Ruchti ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz

发明人： Thomas Blank ,  Timothy Ruchti ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1491 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/31 ,  G01N21/33 ,  G01N21/359 ,  G01N21/65 ,  G01N2021/3595

摘要： A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.

摘要翻译： 用于非侵入性葡萄糖测量的方法和装置从组织的自然反应间接测量葡萄糖对分析物浓度的变化。 间接测量方法利用受葡萄糖浓度影响或与葡萄糖浓度相关的因素，如折射率，电解质分布或组织散射。 通过稳定测量部位的组织的光学特性，可以大大提高测量可靠性，从而调节样品位置的血液灌注速率。 通过光谱测量直接影响灌注的控制参数（如皮肤温度）来监测和稳定灌注。 控制参数保持在设定点的范围内，从而稳定灌注。 使用各种手段控制皮肤温度，包括使用主动加热和冷却元件，无源器件，例如热封，以及通过使用具有良好传热特性的加热耦合介质。

公开(公告)号：US20050267342A1

公开(公告)日：2005-12-01

申请号：US11117104

申请日：2005-04-27

申请人： Thomas Blank ,  George Acosta ,  Timothy Ruchti ,  Mutua Mattu ,  Alexander Lorenz ,  Kevin Hazen ,  James Henderson

发明人： Thomas Blank ,  George Acosta ,  Timothy Ruchti ,  Mutua Mattu ,  Alexander Lorenz ,  Kevin Hazen ,  James Henderson

IPC分类号： A61B5/00 ,  G01N21/35

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/4869 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2562/0242 ,  G01N21/359

摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.

摘要翻译： 提供了一种用于无创采样的方法和装置。 更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。 使用动态探针接口来收集目标样品的光谱，根据x-，y-和z-轴中的至少一个来控​​制样品探针相对于组织样品的定位和/或样品的控制 组织位移以最小化由采样过程导致的频谱变化，并增加分析物质的估计精度和精度。

公开(公告)号：US20070179367A1

公开(公告)日：2007-08-02

申请号：US11564741

申请日：2006-11-29

申请人： Timothy Ruchti ,  Thomas Blank ,  Alexander Lorenz

发明人： Timothy Ruchti ,  Thomas Blank ,  Alexander Lorenz

IPC分类号： A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7267 ,  G16H50/20

摘要： A method and apparatus for calibration development using clustering is disclosed. More particularly, the invention relates to subsequent calibration development using clusters that are individually interference compensated and to subsequent estimation. Estimation of analyte property values from data, such as noninvasive spectra, is improved by a calibration method that uses clusters that are individually interference-compensated.

摘要翻译： 公开了一种使用聚类进行校准开发的方法和装置。 更具体地说，本发明涉及使用单独干扰补偿的群集和随后的估计的随后的校准开发。 通过使用单独进行干扰补偿的簇的校准方法来改进来自诸如非侵入光谱的数据的分析物质性值的估计。

公开(公告)号：US20050240090A1

公开(公告)日：2005-10-27

申请号：US11095331

申请日：2005-03-30

申请人： Timothy Ruchti ,  Thomas Blank ,  Alexander Lorenz

发明人： Timothy Ruchti ,  Thomas Blank ,  Alexander Lorenz

IPC分类号： A61B5/00

CPC分类号： A61B5/14532

摘要： This invention provides a method and apparatus that corrects for tissue related interference calibration and/or measurement of biological parameters noninvasively. The invention concerns such terms as outlier identification, filtering, spectral correction, and baseline subtraction steps that, when used together, provides for noninvasive measurement of biological parameters, such as glucose concentration.

摘要翻译： 本发明提供一种非侵入性校正组织相关干扰校准和/或生物参数测量的方法和装置。 本发明涉及诸如异常值识别，过滤，光谱校正和基线减法步骤之类的术语，当它们一起使用时，提供诸如葡萄糖浓度的生物学参数的非侵入性测量。

公开(公告)号：US20060017923A1

公开(公告)日：2006-01-26

申请号：US11188064

申请日：2005-07-22

申请人： Timothy Ruchti ,  Alexander Lorenz ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alexander Lorenz ,  Kevin Hazen

IPC分类号： G01J3/28

CPC分类号： G01N21/274 ,  G01J3/28 ,  G01J3/433 ,  G01N21/359 ,  G01N2201/129 ,  G01N2201/1293

摘要： The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.

摘要翻译： 本发明包括用于增强非侵入光谱分析的方法和装置，从而提高分析性能。 更具体地，本发明包括用分析物过滤器处理非侵入光谱的方法和装置，其优选地拒绝可能对测量系统有害的变化，同时传递概率地对目标分析物是唯一的信号。 随后，分析物过滤的数据用于在存在噪声，干扰，状态变化和/或跨分析仪的情况下估计分析物质（例如葡萄糖浓度）。

公开(公告)号：US20050149300A1

公开(公告)日：2005-07-07

申请号：US10976530

申请日：2004-10-29

申请人： Timothy Ruchti ,  Alexander Lorenz ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alexander Lorenz ,  Kevin Hazen

IPC分类号： A61B5/00 ,  G01N21/35 ,  G06F17/10

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/359

摘要： The invention provides for transformation of a section of a data block independently of the transformation of separate or overlapping data blocks to determine a property related to the original matrix, where each of the separate or overlapping data blocks are derived from an original data matrix. The transformation enhances parameters of a first data block over a given region of an axis of the data matrix, such as signal-to-noise, without affecting analysis of a second data block derived from the data matrix. This allows for enhancement of analysis of an analyte property, such as concentration, represented within the original data matrix. In a first embodiment of the invention, a separate decomposition and factor selection for each selected data matrix is performed with subsequent score matrix concatenization. The combined score matrix is used to generate a model that is subsequently used to estimate a property, such as concentration represented in the original data matrix. In a second embodiment, each data matrix is independently preprocessed. Demonstration of the invention is performed through glucose concentration estimation from noninvasive spectra of the body.

摘要翻译： 本发明提供了数据块的一部分的变换，独立于单独或重叠的数据块的变换，以确定与原始矩阵相关的属性，其中分离的或重叠的数据块中的每一个从原始数据矩阵导出。 该变换增强了数据矩阵的轴的给定区域（例如信号到噪声）上的第一数据块的参数，而不影响从数据矩阵导出的第二数据块的分析。 这允许增强在原始数据矩阵内表示的分析物质（例如浓度）的分析。 在本发明的第一实施例中，对于每个选择的数据矩阵进行单独的分解和因子选择，随后的得分矩阵连接。 组合得分矩阵用于生成随后用于估计属性的模型，例如在原始数据矩阵中表示的浓度。 在第二实施例中，每个数据矩阵是独立预处理的。 本发明的演示通过来自身体的非侵入性光谱的葡萄糖浓度估计来进行。

公开(公告)号：US20050119541A1

公开(公告)日：2005-06-02

申请号：US10978116

申请日：2004-10-29

申请人： Alexander Lorenz ,  Timothy Ruchti

发明人： Alexander Lorenz ,  Timothy Ruchti

IPC分类号： A61B5/00 ,  A61B13/00 ,  G01N21/27 ,  G01N21/35

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2560/0233 ,  G01N21/278 ,  G01N21/359

摘要： The invention relates to a noninvasive analyzer and a method of using information determined at least in part from in-vitro spectra of tissue phantoms or analyte solutions to aid in the development of a noninvasive glucose concentration analyzer and/or in the analysis of noninvasive spectra resulting in glucose concentration estimations in the body. The preferred apparatus is a spectrometer that includes a base module and a sample module that is semi-continuously in contact with a human subject and that collects spectral measurements which are used to determine a biological parameter in the sampled tissue, such as glucose concentration. Collection of in-vitro samples is, optionally, performed on a separate instrument from the production model allowing the measurement technology to be developed on a research grade instrument and used or transferred to a target product platform or production analyzer for noninvasive glucose concentration estimation.

摘要翻译： 本发明涉及非侵入性分析仪和使用至少部分地从组织模型或分析物溶液的体外光谱确定的信息的方法，以帮助非侵入性葡萄糖浓度分析仪的开发和/或在非侵入性光谱的分析中产生 在体内的葡萄糖浓度估计。 优选的装置是一种光谱仪，其包括基本模块和与人类受试者半连续接触的样本模块，并收集用于确定采样组织中的生物学参数（如葡萄糖浓度）的光谱测量。 体外样品的收集可选地在与生产模型分离的仪器上进行，允许在研究级仪器上开发测量技术，并将其用于或转移到用于非侵入性葡萄糖浓度估计的目标产物平台或生产分析仪。